Vitamin D reduced so low that Victorian age diseases are returning

400 IU of Vitamin D used to be enough extra so as to prevent Rickets
Vitamin D levels have gotten so low that 400 IU is rarely enough.

See also VitaminDWiki

• Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019
• Category Rickets contains 127 items
• Why are so many Victorian killer illnesses making a comeback - Nov 2012
• Dickensian diseases are returning – rickets, gout, whooping cough, TB, etc. (low vitamin D) 2018
• Overview of Rickets and Vitamin D
• Turkey gave 400 IU vitamin D to all infants and reduced Rickets by 60X - 2011
• Overview Tuberculosis and Vitamin D
• Category Calcitriol contains 62 items
• Vitamin D Receptor contains 530 items and many ways to compensate for a poor VDR
• Resveratol helps vitamin D bind to cells
• Herpes (Cytomegalovirus) downregulates the vitamin D receptor by 8X – Jan 2017
• Common Vitamin D gene variants and resulting diseases – Jan 2013
• Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
• Omega 3 increases vitamin D in the blood – many studies
• Overview Kidney and vitamin D
• Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018

Genetics category listing contains the following

343 articles in the Genetics category

see also

• Vitamin D Receptor has 530 items
• Vitamin D Binding Protein = GC has 178 items
• CYP27B1 has 63 items
• CYP24A1 in title of 39+ items
• CYP2R1 25+ items
• Calcidiol has 48 items
• Calcitriol has 62 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
      especially if it is one of 51+ diseases related to Vitamin D Receptor
  2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
  3) DNA and VDR tests - 100 to 200 dollars $100 to $250
  4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
     Genes are good, have enough Magnesium, etc.
  5) Back Pain
     probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
  • The founder of VitaminDWiki took action with clues #3&5

Many reasons why vitamin D deficiency has become epidemic includes the following

23 of the 40 reasons for Vitamin D deficiency are new

People have gotten far less Vitamin D from the SUN in the past 40 years

1. Air conditioning - to avoid the hot sun
   air conditioning in home, auto/bus/train, and workplace CLICK HERE
   Air Conditioning probably has decreased vitamin D
   Hypothesis – Air conditioning disease is the result of less vitamin D – China March 2011
2. Increased use of multi-media indoors - TV, DVD, video games, and internet access
   Teens increasingly indoors - especially if have dark skin
   Vitamin D is essential to the modern indoor lifestyle
   Problems of increased TV watching by toddlers – May 2010
   Analysis of the time people spend outdoors – Dec 2010
3. More indoor jobs - more office workers, fewer farmers
   Jobs in cities around the world: 30% in 1950, 70% in 2050
   4X more suburban UV than urban UV – Nov 2010
   Urban residents had 2X less vitamin D – 2008
4. More people living in cities - where there is less UV and they have less opportunity to be outdoors
   Air pollution reduces UV and thus vitamin D
   UVB which produces vitamin D does not reflect off of buildings very well *
5. Want whiter skin especially women
   Here and Here (Helen of Troy) and Being Fair-Skinned in Today's World
   Suntan: Popularity is fading
   Perhaps not burn from the sun if have enough vitamin D
6. Fear skin cancer -
   Overview Suntans and melanoma  Tanning from Wikipedia
   Actually you can get enough vitamin D without getting much of a tan, much less get skin cancer
   Melanoma probability increased 2X if have 5 or more sunburns (Not necessarily at the same location as the burn)
   Most sunscreens increase the growth of skin cancer
   Actually you get 1000X more cancer by not having the vitamin D *
   Most sunscreens increase skin cancer - May 2010
   
   Additional reasons for less vitamin D in past 40 years (beyond lack of sun)
7. Less cholesterol - which the skin needs to produce vitamin D
   Overview of Cholesterol and Vitamin D
   Less cholesterol in diet resulted in less vitamin D in blood (in mice) – Feb 2016
8. More Obesity
   Obese people need more vitamin D PDF file - 2000
   Map of BMI increase - Feb 2011 with many links
   Obese people spend less time in the sun
   Livers of those who are Obese do not function as well, and so do not provide as much vitamin D
9. More soft drinks and fructose - uses up Calcium which uses up vitamin D
   surfers in Hawaii (PDF), who drank a large amount of cola soft drink, had low levels of vitamin D
   Too much fructose reduced both serum and active vitamin D in rats – April 2013
   HFCS consumes Magnesium needed by Vitamin D
     note: Fructose also reduces active vitamin D actually getting to cells - not seen by blood tests
10. Increased consumption of Ultra-processed foods
    Ultra-processed food consumption: 2X increased risk of vitamin D deficiency – Dec 2023
11. Meat from factory farms - has far less vitamin D than from free-range farms
    eggs, chickens, sheep, pigs (500 IU/teaspoon of lard), farmed salmon has 4X less vitamin D than wild salmon
    Wild game, which has been outdoors all of the time, has much more vitamin D - especially in the organ meats
12. Eating less fatty meat and eggs in an attempt to reduce cholesterol. fatty meat was discovered to have a liver-activated form of vitamin D in 2014
    Note: Meat eaters haave 8 ng higher vitamin D levels than vegetarians
13. Drinking low-fat milk which provides only 40% of the vitamin D to the blood compared to whole milk
    6X reduction in consumption of whole milk (1970 ==> 2010), thus 100 IU/glass ==> 40 IU/glass for most people
    Reminder: Most Vitamin D is fat soluble, less fat ==> less vitamin D
14. More drugs which consume or block vitamin D
    Antiseizure, Prednisone, AIDS drugs, Orlistat, Questran, Dilatin, Phenobarbital, Rifampin, Steroids, Calcium channel blockers
    Cholestyramine, Mineral Oil, , St Johns Wort
15. More use of polyunsaturated fats decreased bio-availability of vitamin D
16. More windows: UVA from windows appears to destroy vitamin D (produced by UVB which is blocked by windows)
    More wall space devoted to windows in homes, offices, and public buildings
17. Increased salt consumption which decreases essential Vitamin D cofactors: Magnesium and Calcium
18. Fluoridated water decreases Magnesium essential for use of vitamin D - Hypothesis?
19. Strong magnetic fields reduce vitamin D levels Perhaps from MRI
20. PCBs increase the chance of deficiency by 3%
21. Plastics in pregnant women increased risk of deficiency by 22%
22. Roundup (glyphosate) decreases vitamin D
23. Flame Retardants also retard active vitamin D
    Flame Retardants were added to US clothing, mattresses, and cushions by 1980
    Doubt that flame retardants are used in developing countries
    Reasons for low vitamin D levels which go back more than 40 years
    
