Daily, high dose vitamin D supplementation reduces the incidence of myocardial infarctions in surgical intensive care unit patients
Clinical and Experimental Cardiology Conf Texas Nov 30, 2015
L. Ray Matthews, Morehouse School of Medicine, USA
| ICU | 50,000 IU | infarction rate | patients with infarction | Cost of ICU if have infarction |
| Group 1 | weekly | 7.8% | 22 | $149,000 |
| Group 2 | daily | 3.9% | 11 | $32,000 |
Note: some surgeons now refuse elective surgery for patients with low vitamin D
Surgical outcome is far better if pateints have good levels of vitamin D
Note: a loading dose will provide a good level in about 1 week
See also VitaminDWiki
- Surgical outcomes are better for higher levels of Vitamin D – systematic review May 2015
- Critically ill need vitamin D – how much and which test to use is TBD – Nov 2014
- ICU death 2X more likely if low vitamin D (sensitivity and selectivity chart) – May 2015
- Shorter time in ICU if have higher level of vitamin D – April 2012
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 Matthews, et al
- Vitamin D advocate (Dr. Matthews) is now in Who’s Who Marquis – Feb 2018
- 2X more complications after heart surgery associated with high level of vitamin D – Jan 2013
- Half as many heart deaths for those with high levels of vitamin D – meta-analysis Sept 2012
- Major Heart attacks occur 40 percent more often if vitamin D lower than 7 ng – Feb 2013
Perhaos the need for heart attack surgery could have been eliminated by having high level of vitamin D - Trauma and surgery category listing has
274 items along with related searches In both Intervention AND Trauma/surgery categories
- 500,000 IU of vitamin D increased Hemoglobin in Mechanically Ventilated adults – RCT Jan 2018
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Surgeries far less likely to cause heart attack and lower cost with daily 50,000 IU of vitamin D – Oct 2018
- Knee replacement not helped by 2,000 IU of vitamin D (both too late and too little) – RCT July 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Ventilator-associated pneumonia death rate cut in half by Vitamin D injection (300,000 IU) – RCT July 2017
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – March 2017
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- 18 fewer hospital days if given 500,000 IU of vitamin D while ventilated in ICU – RCT June 2016
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- Heart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Vitamin D reduces sepsis
Cardiovascular category listing has
425 items In Cardiovascular category - Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Abstract
Often overlooked, are the roles that chronic inflammation/oxidative stress play in the pathogenesis of myocardial infarctions. We hypothesized that vitamin D (a secosteroid hormone with anti-inflammatory capabilities) would reduce the incidence, length of stay, and hospital costs in surgical intensive care unit patients. We performed a prospective study of 565 patients divided into two groups admitted to the surgical intensive care unit at Grady Memorial Hospital between August 2009 and August 2012. Group 1 was treated with vitamin D 50,000 international units weekly. Group 2 was treated with vitamin D 50,000 international units daily.Primary outcomes were incidence of myocardial infarctions, length of stay, and cost. There were not any statistical differences between the two groups in terms of demographics: age, gender, race, serum albumin, CD4 count, or baseline vitamin D levels.
The number/incidence of myocardial infarctions in Group 1 was 22 (7.8%) and 11 (3.9%) in Group 2 (p value 0.047).
The length of stay for the 22 patients in Group 1 who had a myocardial infarctions was 36.1 days and 8.2 days for the 11 patients in Group 2 (p value 0.007).
The intensive care unit cost for the 22 patients in Group 1 who had a myocardial infarction was $138,991 and $31,549 for the 11 patients in Group 2 (p 0.0005).
Our study demonstrates that vitamin D deficiency is associated with an increased incidence of myocardial infarctions, cost, and length of stay. Further studies are needed to fully assess the impact of vitamin D on cardiovascular health.Biography
Matthews is a full-time faculty member of Morehouse School of Medicine, Department of Surgery in Atlanta, Georgia, where he serves as Associate Professor of Clinical Surgery. Matthews serves as Director of Surgical Critical Care. He received his medical degree from the University of Mississippi and completed his surgical residency training at Morehouse School of Medicine. He completed a two year surgical critical care fellowship at the Mayo Clinical College of Medicine in Rochester, Minnesota. He is a published author on landmark vitamin D-deficiency manuscripts.Download the PDF from VitaminDWiki
Cost savings computation by VitaminDWiki
$0.20 per capsule X 10 days X 11 people = $22
ICU costs per 11 people
$69,500 Weekly dosing
$32,000 Daily dosing
Cost savings $37,500 for $22 of Vitamin DHeart Attack ICU costs reduced $37,000 by $20 of Vitamin D – Nov 2015Printer Friendly PDF this page! Follow this page for updates4548 visitors, last modified 11 May, 2018, This page is in the following categories (# of items in each category)