- Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials
42 Virus Meta-analyses
Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials
Front. Pharmacol., 26 May 2024 Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1367686
Yiyuan YangYiyuan YangWanli SunWanli SunFan YangFan YangGuoxia ZhangGuoxia ZhangXinye LiXinye LiShipeng Sun
Shipeng Sun*Yanwei Xing
Yanwei Xing* Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Background: The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis of randomized controlled trials (RCTs).Methods: Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web of Science and Embase. RCTs assessing mortality,
- intensive care unit (ICU) admission,
- mechanical ventilation (MV),
- length of hospitalization (LOH), and
- inflammatory markers containing
- C-reactive protein (CRP),
- D-dimer,
- interleukin-6 (IL-6),
- lactate dehydrogenase (LDH) were included.
19 RCTs were involved in the analysis and were conducted subgroup analyses on the baseline COVID-19 severity and vitamin D administration.
Results: In the severity subgroup, statistically significant effects in moderate to severe group were observed in
- ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008),
- MV (OR 0.44, 95% CI 0.27, 0.72; p = 0.001) and
- LOH (SMD –0.49, 95% CI –0.92, −0.06; p = 0.027).
In the administration subgroup,
- effects of ICU admission (OR 0.39, 95% CI 0.16, 0.97; p = 0.044),
- MV (OR 0.18, 95% CI 0.07, 0.46; p = 0.000) and
- LOH (SMD –0.50, 95% CI –0.96, −0.04; p = 0.034)
were more pronounced in patients supplied with multiple-dose vitamin D than single-dose. Although the result of mortality showed no statistically significant effect, it indicated a reduced trend (OR 0.87, 95% CI 0.63, 1.12; p > 0.05). The results of inflammatory markers reached no statistical differences.
Conclusion: This meta-analysis revealed that moderate to severe COVID-19 patients supplied with multiple doses of vitamin D were less apt to need ICU admission, mechanical ventilation and have shorter hospital stays.
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study was reviewed in Trial Site News
42 Virus Meta-analyses Short URL for this section = is.gd/vdwmeta
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