Left ventricular adverse remodeling after myocardial infarction and its association with vitamin D levels.
Int J Cardiol. 2018 Aug 18. pii: S0167-5273(18)30354-1. doi: 10.1016/j.ijcard.2018.08.052.
Padoan L1, Beltrami AP2, Stenner E3, Beleù A1, Ruscio M3, Sinagra G1, Aleksova A4.
1 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
2 Department of Medical and Biological Sciences, University of Udine, Italy.
3 Department of Laboratory Medicine, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.
4 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy. aaleksova at units.it.
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
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- Vitamin D reduces chance of a second heart attack and death – Jan 2017
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
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- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
From the web
PDF is available free at Sci-Hub 10.1016/j.ijcard.2018.08.052.
Background: Vitamin D, a potential cardiovascular risk biomarker, has an unclear role in the adverse left ventricle remodeling (LVAR) after acute myocardial infarction (AMI).
Methods: to evaluate the impact of Vitamin D levels on LVAR in a prospective cohort study of patients with AMI.
Results: 253 patients with AMI were studied, 81 of which (32%) developed, in median 4.1 months after AMI, LVAR. Age, sex, risk factors, type and location of the infarction, clinical presentation, timing and mode of revascularization did not differ between patients with and without LVAR. However, patients with LVAR had lower Vitamin D levels (12.6 vs. 18.7 ng/mL, p <0.001), while higher Vitamin D at baseline protected against LVAR (for increase of 10 ng/ml HR 0.74, CI 0.61-0.90, p <0.001). Plasma levels of C Reactive Protein (CRP), peak Troponin I, indexed left ventricular end systolic volume (LVESVI) and NYHA class at discharge predicted, in multivariate analysis, LVAR occurrence at follow-up. Moreover, the inclusion of Vitamin D improved the multivariate model, as shown by the area under the ROC curve (HR 0.82; CI 0.76-0.88, p<0.001). During the follow-up of 25.5 (777) months, patients with LVAR had a worse event-free survival rate (HF, p=0.012; combined event HF/mortality, p=0.006), even when the analysis was restricted to patients with ST-elevation MI (p=0.006).
Conclusions: low Vitamin D levels are associated with post-infarct LVAR.
PMID: 30139699 DOI: 10.1016/j.ijcard.2018.08.052
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