A Longitudinal Study for the Effect of Vitamin D Adjunct to Chemotherapy on Non-Metastatic Breast Cancer Patients after Mastectomy
Breast Cancer Reports DOI : http://dx.doi.org/10.7243/2057-1631-6-1
Trial injected 200,000 IU of vitamin D monthly for 4 months to half of the participants
Chemo typically increases BMD decline by 2X to 3X
- Injection category listing has
63 items along with related searches - Loading doses are similar to injection is if far less expensive
- Loading dose for Vitamin D category listing has
206 items along with related searches - Cancer - Breast category listing has
256 items along with related searches - Cancer - after diagnosis category listing has
113 items along with related searches - Metastatic Cancer probably reduced by vitamin D - many studies
- Bone fractures 2.8 X more likely among cancer survivors (perhaps low vitamin D) – Dec 2017
- Overview Fractures and vitamin D
- Cancers and Cancer therapyboth reduce levels of Vitamin D
- Reduced Vitamin D levels increase risk of bone fracture
- Cancer - after diagnosis pages containing CHEMO in title (31 as of Oct 2021)
 Download the PDF from VitaminDWiki
Note: Those getting Vitamin D
1) Lost weight
2) Reduce BMI
3) Reduced lumors (Vitamin D is known to improve Chemo)
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BMD INCREASED in those getting Vitamin D instead of decreasingEhab I. Mohamed1*, Azza M. Helal2,3, Noha M. Awad4, Gihane I. Khalil5, Amani M. Bayoumi6 and Nadia A. Abd El Moneim7
*Correspondence: Ehab I. Mohamed eimohamed at yahoo.com; ehab.abdo at alexu.edu.eg
1. Medical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.Background: Women with BC are at increased risk for the development of osteoporosis and skeletal fractures. We investigated the effect of CAF chemotherapy alone and adjunct to vitamin D treatment on biochemical markers of bone formation and on segmental and total bone mineral density (BMD) for non-metastatic breast cancer (NMBC) postmenopausal women who had gone through a mastectomy.
Methods: The study population was comprised of 200 NMBC women who were divided into two equal groups; before and after treatment with CAF chemotherapy alone and before and after treatment with CAF+Vitamin D treatment protocols. Other 100 healthy participants served as the Control group. All participant women were subjected to blood biochemical analysis and segmental and total BMD measurements using Dual-energy X-ray Absorptiometry technique.
Results: We found that CAF chemotherapy alone had no effect on women’s body weight, BMI, tumor marker CA15-3, PTH, ALP and Ca levels as compared to the initial state, while CAF+Vitamin D adjunct treatment caused significant reductions in their levels as compared to the initial state and Healthy Controls. We found also that CAF chemotherapy alone had no effect on plasma levels of P and Vitamin D as compared to initial state yet, CAF+Vitamin D adjunct treatment caused significant elevations in their levels as compared to the initial state and Healthy Controls.
Conclusions: Vitamin D may decrease the risk of BC recurrence by decreasing risk factors like body weight and serum levels of CA15-3, PTH, ALP, and Ca, thus increasing segmental and total BMD and decreasing the risk of osteoporosis.
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 20195458 visitors, last modified 04 Oct, 2021, This page is in the following categories (# of items in each category)Attached files
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