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Overview Pain and Vitamin D


24+ VitaminDWiki pages have both PAIN and RCT in their title

This list is automatically updated

Items found: 24
Title Modified
Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 27 Aug, 2023
Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023 22 Jul, 2023
Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012 17 Jul, 2023
Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016 23 Sep, 2021
Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020 25 Jul, 2020
Lower back pain treated by 600,000 IU of Vitamin D – RCT June 2019 28 Jun, 2019
Knee pain and depression reduced by monthly 50,000 IU vitamin D – RCT April 2018 21 Apr, 2018
Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018 02 Mar, 2018
Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021 18 Oct, 2017
Long-term lower back pain greatly reduced by Magnesium - RCT 2013 29 May, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Raynaud's pain decreased with 20,000 IU daily average vitamin D – RCT May 2012 05 Dec, 2016
Less use of musculoskeletal pain drugs if get vitamin D (no dose information)– RCT Feb 2015 20 Nov, 2016
Menstrual Pain reduced by vitamin D – RCT Feb 2012 07 May, 2016
Back pain not relieved when vitamin D levels remained below 30 nanograms – RCT Nov 2015 04 Dec, 2015
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 05 Nov, 2015
Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015 05 Nov, 2015
Pain not reduced by vitamin D (only used 1,000 IU) - RCT Dec 2014 16 Jul, 2015
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 24 May, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 22 Nov, 2014
Dark skinned in Norway: 1000 IU vitamin D not enough to reduce pain – RCT Sept 2014 28 Sep, 2014
150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012 17 Sep, 2014
Pain reduction with 600,000 IU Vitamin D: RCT announced Dec 2013 06 Dec, 2013
Just 500 IU of vitamin D helped reduce rheumatoid arthritis pain - RCT Oct 2011 07 Sep, 2012

Chronic Pain

Pain sources vs. Vitamin D - Jan 2025

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Fibromyalgia and Widespread


Rheumatoid Arthritis

Headache Pain

Dark Skin Pain

Other Pain

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Pain - chronic category has the following

169 items in category Chronic pain

See also


32 Items in both of the categories Pain and Intervention:


VitaminDWiki - Proof that Vitamin D Works (93+)

includes: Back Pain,   Raynaud's Pain,   Menstrual Pain,   Rheumatoid Arthritis,   Sickle Cell Pain,   Fibromyalgia   Knee pain   Growing Pain  Headache Pain
Note: Many pains are not treated by 1 pill every 2 weeks - they need 1 pill every week


Serious chronic pain list from Institute of Medicine (all helped by Vitamin D)

  • Migraine and other serious headaches,
  • Arthritis and other joint pain,
  • Endometriosis,
  • Irritable bowel syndrome,
  • Trauma or postsurgical pain
  • Lower-back pain,
  • Shingles,
  • Sickle-cell disease,
  • Heart disease (angina),
  • Cancer,
  • Stroke

Vitamin D and Chronic Pain - Nov 2013

The health Haven

  • People with inadequate vitamin D blood levels will need to take twice as much narcotic pain medication as those with adequate vitamin D for pain relief. So, while vitamin D does not cure chronic pain, it is an important adjuvant therapy to use in pain treatment management.
  • Research studies on vitamin D have shown that many types of fatigue and chronic pain are linked to vitamin D deficiency, including chronic musculoskeletal pain, fibromyalgia syndrome, osteoarthritis, migraine headaches, rheumatic pain and hyperesthesia.
  • 'For patients who do not respond to other therapy, vitamin D supplementation is recommended to alleviate or perhaps even resolve chronic fatigue and pain issues

Vitamin D - A Neglected 'Analgesic' for Chronic Musculoskeletal Pain- An Evidence-Based Review & Clinical Practice Guidance - 2008

Pain-Topics.org 2008, Author: Stewart B. Leavitt, MA, PhD
Medical Reviewers Bruce Hollis, PhD; Michael F. Holick, MD, PhD; Seth I. Kaufman, MD; Lee A. Kral, PharmD, BCPS; Paul W. Lofholm, PharmD, FACA; N. Lee Smith MD; James D. Toombs, MD; Winnie Dawson, RN, BSN, MA
 Download the PDF from VitaminDWiki.
Elderly Skin generates less Vitamin D Derived from chart in that study
Elderly skin generates less vitamin D


Pain relievers can extend duration of back pain - and sometimes turning it into a chronic pain - May 2022

Common Medications Can Prolong Back Pain, Study Says New York Times

  • "Guidelines from professional medical societies already say that people with back pain should start with nondrug treatments like exercise, physical therapy, heat or massage. Those measures turn out to be as effective as pain-suppressing drugs, without the same side effects."
  • Biobank stiudy found ...2,163 people with acute back pain, 461 of whom went on to have chronic pain. Those taking a nonsteroidal anti-inflammatory had nearly double the chance of developing chronic back pain as those taking other drugs or no drugs, the researchers found.
  • "An analysis of randomized clinical trials found that these drugs had almost no benefit over placeboes in reducing low back pain."

