Need at least 80 ng of vitamin D if have chronic kidney disease – May 2012

CKD Patients May Need Higher 25D Levels

Jody A. Charnow May 11, 2012

NATIONAL HARBOR, Md.—Levels of 25-hydroxyvitamin D (25D) higher than 20 ng/mL would be required to normalize intact parathyroid hormone (iPTH) in patients with stages 3 and 4 chronic kidney disease (CKD) with vitamin D insufficiency and secondary hyperparathyroidism, researchers concluded in a study presented at the National Kidney Foundation 2012 Spring Clinical Meetings.

Researchers noted that the Institute of Medicine recently suggested 20 ng/mL as the lower limit of the normal range for 25D, but this limit may be significantly higher among individuals with reduced kidney function.

The investigators examined the relationship between iPTH and 25D in patients with stages 3 and 4 CKD in a doubled-blind study of CTAP101 Capsules, a modified-release formulation of calcifediol. Seventy-eight patients aged 18-80 years were randomized to receive the capsules or matching placebo for six weeks. At baseline, subjects had a mean eGFR of 39.4 mL/min/1.73 m2, iPTH of 136 pg/mL, 25D level of 22.4 ng/mL, serum calcium level, 9.3 mg/dL, and serum phosphorus level of 3.7 mg/dL.

In the active drug group, a 25D level of 84 ng/mL was associated with the upper limit of normal for iPTH (72 pg/mL). Some patients had 25D increases exceeding 100 ng/mL, but investigators reported observing no significant change in calcium or phosphorus.

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See also VitaminDWiki

• Overview Kidney and vitamin D
• All items in category Kidney and Vitamin D 229 items
• Chronic Kidney Disease needs Vitamin D: how much, what kind - many studies
• More than 30 ng of vitamin D is sometimes needed (Kidney needs 50 ng) – March 2019

Optimum category starts with
The RDA is barely enough for the bones to survive.
   Need an optimal level for the body to thrive

99 items in Optimum Vitamin D category

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• More than 30 ng of vitamin D is needed for many diseases - Feb 2022 has

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• Vitamin D sufficiency 10 to 30 ng, optimal 40 to 80 ng (no consensus)– May 2018
• Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012
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See also web

• Cardiovascular effects of cholecalciferol treatment in dialysis patients - RCT April 2014
  3000 IU for 6 months ==> 32 ng did NOT help; free full text online