Does vitamin D play a significant role in type 2 diabetes?
BMC Endocr Disord. 2015 Feb 26;15(1):5. doi: 10.1186/s12902-015-0003-8.
Sheth JJ1, Shah A2, Sheth FJ3, Trivedi S4, Lele M5, Shah N6, Thakor P7, Vaidya R8.
94% of the participants has < 20 ng of vitamin D
Glycation control inverse relationship in the other 6% (> 20 ng)
See also VitaminDWiki
Overview Diabetes and vitamin D
Why India's vitamin D deficiency is grim - 40 pages Feb 2014
80 percent of young adults had low vitamin D tests in Mumbai India - 2011
Diabetes leads to many diseases - need to restore the vitamin D levels
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Diabetes ==> Alzheimer's
Diabetes <==> Depression
Pages listed in BOTH the categories Diabetes and Dark Skin
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Blacks die more often than whites of many diseases (they have less vitamin D) – 2012
- Diabetic blacks – 80 percent had low vitamin D (less than 20 ng) a decade before – Sept 2017
- Diabetes is associated with low vitamin D in various races, but not blacks – Sept 2015
- Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- Diabetic glycation control is inversely related to Vitamin D in India – Feb 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Dr. Holick video on vitamin D - March 2013
- African-Americans at high risk of obesity and diabetes - 2011
- Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012
- Hyperglycemia in black veterans is associated with low vitamin D – Nov 2012
- Diabetics with darker skin were more vitamin D deficient – May 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- 97 percent of Native American children have less than 30 ng of vitamin D – Oct 2011
- Diabetic neuropathy and low vitamin D, especially in blacks - July 2011
- Studies linked low vitamin D and dark skin to Obesity, Diabetes, and heart – June 2011
- Not yet certain that vitamin D reduces cardiovascular and diabetes in blacks – Mar 2011
- Diabetes Statistics including more diabetes with darker skin – 2007
- Insulin resistance correlated with low vitamin D levels in Arab Americans – June 2010
- Insulin sensitivity associated with Vit D in A-A April 2010
- Vitamin D deficiency and insulin insensitivity in African Americans - 2010
Download the PDF from VitaminDWiki
Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.
Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.
Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).
Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.
B. Relationship between vitamin D non-deficient T2DM cases and HbA1c.
D. Relationship between vitamin D non-deficient Controls and HbA1c.
Clipped from PDF
. . . “low serum vitamin D levels in 70% to 100% populations across India.”
“This is likely to be due to
- increased skin pigmentation,
- low exposure to direct sunlight,
- obesity and malabsorption”