Study - Acute inflammatory response via neutrophil activation protects against the development of chronic pain PDF


People in pain having low vitamin D levels will benefit from supplementation - Oct 2017

Vitamin D in Pain Management - review
 Download the PDF from VitaminDWiki


See also web

Brief pain summary May 2016
The Opioid Epidemic We Failed to Foresee New York Times

I (Henry Lahore) sent the following comment to NYT

WOMEN'S PAIN IS DIFFERENT FROM MEN'S—THE DRUGS COULD BE TOO Wired Mag March 2019

  • Nothing about Vitamin D. Virtually all pain research has been on maile animals

Mercola Review of Acupuncture for pain relief Aug 2017 nothing about vitamin D

  • 2002 WHO review
  • 2004 of 29 studies found 50% reduction in pain levels
  • 2015 BBC Video
  • Recent acupuncture study discovered Nitric Oxide (NO) at the points

Alternatives to Drugs for Treating Pain NYT Sept 2017

  • Pain of headaches, back, sciatica, etc, are sometimes due to muscle tension.
  • Reducing the muscle tension thru relaxation (meditation, yoga, etc) often help
  • The article references include
    "Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians" - April 2017 full text online
    "Evidence-Based Evaluation of Complementary Health Approaches for Pain Management in the United States" May 2016 free PDF on-line
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    Personal note: They do not seem to mention additional ways I have found to eliminate various pains in 10 minutes.

Pain Factoids from the Body by Bill Bryson, 2019

  • Chronic pain has no purpose. It’s just a system gone wrong, in the same way that cancer is a system gone wrong. We now believe that many types of chronic pain are diseases in their own right, something quite separate from acute pain.”
  • The International Classification of Headache Disorders recognizes fourteen categories of headaches—migraine, trauma-induced headache, infection-induced headache, disorder of homeostasis, and so on.
  • According to the U.S. Institute of Medicine, part of the National Academy of Sciences, about 40 percent of adult Americans—100 million people—are experiencing chronic pain at any given moment.
  • Altogether chronic pain affects more people than cancer, heart disease, and diabetes combined.
  • Andrew Rice, a pain researcher at Imperial College London, told Nature in 2016, “The drugs we have relieve 50 percent of pain in somewhere between one in four and one in seven of the patients we treat. That’s for the best drugs.” In other words, some 75 percent to 85 percent of people get no benefit at all from even the best pain drugs, and those who do get benefit don’t usually get much.

Pain is associated with other categories: Intervention, 33, Osteoarthritis 9, Loading dose 7, Skin - Dark 7, Magnesium 7, Seniors 7, Sleep,7, etc

Back pain, 6, Cancer - after diagnosis, 5, Osteoporosis, 5 (as of Nov 2023)

