Vitamin D, autoimmunity and gender
Curr Med Chem. 2016 Dec 19. [Epub ahead of print]
Crescioli C1, Minisola S.
1Department of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy.
Autoimmune category starts with
204 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Lupus Psoriasis
- Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
- 10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
- Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
- All 43 references are FREE on-line
- Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
- The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
- The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- More autoimmune disease if higher pollution or lower UVB - Feb 2023
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:
See also webAutoimmune Diseases have been increasing - Oct 2015
BACKGROUND:
Vitamin D deficiency is considered a risk factor for autoimmune diseases. Vitamin D and its analogues have been proposed as therapeutic tools in autoimmunity considering their exquisite immunoregulatory effect against over-reactivity towards tolerance. Autoimmune diseases, nowadays recognized as emerging non communicable diseases, are characterized by a significant female bias. This sexual dimorphism seems related to sex hormones, which differently affect male and female immune systems.- Males show higher immunosuppression, maybe due to androgens;
- the greater female immunoreactivity and competence, likely related to estrogens, lead to a greater resilience to infections but also to a higher risk for autoimmunity.
Higher interest could be given to vitamin D-based supplementation or therapy for autoimmune diseases in relation to gender as well.
OBJECTIVE:
This review aims to discuss the role of vitamin D in autoimmune diseases with a view inside gender-related differences, in light of the interplay between vitamin D and sex hormones, especially estrogens.RESULTS:
Some beneficial effects against autoimmune processes seem to be allowed by vitamin D acting in synergy with estrogens. This observation suggests that possible differences of vitamin D effects depend on the context in which this hormone is active.CONCLUSION:
Rather sex-related differences of "absolute" vitamin D levels, the role of gender-dependent factors affecting vitamin D action seems to be critical. Gender and sexual hormones could be included as variables when evaluating the potential power of vitamin D receptor agonists as novel pharmacological tools to approach autoimmune diseases.PMID: 28000549
Publisher wants $95 for the PDF -the most costly I can recall
Women resist infections better, but have more autoimmune diseases – Vitamin D- Dec 2016Printer Friendly Follow this page for updates5091 visitors, last modified 22 Dec, 2016, This page is in the following categories (# of items in each category)