Loading...
 

Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021

The association between vitamin D and acute rejection in human kidney transplantation: A systematic review and meta-analysis study

Transpl Immunol . 2021 May 18;101410. doi: 10.1016/j.trim.2021.101410
Mohammad Mirzakhani 1, Sheyda Mohammadkhani 2, Shirin Hekmatirad 3, Soudabeh Aghapour 4, Negar Gorjizadeh 5, Mehdi Shahbazi 6, Mousa Mohammadnia-Afrouzi 7

VitaminDWiki

Kidney transplant worked better if initially have high level of vitamin D – April 2012

Kidney category starts with


Overview Kidney and vitamin D contains the following summary

 Download the PDF from VitaminDWiki

Background: Vitamin D (VitD) deficiency is associated with several diseases such as multiple sclerosis, rheumatoid arthritis, respiratory infection, and so forth. In the field of transplantation (kidney transplantation), some studies reported that patients with VitD deficiency are of increased chance of acute rejection, but other studies did not show such a chance. On the other hand, since VitD is a modulatory factor and can reduce the inflammatory response, understanding the exact role of it in transplantation may contribute to tolerance condition in these patients.

Methods: The electronic databases, including PubMed, Scopus, Embase, ProQuest, Web of Science, and Google Scholar, were searched for eligible studies. In general, 14 studies with a total of 4770 patients were included in this meta-analysis. Regarding the methodological heterogeneity, we selected a random-effects combination model. Moreover, OR was chosen as an effect size for this study.

Results: After the combination of 14 studies, we showed that patients in the VitD-deficient group had an 82% increased chance of acute rejection compared with patients in the VitD-sufficient group, and this effect was significant (OR 1.82; 95% confidence interval [CI] [1.29, 2.56]; I2 = 52.3%). This result was significant, and, regarding the narrow CI, it can be a conclusive result. Study quality and gender variables were the main sources of inconsistent results in the primary studies. Moreover, using meta-regression, we showed that VitD deficiency (independent from the estimated glomerular filtration rate (eGFR) of patients) increased the chance of acute rejection.

Conclusion: The normal VitD status of patients a few days before and after transplantation can reduce the chance of acute rejection.


Vitamin D page titles containing the word "transplant"


Created by admin. Last Modification: Saturday May 22, 2021 12:11:24 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
15621 Kidney transplant meta-analysis.pdf admin 22 May, 2021 333.06 Kb 455