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Summary of Associations

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Results

8 pages in both categories: Pain - chronic + Back pain

32 pages in both categories: Pain - chronic + Intervention

Page Hits Categories Major change
Knee osteoarthritis treated by Vitamin D - many studies Pain - chronic, Intervention, Osteoarthritis 13 Dec, 2023
Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023 2334 Pain - chronic, Intervention, Intervention - non daily 04 Oct, 2023
Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg) – Aug 2023 327 Pain - chronic, Intervention, Intervention - non daily 15 Aug, 2023
Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023 374 Pain - chronic, Intervention, Intervention - non daily 22 Jul, 2023
Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012 62513 Pain - chronic, Intervention, Intervention - non daily 17 Jul, 2023
Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016 5102 Pain - chronic, Intervention, Women 23 Sep, 2021
Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months – May 2021 2562 Pain - chronic, Vitamin D and Calcium, Intervention, Intervention - non daily 16 Jul, 2021
Quality of Life 28527 Pain - chronic, Intervention, Category , Quality of Life 25 Jul, 2020
Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013 2165 Bone - Health, Pain - chronic, Loading dose for Vitamin D, Intervention, Injection 25 Jul, 2020
Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020 3239 Diabetes, Pain - chronic, Loading dose for Vitamin D, Intervention, Injection 25 Jul, 2020
Dysmenorrhea substantially reduced by Ginger, just 1,000 IU Vitamin D also helped – RCT Nov 2019 5840 Pain - chronic, Intervention, Women 02 Dec, 2019
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 9330 Pain - chronic, Intervention, Top news, Intervention - non daily, Quality of Life 19 Oct, 2019
Growing pains reduced 60 percent by monthly Vitamin D – March 2014 12288 Pain - chronic, Intervention, Infant-Child, Intervention - non daily 19 May, 2019
100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018 4213 Pain - chronic, Intervention, Intervention - non daily 25 Dec, 2018
Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018 3474 Pain - chronic, Rheumatoid Arthritis, Intervention, Intervention - non daily 05 Oct, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 6956 Pain - chronic, Intervention, Top news, Intervention - non daily 23 Jun, 2018
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 10094 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 20 Jul, 2017
Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015 8975 Cardiovascular, Pain - chronic, Intervention, Intervention - non daily, Injection 05 Apr, 2017
Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016 8893 Pain - chronic, Loading dose for Vitamin D, Intervention 27 Feb, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 6756 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 24 Dec, 2016
Less use of musculoskeletal pain drugs if get vitamin D – Feb 2015 3584 Pain - chronic, Intervention 20 Nov, 2016
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 33279 Pain - chronic, Intervention, Top news 05 Nov, 2015
Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015 17438 Pain - chronic, Lupus, Intervention 05 Nov, 2015
Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015 12042 Diabetes, Pain - chronic, Intervention, Intervention - non daily 22 Oct, 2015
High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 18750 Pain - chronic, Rheumatoid Arthritis, Osteoporosis, Intervention, High-Dose 11 Jul, 2015
Growing pains reduced 57 percent by vitamin D therapy – May 2015 8694 Pain - chronic, Intervention, Infant-Child 28 May, 2015
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 6148 Pain - chronic, Cancer - after diagnosis, Intervention 24 May, 2015
400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014 21005 Pain - chronic, Loading dose for Vitamin D, Intervention 28 Apr, 2015
Pain reduced when enough vitamin D was given – review March 2015 7331 Pain - chronic, Intervention 19 Mar, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 18827 Pain - chronic, Intervention, Intervention - non daily 22 Nov, 2014
150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012 6378 Skin - Dark, Pain - chronic, Intervention 17 Sep, 2014
7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012 18387 Pain - chronic, Intervention, Top news, Sleep, Intervention - non daily 20 Aug, 2014

16 pages in both categories: Pain - chronic + Intervention - non daily

Page Hits Categories Major change
Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023 2334 Pain - chronic, Intervention, Intervention - non daily 04 Oct, 2023
Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg) – Aug 2023 327 Pain - chronic, Intervention, Intervention - non daily 15 Aug, 2023
Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023 374 Pain - chronic, Intervention, Intervention - non daily 22 Jul, 2023
Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012 62513 Pain - chronic, Intervention, Intervention - non daily 17 Jul, 2023
Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months – May 2021 2562 Pain - chronic, Vitamin D and Calcium, Intervention, Intervention - non daily 16 Jul, 2021
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 9330 Pain - chronic, Intervention, Top news, Intervention - non daily, Quality of Life 19 Oct, 2019
Growing pains reduced 60 percent by monthly Vitamin D – March 2014 12288 Pain - chronic, Intervention, Infant-Child, Intervention - non daily 19 May, 2019
100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018 4213 Pain - chronic, Intervention, Intervention - non daily 25 Dec, 2018
Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018 3474 Pain - chronic, Rheumatoid Arthritis, Intervention, Intervention - non daily 05 Oct, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 6956 Pain - chronic, Intervention, Top news, Intervention - non daily 23 Jun, 2018
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 10094 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 20 Jul, 2017
Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015 8975 Cardiovascular, Pain - chronic, Intervention, Intervention - non daily, Injection 05 Apr, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 6756 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 24 Dec, 2016
Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015 12042 Diabetes, Pain - chronic, Intervention, Intervention - non daily 22 Oct, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 18827 Pain - chronic, Intervention, Intervention - non daily 22 Nov, 2014
7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012 18387 Pain - chronic, Intervention, Top news, Sleep, Intervention - non daily 20 Aug, 2014

