History and future
- Animal studies: apply vitamin D to the implant
- Human: Observe that high Vitamin D level is associated with implant success
- Human takes Vitamin D before the procedure
Start supplementing 3 months before the procedure or a loading dose of 400,000 IU a week before - Human: Apply Vitamin D to the implant
Note: A few drops of topical Vitamin D to nearby gums 2X daily for weeks
should result in less pain, improved implant - Human future implant exploration:
Take supplements known to improve bone growth (outside of the mouth)
Vitamin D, Boron, Magnesium, Silicon, plant-based Calcium, Vitamin K2, etc. 1 2
- 5+ VitaminDWiki Dental pages have IMPLANT in the title
- Vitamin D Supplementation for Prevention of Dental Implant Failure: A Systematic Review - Jan 2022
- Less bone loss after implant if have more Vitamin D in blood - June 2022
- See also: Bone implants aided by Vitamin D in 80 percent of studies, conclusion – more studies needed – Feb 2016
5+ VitaminDWiki Dental pages have IMPLANT in the title
The list is automatically updated
Vitamin D Supplementation for Prevention of Dental Implant Failure: A Systematic Review - Jan 2022
International Journal of DentistryVolume 2022, Issue 1 https://doi.org/10.1155/2022/2845902
Alaa Makke
Background. Many factors play a significant role in osseointegration and healing after dental implant insertion and restoration. Some factors are related to dental biomaterials, such as the dental implant, prosthesis, and grafting materials. Other factors can be connected to operator skills and accumulated experience. Local and systemic patient-related factors are crucial in determining the success of the dental implant. Thorough examination and analysis of local factors using available examination tools are vital to prepare the implant candidate for such treatment. The patient’s systemic condition directly affects the healing of the dental implant. One of the most overlooked systemic factors is the patients’ vitamin D level, which influences bone formation around the implant and subsequent osseointegration. The current review examined the available literature regarding the association between vitamin D supplementation and dental implant osseointegration.
Methods. Data of this review were derived from recent research available on PubMed, Google Scholar, and Scopus. Inclusion criteria were the relation between the vitamin D serum and dental implant osseointegration or failure. The Systematic Reviews and Meta-Analyses (PRISMA) checklist was followed to perform the review. The study’s outcome was the need for vitamin D supplementation to prevent implant failure.
Results. Five human studies (including case reports, case series, and retrospective studies) and six animal studies. All included studies discussed the relationship between vitamin D, early dental implant failure, and bone implant contact.
- Three retrospective studies found no significant relationship between vitamin D supplementation and EDIFs in humans.
- On the other hand, one retrospective study showed a significant relationship in humans.
- A case report and case series claimed that the implant was successfully placed after vitamin D supplementation.
- A total of four animal studies showed a significant relationship between vitamin D supplementation and osseointegration of the dental implant.
- Two animal studies showed no significant association.
Conclusion. To ensure optimal treatment outcomes, it is recommended to supplement the patient with vitamin D if the serum level is not within the normal range. Further clinical studies and case reports are needed to confirm the association between serum vitamin D levels and osseointegration.
Download the PDF from VitaminDWiki
Less bone loss after implant if have more Vitamin D in blood - June 2022
Does the serum level of vitamin D affect marginal bone loss around dental implants?
International J. of Oral and Maxillofacial Surgery Vol. 51, Issue 6, June 2022, Pages 832-836 partial PDF is online
Vitamin D is effective in bone healing. The aim of this study was to assess marginal bone loss (MBL) around dental implants in patients with sufficient and insufficient serum levels of vitamin D. This was a prospective cohort study with a pre-protocol population. Patients who underwent dental implantation in the first or second molar region and had a long-cone peri-apical digital radiograph taken at the time of loading and 12 months later were studied. Patients were assigned to one of three groups based on their serum vitamin D level: group 1, the serum level of vitamin D was deficient, group 2 insufficient, and group 3 sufficient. The marginal bone level change from immediately after loading to 12 months later was considered as MBL. Analysis of variance (ANOVA) was applied to compare MBL between the three groups. Ninety patients were included (30 in each group).
The mean MBL was
- 1.38 ± 0.33 mm in group 1, (deficient)
- 0.89 ± 0.16 mm in group 2, (insufficient)
- 0.78 ± 0.12 mm in group 3. (sufficient)
Analysis of the data demonstrated a significant difference in the mean MBL among the three groups (P < 0.001). There was a correlation between MBL and vitamin D serum levels (P < 0.001). It appears that a low serum level of vitamin D may be associated with increased MBL.