- Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
- See Dementia is associated with low vitamin D - many studies
- VitaminDWiki -
14 studies in both categories Seniors and Cognitive
Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
Alzheimer’s Dement. 2023; https://doi.org/10.1002/dad2.12404
Maryam Ghahremani, Eric E. Smith, Hung-Yu Chen, Byron Creese, Zahra Goodarzi, Zahinoor Ismail
Highlights- In a prospective cohort study, we assessed effects of Vitamin D on dementia incidence in 12,388 participants from the National Alzheimer's Coordinating Center dataset.
- Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure.
- Vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment.
- Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers.
- Vitamin D has potential for dementia prevention, especially in the high-risk strata.
Introduction
Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.Methods
Baseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves compared dementia-free survival between groups. Cox models assessed dementia incidence rates across groups, adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Sensitivity analyses examined incidence rates for each vitamin D formulation. Potential interactions between exposure and model covariates were explored.Results
Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55–0.65). The effect of vitamin D on incidence rate differed significantly across the strata of sex, cognitive status, and APOE ε4 status.Discussion
Vitamin D may be a potential agent for dementia prevention.
 Download the PDF from VitaminDWiki
See Dementia is associated with low vitamin D - many studies
VitaminDWiki -
14 studies in both categories Seniors and Cognitive This list is automatically updated
- Super-Agers also have better cognition - April 2024
- Senior Cognition not improved by 2,000 IU Vitamin D avg.- RCT Aug 2023
- Seniors taking vitamin D were 40% less likely to get dementia - Jan 2023
- Higher conscientiousness, extraversion related to higher vitamin D in seniors – Feb 2023
- Increased risk of many neuro problems after COVID (1.4 X youths, 1.2X seniors) – Aug 2022
- Less cognitive decline in older blacks getting 2,000 IU of vitamin D daily for years (VITAL, etc. post analysis) – RCT Dec 2021
- Less cognitive decline in women consuming more Magnesium (and vitamins) – Nov 2019
- Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019
- Dementia is associated with low vitamin D - many studies
- Delirium in Hospitalized Older Adults (does not mention low vitamin D relationship) NEJM Oct 2017
- Low vitamin D with metabolic syndrome increased risk of senior cognitive impairment by 3X – July 2016
- Omega-3 etc improved both cognition and mobility of older women – Aug 2015
- 80 year olds had better cognition and stood better if high level of vitamin D – Sept 2012
- Overview Alzheimer's-Cognition and Vitamin D
Seniors taking vitamin D were 40% less likely to get dementia - Jan 20232163 visitors, last modified 28 Jul, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 19858 dementia and D.jpg admin 28 Jul, 2023 41.77 Kb 121 19857 dementia and D.pdf admin 28 Jul, 2023 1,011.91 Kb 62