7 pages in both categories: Pain - chronic + Skin - Dark

5 pages in both categories: Pain - chronic + Cancer - after diagnosis

4 pages in both categories: Pain - chronic + Trauma and surgery

8 pages in both categories: Pain - chronic + Loading dose for Vitamin D

6 pages in both categories: Pain - chronic + Infant-Child

10 pages in both categories: Pain - chronic + Top news

Page Hits Categories Major change
Vitamin D at CureTogether: Fibromyalgia, MS, Psoriasis, etc - Dec 2013 2830 Multiple Sclerosis, Pain - chronic, Psoriasis, Top news 11 Jul, 2023
Large dose Vitamin D before surgery was found to help by 35 studies 312 Pain - chronic, Trauma and surgery, Loading dose for Vitamin D, Top news, High-Dose 08 May, 2023
Magnesium reduces pain - many studies 14162 Pain - chronic, Vitamin D and Magnesium, Top news 19 May, 2022
Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019 7284 Diabetes, Pain - chronic, Vitamin D and Magnesium, Top news 28 Nov, 2021
Less labor pain if higher level of vitamin D – August 2021 3942 Pregnancy, Pain - chronic, Top news 10 Aug, 2021
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 9330 Pain - chronic, Intervention, Top news, Intervention - non daily, Quality of Life 19 Oct, 2019
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 6956 Pain - chronic, Intervention, Top news, Intervention - non daily 23 Jun, 2018
Trigger points (myofascial pain) may be associated with low Vitamin D and low Magnesium – Jan 2018 6791 Pain - chronic, Vitamin D and Magnesium, Top news 16 Jan, 2018
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 33279 Pain - chronic, Intervention, Top news 05 Nov, 2015
7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012 18387 Pain - chronic, Intervention, Top news, Sleep, Intervention - non daily 20 Aug, 2014

8 pages in both categories: Pain - chronic + Sleep

10 pages in both categories: Pain - chronic + Osteoarthritis

Page Hits Categories Major change
60% people surveyed with rheumatic conditions are switching to medical cannabis – Nov 2024 22 Pain - chronic, Lupus, Rheumatoid Arthritis, Osteoporosis, Osteoarthritis, AI 07 Nov, 2024
Jaw joint (TMJ) needs 30-50 ng of Vitamin D and a good VDR – April 2021 Pain - chronic, Osteoarthritis, Optimum, Vitamin D Receptor 17 Oct, 2024
Knee osteoarthritis treated by Vitamin D - many studies Pain - chronic, Intervention, Osteoarthritis 13 Dec, 2023
Ageing faster and more knee pain are associated with low vitamin D – March 2022 726 Pain - chronic, Osteoarthritis 08 Mar, 2022
Muscle problems are both treated and avoided by Vitamin D – April 2018 7243 Seniors, Sports and Vitamin D, Pain - chronic, Osteoarthritis 03 Jul, 2018
Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018 3046 Pain - chronic, Rheumatoid Arthritis, Headache, Meta-analysis of Vitamin D, Osteoarthritis, Back pain 08 Apr, 2018
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 10094 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 20 Jul, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 6756 Pain - chronic, Intervention, Osteoarthritis, Intervention - non daily 24 Dec, 2016
Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014 5129 Pain - chronic, Osteoarthritis 27 Oct, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 4524 Obesity, Pain - chronic, Osteoarthritis 12 Apr, 2015

4 pages in both categories: Pain - chronic + Bone - Health

7 pages in both categories: Pain - chronic + Vitamin D and Magnesium

7 pages in both categories: Pain - chronic + Seniors

4 pages in both categories: Pain - chronic + Multiple Sclerosis

6 pages in both categories: Pain - chronic + Osteoporosis

6 pages in both categories: Pain - chronic + Rheumatoid Arthritis

4 pages in both categories: Pain - chronic + Diabetes

4 pages in both categories: Pain - chronic + Women

4 pages in both categories: Pain - chronic + Off Topic

4 pages in both categories: Pain - chronic + AI

Short URL for this page = http://is.gd/painvitamind

Overview Pain and Vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
18858 Pain 60,000 month RCT.pdf admin 25 Nov, 2022 376.11 Kb 330
17601 chronic pain and pain relievers_CompressPdf.pdf admin 15 May, 2022 804.88 Kb 435
8971 VITAMIN D DEFICIENCY AND CHRONIC WIDESPREAD PAIN.pdf admin 20 Dec, 2017 135.21 Kb 5004
8581 Vitamin D and Pain.pdf admin 24 Oct, 2017 221.67 Kb 1406
8412 Mayo pain summary.jpg admin 11 Sep, 2017 72.12 Kb 4233
8411 Mayo Pain.jpg admin 11 Sep, 2017 26.26 Kb 4075
7883 Opioid addiction.jpg admin 28 Mar, 2017 30.38 Kb 4542
3151 Pain Topics vitamind June 2008.pdf admin 20 Oct, 2013 769.94 Kb 3065
2351 PAIN from GrassRoots survey.jpg admin 13 Apr, 2013 68.26 Kb 7764
2158 Pain - 2013 non specific.pdf admin 02 Mar, 2013 119.45 Kb 2472