- Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond
- Risk of 44+ diseases at least double with poor Vitamin D Receptor
- 81+ Vitamin D Receptor pages in VitaminDWiki have CANCER in title
- 14 ways Vitamin D Receptor activation can be increased
- VitaminDWiki - The Vitamin D Receptor is associated with many health problems contains
- VitaminDWiki -
24 studies in both categories Diabetes and Vitamin D Receptor - 6 Reasons that medical professionals do not prescribe Vitamin D for Diabetes
Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond
Nutrients 2023, 15, 1997. https: / / doi.org/ 10.3390/nu15081997
Jie Wu 1 , Annette Atkins 2, Michael Downes * and Zong Wei 1,3,*- Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
- Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
- Division of Endocrinology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
* Correspondence: downes at salk.edu (M.D.); wei.zong at mayo.edu (Z.W.)
Over the last decades, epidemiology and functional studies have started to reveal a pivotal role of vitamin D in both type 1 and type 2 diabetes pathogenesis. Acting through the vitamin D receptor (VDR), vitamin D regulates insulin secretion in pancreatic islets and insulin sensitivity in multiple peripheral metabolic organs. In vitro studies and both T1D and T2D animal models showed that vitamin D can improve glucose homeostasis by enhancing insulin secretion, reducing inflammation, reducing autoimmunity, preserving beta cell mass, and sensitizing insulin action.
Conversely, vitamin D deficiency has been shown relevant in increasing T1D and T2D incidence. While clinical trials testing the hypothesis that vitamin D improves glycemia in T2D have shown conflicting results, subgroup and meta-analyses support the idea that raising serum vitamin D levels may reduce the progression from prediabetes to T2D.
In this review, we summarize current knowledge on the molecular mechanisms of vitamin D in insulin secretion, insulin sensitivity, and immunity, as well as the observational and interventional human studies investigating the use of vitamin D as a treatment for diabetes.
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Risk of 44+ diseases at least double with poor Vitamin D Receptor
81+ Vitamin D Receptor pages in VitaminDWiki have CANCER in title
14 ways Vitamin D Receptor activation can be increased
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
VitaminDWiki - The Vitamin D Receptor is associated with many health problems contains
Health problems include: Autoimmune (19 studies), Breast Cancer ( 22 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 12 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 36 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
VitaminDWiki -
24 studies in both categories Diabetes and Vitamin D Receptor This list is automatically updated
- T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Resveratrol improves health (Vitamin D receptor, etc.)
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
6 Reasons that medical professionals do not prescribe Vitamin D for Diabetes
- No profit for Big Pharma
Diabetes - A Lucrative Disease April 2023 - Less income for doctors or hospitals if stop diabetes
- The Vitamin D dose needed often varies by 4X between individuals for many health problems
Doctors prefer using a single dose of a drug for all patients - Doctors are unaware that small doses of vitamin D gut-friendly can be used
Gut-Friendly Vitamin D is available on Amazon, but not in pharmacies, nor by prescription
they are uncomfortable prescribing 4,000+ IU of vitamin D
in many countries, doctors can only prescribe D2 (which does not work as well), not D3 - Doctors are unaware that adding Magnesium helps prevent/treat Diabetes
they often just want to use a monotherapy - Doctors are unaware that sometimes the Vitamin D Receptors also need to be activated
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