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Diabetic glycation control is inversely related to Vitamin D in India – Feb 2015

Does vitamin D play a significant role in type 2 diabetes?

BMC Endocr Disord. 2015 Feb 26;15(1):5. doi: 10.1186/s12902-015-0003-8.
Sheth JJ1, Shah A2, Sheth FJ3, Trivedi S4, Lele M5, Shah N6, Thakor P7, Vaidya R8.

VitaminDWiki Summary

94% of the participants has < 20 ng of vitamin D
Glycation control inverse relationship in the other 6% (> 20 ng)
See also VitaminDWiki
Overview Diabetes and vitamin D
Why India's vitamin D deficiency is grim - 40 pages Feb 2014
80 percent of young adults had low vitamin D tests in Mumbai India - 2011

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Pages listed in BOTH the categories Diabetes and Dark Skin

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BACKGROUND:
Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.

METHODS:
Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.

RESULTS:
Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).

CONCLUSION:
Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.

PMID: 25887335

Glycation control

Image
B. Relationship between vitamin D non-deficient T2DM cases and HbA1c.
D. Relationship between vitamin D non-deficient Controls and HbA1c.

Clipped from PDF

. . . “low serum vitamin D levels in 70% to 100% populations across India.”
“This is likely to be due to

  • increased skin pigmentation,
  • low exposure to direct sunlight,
  • obesity and malabsorption”

Attached files

ID Name Comment Uploaded Size Downloads
5371 Diabetes India.pdf admin 22 Apr, 2015 1.16 Mb 1286
5370 Diabetics India.jpg admin 22 Apr, 2015 36.58 Kb 4501