Low Magnesium associated with severe COVID – many studies

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Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients? –March 2022

Front. Endocrinol. 13:843152. doi: 10.3389/fendo.2022.843152
Mark Eskander and Mohammed S. Razzaque
Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, United States

The coronavirus disease (COVID-19) caught the world by surprise, claiming millions of lives due to its deadly effects. Ongoing research studies evaluate the measures that can reduce the severity of symptoms in patients infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Magnesium is an essential nutrient that has many studied benefits in humans. This brief commentary aims to describe the potential benefits of magnesium on COVID-19 patients and the reported effects of low versus high magnesium levels in SARS-CoV-2 infected individuals. Also, the potential benefits of vitamin D and how magnesium acts as a cofactor to activate vitamin D functions are elaborated. The results of the existing studies point towards evidence that magnesium may have significant benefits in reducing the severity of COVID-19 symptoms. There is also evidence that magnesium-dependent vitamin D activities may have antiviral effects, thus potentially being able to reduce rates of COVID-19 infection, which is a hypothesis that should be further tested.

The COVID-19 primarily causes respiratory distress but has a broad range of other clinical manifestations and affects various organs and systems in the body. COVID-19 is especially lethal to elderly populations at higher risk (1,2). As of September 3rd, 2021, the current worldwide death rate of individuals infected by COVID-19 is 4,539,723 (World Health Organization). Many public health measures have already been taken to try to prevent the spread of COVID-19, such as face mask mandates, vaccine inoculation, quarantine, social distancing, limited capacities at public venues, and a shift to online work. However, COVID-19 is still proving to be a health concern as cases of infection continue to rise. The continued infection of individuals by COVID-19 may be due to the high transmissibility of the virus (3-6). It is also proposed that some of the new variants of the virus are even more rapidly transmissible and lethal. Thus, certain preventative measures are essential to find to reduce the severity of symptoms and improve patient outcomes in individuals that have been infected, since the prevention of infection is not always possible.

Basic nutrients that optimize physiologic functions in the body, such as magnesium, maybe used as a prophylactic measure that can improve patient outcomes in individuals infected by SARS-CoV-2, and potentially even reduce the intensity of the infection by the virus by potentiating vitamin D functions. In the U.S., more than 50% of people are magnesium deficient (7, 8), and magnesium deficiency is also prevalent in many other countries. The low level of magnesium in the general population may make individuals more vulnerable to viral insults. The high prevalence of magnesium deficiency makes it important to determine how optimal and suboptimal magnesium levels affect COVID-19 patient outcomes, which this paper aims to elaborate on.
 Download the PDF from VitaminDWiki

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10 Magnesium and COVID articles

• Magnesium -The neglected cation in COVID-19? - Jan–Mar 2021 https://doi.org10.4103/joacp.JOACP_628_20 FREE PDF
• Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness - July 2021, https://doi.org/10.34067/KID.0002592021 FREE PDF
• Association between Hypomagnesemia, COVID-19, Respiratory Tract and Lung Disease- Sept 2021 https://doi.org10.2174/1874306402115010043 PDF?
• Effect of magnesium on severity and mortality of COVID–19 patients: A systematic review - Sept 2022 https://doi.org/10.4103/2221-6189.355308 FREE PDF
• Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study - May 2022 https://doi.org/10.3389/fnut.2022.873162 FREE PDF
• Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients? - March 2022 https://doi.org/10.3389/fendo.2022.843152 FREE PDF
• The potential role of zinc, magnesium and selenium against COVID-19: a pragmatic review - Jul 2021 https://doi.org/10.1080/2574254X.2021.1941706 FREE PDF
• The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19 - April 2021 : https://doi.org/10.1684/mrh.2021.0479 FREE PDF
• The relevance of magnesium homeostasis in COVID-19 - Oct 2021 https://doi.org/10.1007/s00394-021-02704-y FREE PDF
• Magnesium therapeutic potential against Covid-19: Could it be an "All-in-one" therapy ? letter to editor - Date?  PDF

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VitaminDWiki - 26 studies in both categories Virus and Magnesium

This list is automatically updated

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VitaminDWiki - Magnesium and Vitamin D contains

363 items in category, see also

• Overview Magnesium and vitamin D
• Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
• The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
• Magnesium deficiency – causes and symptoms – May 2016
• Magnesium Depletion Score predicts increased risk of various health problems
• Vitamins and Metals needed by the Immune System – Jan 2020
• Magnesium: intake decreased, difficult to measure in body – Sept 2018
• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
• Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
• Magnesium is important for health but levels are low – July 2018
• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
• Magnesium etc. reduced in crops (must supplement) – 2009

Mg and Vitamin D

• Intracellular Magnesium and Vitamin D - a few studies
• Vitamin D and Magnesium need each other - many studies
• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
• Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
• Vitamin D Cofactors in a nutshell
• Magnesium and Vitamin D - similar, different and synergistic

Magnesium topics gathered on a page

• Vitamin D, Omega-3, and Magnesium are synergistic - many studies
• Magnesium and Cancer - many studies
• Diabetes, Metabolic Syndrome and Magnesium - many studies
• Low Magnesium associated with severe COVID – many studies
• Calcium to Magnesium Ratio - many studies
• Magnesium Role in Health and Longevity - many studies
• Magnesium reduces pain - many studies
• Vitamin D and Magnesium need each other - many studies
• Pregnancy helped by Magnesium - many studies

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Role of Magnesium in Acute and Long COVID - Drbeen video Jan 2023

YouTube 41 minutes

Magnesium is an essential mineral/nutrient required for more than 600 enzymatic actions in our body. Magnesium levels are also tied closely with the activation of vitamin D. Magnesium is involved in smooth muscle relaxation, neuroprotection, innate arm modulation, gut microbiome modulation, and much more. Let's look at the role of magnesium and importance of its levels to be correct in our body. If you like this content and want more, I am doing a special lifetime membership offer.
Click here: https://www.drbeen.com/yt-special-p/ Want to support this work?: Buy me a coffee https://www.buymeacoffee.com/DrMobeen... Become my patron: https://www.patreon.com/mobeensyed?fa... PayPal: https://paypal.me/mobeensyed?locale.x... My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #COVID
sDisclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. URL list from Monday, Jan. 23 2023

Frontiers | Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study https://www.frontiersin.org/articles/...

The relevance of magnesium homeostasis in COVID-19 - PMC https://www.ncbi.nlm.nih.gov/pmc/arti...

Frontiers | Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients? https://www.frontiersin.org/articles/...

Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... 

The Role of Magnesium in Neurological Disorders - PMC https://www.ncbi.nlm.nih.gov/pmc/arti...

Neural Mechanisms of Autonomic Dysfunction in Neurological Diseases https://www.hindawi.com/journals/np/2...

Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+ without changing intracellular Mg2+. - PMC https://www.ncbi.nlm.nih.gov/pmc/arti...

Frontiers | The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response https://www.frontiersin.org/articles/...

Short URL = https://is.gd/mgcovid