- Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection
- Note: Osteoarthritis affects joint cartilage, while Osteoporosis affects bones
- VitaminDWiki – Overview Osteoporosis and vitamin D contains
- VitaminDWiki – Osteoporosis category contains
- VitaminDWiki – Overview Muscles and Vitamin D contains
- 138+ VitaminDWiki pages with MUSCLE, etc in the title
- VitaminDWiki -
11 studies in both categories Seniors and Vitamin D Receptor - VitaminDWiki - Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies
Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection
Aging and disease ›› 2018, Vol. 9 ›› Issue (6) : 952-964. DOI: 10.14336/AD.2018.0215
In this study, we investigated the relationship between sarcopenia (evaluated in term of fibers atrophy), vitamin d receptor protein expression and TaqI/Cdx2/FokI VDR genotypes in an Italian cohort of osteoporosis(n=44) and osteoarthritis (n=55) patients. Muscle biopsies were fixed and investigated by both immunohistochemistry (vitamin d receptor expression) and transmission electron microscopy (satellite stem cells niches). Vitamin d receptor polymorphisms were studied on DNA extracted from muscle paraffin sections. For the first time, we reported that aging differently affects the VDR activation in OA and OP patients. In particular, while in OP patients we observed a significant reduction of VDR positive myonuclei with age, no “age effect” was observed in OA patients. The frequent activation of VDR could explain the lower number of atrophic fiber that we observed in OA patients respect to OP. From genetic point of view, we showed a putative association among polymorphisms FokI and Cdx2 of VDR gene, vitamin d receptor activation and the occurrence of sarcopenia. Altogether these data open new prospective for the prevention and cure of age-related muscle disorders.
 Download the PDF from VitaminDWiki
Note: Osteoarthritis affects joint cartilage, while Osteoporosis affects bones
VitaminDWiki – Overview Osteoporosis and vitamin D contains
- FACT: Bones need Calcium (this has been known for a very long time)
- FACT: Vitamin D improves Calcium bioavailability (3X ?)
- FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
- FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
- FACT: Vitamin D supplements are very low cost
- FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
- FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
- FACT: Co-factors help build bones.
- FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is ok
- Calcium + vitamin D is good
- Calcium + vitamin D + other co-factors is great
- Low-cost Vitamin D Receptor activators sometimes may be helpful
- CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
- Category Osteoporosis has
217 items - Category Bone Health has
308 items Note: Osteoporosis causes bones to become fragile and prone to fracture
Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
VitaminDWiki – Osteoporosis category contains
217 items in category - see also Overview Osteoporosis and vitamin D - Overview Fractures and vitamin D
- Bone - Health
308 items - VitaminDWiki pages with BONE MINERAL DENSITY or BMD in title 29+ pages
- Search VitaminDWiki for OSTEOPENIA 1740 items as of July 2020
13 articles are in both Osteroporosis and Vitamin D Receptor categories 9 articles are in both Osteroporosis and Meta-analysis categories - 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013
VitaminDWiki – Overview Muscles and Vitamin D contains
To build muscles you need more than just Vitamin D
also need Exercise, Protein, Magnesium, Omega-3, and activated Vitamin D Receptors
In fact, Vitamin D monotherapy sometimes DECREASES muscles.
Notes on Vitamin D Receptor:
Vitamin D Receptors get vitamin D in the blood to the muscle cells
Approximately 20% of people have poor vitamin D receptors
As people age, their Vitamin D receptors also become less activated
There are 12+ low-cost activators for the Vitamin D Receptor
122+ VitaminDWiki pages have MUSCLE in the title
Dr. Greger on Vitamin D and Muscles - May 2020
Vitamin D Supplements for Increasing Aging Muscle Strength- "We have known for more than 400 years that muscle weakness is a common presenting symptom of vitamin D deficiency"
- conservative "U.S. Preventive Services Task Force, the official prevention guideline setting body, and the American Geriatric Society to “recommend vitamin D supplementation for persons who are at high risk of falls.”
- AGS recommends 4,000 IU to capture 92 percent of the population"
138+ VitaminDWiki pages with MUSCLE, etc in the title
This list is automatically updated
Items found: 139
VitaminDWiki -
11 studies in both categories Seniors and Vitamin D Receptor This list is automatically updated
- Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018
- Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019
- Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019
- Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004
- Aging leads to a decrease of vitamin D getting to cells – Sept 2017
- Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017
- Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016
- 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023
- Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies
VitaminDWiki - Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies
contains Sarcopenia 1.6X more likely if you have a poor VDR – Nov 2020
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 20182343 visitors, last modified 29 Feb, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 19980 VDR Osteo.jpg admin 20 Aug, 2023 60.87 Kb 132 19979 Vitamin D Receptor in Muscle Atrophy of Elderly Patients A Key Element of Osteoporosis-Sarcopenia Connection_CompressPdf.pdf admin 20 Aug, 2023 497.85 Kb 92
- Category Bone Health has