- 55+ VitaminDWiki pages with BONE MINERAL DENSITY or BONE LOSS in the title
- Meta-analysis of Vitamin D and Bone Mineral Density - April 2023
- Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency – Sept 2024
- VitaminDWiki – Bone - Health category contains
- VitaminDWiki – Overview Osteoporosis and vitamin D contains
- VitaminDWiki -
32 studies in both categories Bone AND Osteoporosis - There have been
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55+ VitaminDWiki pages with BONE MINERAL DENSITY or BONE LOSS in the title
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Meta-analysis of Vitamin D and Bone Mineral Density - April 2023
Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Nutr Rev . 2023 Apr 11;81(5):511-530. doi: 10.1093/nutrit/nuac068 behind publisher paywall
Elham Kazemian 1, Ali Pourali 2, Fatemeh Sedaghat 3, Mehrdad Karimi 4, Vahid Basirat 5, Zohreh Sajadi Hezaveh 6 7, Sayed Hossein Davoodi 7, Michael F Holick 8
Context: There is still controversy over the effect of vitamin D3 supplementation on bone health.Objective: The effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3 and bone health in adults, were evaluated.
Data sources: The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria.
Data extraction: Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3 for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3 supplementation and BMD.
Data analysis: Results of meta-analysis showed a beneficial effect of vitamin D3 at the
- lumbar spine (standardized mean difference [SMD] = 0.06; 95%CI, 0.01-0.12) and
- femoral neck (SMD = 0.25; 95%CI, 0.09-0.41).
Dose-response analysis revealed a linear relationship between vitamin D3 supplementation doses and
- BMD at the femoral neck,
- lumbar spine, and
- total hip sites.
No significant effect of vitamin D3 supplementation on whole-body or total hip BMD was observed (P > 0.05). Vitamin D3 supplementation significantly decreased BMD at both proximal and distal forearm (SMD = -0.16; 95%CI, -0.26 to -0.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3 dosing frequency, and bone health status (P interaction = 0.02) altered the effect of vitamin D3 supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3 supplement doses and markers of bone turnover was found.
Conclusion: A protective effect of vitamin D3 supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.
Accelerated bone loss in late reproductive-aged and perimenopausal women with vitamin D insufficiency – Sept 2024
Journal of Bone and Mineral Metabolism PDF behind paywall
Min-Jeong Kim, Sunmie Kim, Jin Ju Kim & Kyung Hee HanIntroduction
The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.Materials and methods
We analyzed data from 586 generally healthy Korean women aged 29–79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015–2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.Results
The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.Conclusions
Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.
VitaminDWiki – Bone - Health category contains
311 items in Bone - Health category
See also- Overviews: Osteoporosis, Fractures, Rickets Dental Hair
-
16 articles are in both Bone and Magnesium categories 29 articles are in both Bone and Vitamin K2 categories 17 articles are in both Bone and Sports categories 8 articles are in both Bone and Meta-analysis categories 25 articles are in both Fractures and Meta-analysis categories - Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- VitaminDWiki pages with BONE MINERAL DENSITY or BMD in title 25 pages as of Feb 2023
- Hearing loss is associated with soft bones in ear
- Perhaps prevented and treated by Vitamin D
- See also Overview of Rickets and Vitamin D Overview Osteoporosis and vitamin D
VitaminDWiki – Overview Osteoporosis and vitamin D contains
- FACT: Bones need Calcium (this has been known for a very long time)
- FACT: Vitamin D improves Calcium bioavailability (3X ?)
- FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
- FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
- FACT: Vitamin D supplements are very low cost
- FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
- FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
- FACT: Co-factors help build bones.
- FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
- It appears that to TREAT Osteoporosis:
- Calcium OR vitamin D is ok
- Calcium + vitamin D is good
- Calcium + vitamin D + other co-factors is great
- Low-cost Vitamin D Receptor activators sometimes may be helpful
- CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
- Category Osteoporosis has
218 items - Category Bone Health has
311 items Note: Osteoporosis causes bones to become fragile and prone to fracture
Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
VitaminDWiki -
32 studies in both categories Bone AND Osteoporosis This list is automatically updated
- Potassium helps bones by increasing the absorption of both Calcium and Vitamin D – Feb 2024
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Osteoporosis has no symptoms until a bone breaks
- History of Vitamin D from 500 million years ago to orthopaedic practice today – 2019
- Hard bones, soft arteries, rather than vice versa (Vitamin D and Vitamin K) – March 2016
- Solar and nutritional Osteomalacia (soft bones at all stages of life) – Jan 2019
- Diagnosis and treatment of osteopenia – Holick 2010
- Higher Omega-3 intake associated with less bone pain – Jan 2018
- Bone loss (following gastric cancer) reduced by 16,000 IU of vitamin D every 10 days – Aug 2017
- Bone diseases related to many Vitamin D diseases – June 2016
- Bones not helped much by vitamin D (low dose or short term) National Osteoporosis Foundation – Feb 2016
- Better bones again associated with higher vitamin K intake – Nov 2015
- Vitamin D, Calcium and protein very important to bone health – Sept 2015
- Breast Feeding increased risk of low bone density by 24 percent – Sept 2015
- 800 IU Vitamin D proven again to not be enough to stop bone loss - Aug 2015
- Vitamin K and bone health – need more research Oct 2013
- Both Vitamin D and Calcium are needed to reduce bone loss – RCT Sept 2013
- 22 percent more bone cracking found with low vitamin D – July 2013
- 3D images of bone plus position statements on Osteo and vitamin D – 2012
- Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012
- Vitamin D is the first of three ways to make unbreakable bones – Oct 2011
- Forum on Aging and Skeletal Health – Sept 2011
- BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K – April 2011
- Hardly any children had enough vitamin D before bone surgery – April 2011
- Overview Fractures and vitamin D
- Overview Osteoporosis and vitamin D
- Low Calcium and vitamin D makes osteomalacia but either makes osteoporosis – Sept 2010
- Fewer bone and stress fractures with vitamin D - many studies
- Better total hip replacement if have high vitamin D
- Bone Health and Vit D: Evidence Based Review 2007
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