Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial
Brain and Behaviour https://doi.org/10.1002/brb3.2342
Masoumeh Rajabi-Naeeni,Mahrokh Dolatian,Mostafa Qorbani,Amir Abbas Vaezi,
Summary article by GrassrootsHealth
2 + 2 = 4
Expect to find that vitamin D is al least synergistic with Omega-3 for many health problems
Omega-3 and Vitamin D each treat many mental health problems - April 2018
Anticipate finding other synergistic combinations, such as:
Vitamin D + (Resveratrol or Curcumin or Querctin or Zinc)
Vitamin D + Magnesium
Vitamin D + Iron
Vitamin D + Vitamin K2
Depression in VitaminDWiki
Intervention of Vitamin D for Depression
- Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022
- Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case) – July 2021
- Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT Feb 2020
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D - no cure for depression (when you use only 1200 IU) – Aug 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation – Feb 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013
- Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
Meta-analyses of Vitamin D and Depression
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Depression reduced if use more than 2,800 IU of vitamin D – meta-analysis Aug 2022
- Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses July 2022
- Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Depression is associated with low Magnesium – meta-analysis April 2015
- Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
- Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis – Nov 2014
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- Low vitamin D and depression - Study and meta-analysis, April 2013
- 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis Jan 2013
Depression category listing has 245 items along with related searches
Intervention of Omega-3 for Depression
-
Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
-
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022
-
Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
-
Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021
-
Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
-
Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019
-
Omega-3 helps treat Major Depression – International Consensus Sept 2019
-
Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
-
Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018
-
Depression treated by Omega-3 (again) – meta-analysis Aug 2019
-
Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
-
Occupational burnout reduced after 8 weeks of Omega-3 – RCT July 2019
-
Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
-
Psychotic disorders not treated by Omega-3 when patents take anti-depressants and get therapy – June 2018
-
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
-
Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019
-
Benefits of Omega-3 beyond heart health - LEF Feb 2018
-
Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
-
Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
-
Omega-3 reduces many psychiatric disorders – 2 reviews 2016
-
Omega-3 does not consistently treat depression if use small amounts for short time period – review Oct 2016
-
How Omega-3 Fights Depression – LEF July 2016
-
Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
-
Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015
-
Depression substantially decreased with Omega-3 – Sept 2015
-
Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015
-
Omega-3 prevents PTSD and some mood disorders - Aug 2015
-
Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
-
Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
Sleep category in VitaminDwiki starts with
91 items in sleep category
A few items in SLEEP category
- Sleep problems cured by vitamin D, etc. – workshops and patient workbooks – Gominak 2018
- Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Iron deficiency is a cause of Vitamin D deficiency Depression
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
Sleep and Omega-3:
-
Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
-
Sleep problems associated with Omega problems - April 2021
-
Omega-3 greatly reduced sleep deprivation problems in rats – June 2018
-
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
-
Obstructive Sleep Apnea reduced by Omega-3 – June 2016
-
Longer time to fall to sleep in winter unless eat salmon (vitamin D and Omega-3) – May 2014
-
Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
ANXIETY in title
This list is automatically updated
Items found: 10
Vitamin D and Omega-3 category starts with
377 Omega-3 items in category
Omega-3 helps with: Autism (9 studies), Depression (29 studies), Cardiovascular (32 studies), Cognition (48 studies), Pregnancy (39 studies), Infant (26 studies), Obesity (13 studies), Mortality (5 studies), Breast Cancer (6 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details
Download the PDF from VitaminDWiki
Purpose
Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.
Methods
The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.
Results
A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).
Conclusion
Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.
Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
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Intervention of Omega-3 for Depression
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021
- Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
- Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019
- Omega-3 helps treat Major Depression – International Consensus Sept 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018
- Depression treated by Omega-3 (again) – meta-analysis Aug 2019
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Occupational burnout reduced after 8 weeks of Omega-3 – RCT July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Psychotic disorders not treated by Omega-3 when patents take anti-depressants and get therapy – June 2018
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Omega-3 does not consistently treat depression if use small amounts for short time period – review Oct 2016
- How Omega-3 Fights Depression – LEF July 2016
- Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
- Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015
- Depression substantially decreased with Omega-3 – Sept 2015
- Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015
- Omega-3 prevents PTSD and some mood disorders - Aug 2015
- Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
- Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
Sleep category in VitaminDwiki starts with
A few items in SLEEP category
- Sleep problems cured by vitamin D, etc. – workshops and patient workbooks – Gominak 2018
- Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Iron deficiency is a cause of Vitamin D deficiency Depression
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
Sleep and Omega-3:
- Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
- Sleep problems associated with Omega problems - April 2021
- Omega-3 greatly reduced sleep deprivation problems in rats – June 2018
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Obstructive Sleep Apnea reduced by Omega-3 – June 2016
- Longer time to fall to sleep in winter unless eat salmon (vitamin D and Omega-3) – May 2014
- Serotonin regulated by Vitamin D – part 1 autism – Feb 2014
ANXIETY in title
This list is automatically updated
Vitamin D and Omega-3 category starts with
CIlck here for details
Download the PDF from VitaminDWiki
Purpose
Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.
Methods
The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.
Results
A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).
Conclusion
Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.
Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
| 1621 visitors, last modified 27 Sep, 2021, |
| ID | Name | Comment | Uploaded | Size | Downloads | |
|---|---|---|---|---|---|---|
| 16293 | O3 D adi d additive.jpg | admin 27 Sep, 2021 10:39 | 116.21 Kb | 284 | ||
| 16292 | Omeg-3 and Vitamin D additive.pdf | PDF 2021 | admin 27 Sep, 2021 10:39 | 286.21 Kb | 117 |