Assessing the effect of oral activated vitamin D on overall survival in hemodialysis patients: a landmark analysis
BMC Nephrology201819:309, https://doi.org/10.1186/s12882-018-1111-2
Jo-Yen Chao, Hsu-Chih Chien, Te-Hui Kuo, Yu-Tzu Chang, Chung-Yi Li, Ming-Cheng Wang and Yea-Huei Kao YangE
- Poor kidney ==> poor conversion of Vitamin D
- Very poor kidney ==> Hemodialysis (filtering of blood)
- Some Hemodialysis devices filter out Vitamin D
- Some Hemodialysis centers used to restore Vitamin D
- Hemodialysis and Vitamin D - many studies 38 studies as of Jan 2023
- Hemodialysis with low vitamin D increases risk of 2 health problems by 10 percent – Aug 2020
- Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018
- Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
- Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018
- Those Dialysis patients with low vitamin D were 75% more likely to die – July 2013
- Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis
- Vitamin D appears essential to survive many critical illnesses - review Oct 2018
- Chronic kidney treatment by Vitamin D lacks consensus: type, how much – Sept 2018
- Hypothesis: Magnesium might prevent and treat Chronic Kidney Disease – April 2018
- Hemodialysis deaths less likely if take vitamin D, especially if highest dose vitamin D – Nov 2018
Kidney category starts with
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 - Category Kidney and Vitamin D contains
229 items Download the PDF from VitaminDWiki
Deaths
per 100
person-yearAdjusted
RiskNon-users (not prescribed ?) 13 1.0 Conventional dose vitamin D 8.7 0.88 High dose vitamin D 5.9 0.66 Note: The data is for ACTIVE vitamin D prescriptions
Unknown: How many people actually took the prescription
Unknown: How many people took normal vitamin DBackground
Patients with end stage renal disease have a high all-cause and cardiovascular mortality. Secondary hyperparathyroidism and vitamin D deficiency are considered part of the mechanism for the excess mortality observed. We aimed to evaluate the relationship between vitamin D use and all-cause mortality.Methods
In this retrospective cohort study, we included all incident patients who started hemodialysis in Taiwan between 2001 and 2009. Patients were followed from landmark time, i.e., the 360th day from hemodialysis initiation, through the end of 2010 or death. We evaluated the association between activated vitamin D use or not before landmark time and all-cause mortality using conditional landmark analysis with Cox regression. We used group-based trajectory model to categorize high-dose versus average-dose users to evaluate dose-response relationships.Results
During the median follow-up of 1019 days from landmark time, vitamin D users had a lower crude mortality rate than non-users (8.98 versus 12.93 per 100 person-years). Compared with non-users, vitamin D users was associated with a lower risk of death in multivariate Cox model (HR 0.91 [95% CI, 0.87–0.95]) and after propensity score matching (HR 0.94 [95% CI, 0.90–0.98]). High-dose vitamin D users had a lower risk of death than conventional-dose users, HR 0.75 [95% CI, 0.63–0.89]. The association of vitamin D treatment with reduced mortality did not alter when we re-defined landmark time as the 180th day or repeated analyses in patients who underwent hemodialysis in the hospital setting.Conclusions: Our findings supported the survival benefits of activated vitamin D among incident hemodialysis patients.
Hemodialysis deaths less likely if take vitamin D, especially if highest dose vitamin D – Nov 2018Printer Friendly Follow this page for updates5465 visitors, last modified 20 Jan, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 10821 Hemo death user vs non user.jpg admin 10 Nov, 2018 18.97 Kb 533 10820 High dose hemodialysis.pdf admin 10 Nov, 2018 910.84 Kb 627