24. Less liver eaten - which used to have very large amounts of vitamin D
    A way to get 40X more vitamin D from beef liver back were it used to be
    Iron deficiency is a cause of Vitamin D deficiency
25. Less Magnesium in foods and drink - Magnesium is needed to utilize vitamin D (as well as build bones)
    Magnesium and vitamin D
    Magnesium deficiency epidemic is similar to the Vitamin D epidemic
    Reasons for lower Mg:
       Use of artificial fertilizers rarely restore Magnesium
           Refined grains and refined sugar have very little Magnesium
       Softened water/bottled water usually have all of the Magnesium removed
       Floridation of water blocks Magnesium
26. More seniors
    seniors get 4X less vitamin D from the sun than youths (less Cholesterol in skin) *
    more people are now living >50 years
    Seniors tend to be outdoors less+In vicious circle: low D makes for lower D
    Also: seniors appear to not activate vitamin D as well (in liver, kidney, skin, etc)
    More cataract surgery ==> avoid bright light
27. Excessive clothing (burka, nun habit, . . .)
    especially if also living far from equator or avoiding the hot sun
28. Have a condition which Consumes vitamin D
    Chemotherapy - (be careful, adding vitamin D increases the impact of some Chemo)
    MS prevented AND treated by vitamin D, a mountain of evidence
29. Have a condition which Prevents Adsorption in the gut
    Bariatric Surgery, Colon Cancer, IBD UC and CD, Crohn's
    Gluten Intolerance, Celiac Disease, Cystic Fibrosis
    Fat malabsorption syndromes from 1985 PDF file
    (Supplement options if have gut problem: Option 1 - Option 2)
30. Have a condition which Prevents Conversion to active vitamin D
    Kidney   vicious cycle
    HIV both prevents conversion and consumes vitamin D
31. Have 1 or more of 6 genes which restrict how much vitamin D gets to cells
    Restrict how much Vitamin D is semi-activated by liver or tissues
    Restict how much semi-activated Vitamin D is carried to kidneys for full activation - not seen by blood test
    Restrict how much Vitamin D is activated by kidneys or tissues - not seen by blood test
    Destroy Vitamin D before it can be used - not seen by blood test
    Restrict activated vitamin D from actually getting into cells - Vitamin D Receptor - not seen by blood test
32. Have a condition which requires more vitamin D - or time in the sun
    Pregnancy Not just bone. Need lots of vitamin D - Before , During, and After
    Dark Skinned and living far from equator or avoiding the hot sun
    Surgery and trauma many files
33. Lactose Intolerance or Vegan – and thus not get vitamin D from milk in US and a few other countries
    also reduces Calcium intake, needed to build bones, prevent Myopia, prevent cardiovascular disease
34. Health reasons to avoid sun (other than skin cancer) burn easily - redhead, etc - there are alternatives
    If avoiding sun you need to supplement with vitamin D – April 2011
35. Work long hours or night shift  Long hours reduced vitamin D by 8% – April 2011
36. Live far from equator even more of a problem if the region is also cloudy (Washington State, Scotland)
    10X more SAD in Seattle than Miami
37. DDT and some other pesticides in our bodies reduce the vitamin D perhaps 3 ng
38. Smoking reduces Calcium, which reduces vitamin D
39. Winter births - 11% more likely for adult to be deficient
    Need to take more vitamin D as an adult if born in winter
40. Myths about vitamin D caused people and researchers to not consider useful amounts
    Myth You can easily take a toxic amount of vitamin D - started in the 1950's by a wrong diagnosis -scared off research and use for 50 years
    Myth Spend 10-15 minutes in the sun three times a week and your vitamin D will be fine. (This myth started out as a hypothesis)
    Myth Eat fish three times a week and your vitamin D will be adequate
    Myth Can get all of your vitamin D needs from food
    Myth Drink a cup of milk every day and your vitamin D will be okay
    Myth A daily multivitamin will meet your vitamin D needs
    Myth You do not develop vitamin D deficiency if you live in a warm, sunny place
    Myth Eating a healthy diet will take care of your vitamin D needs as well
    Myth More Kidney stones if take more vitamin D
    Myth Need lots of Calcium while getting lots of vitamin D ( just the opposite actually)
    Myth No tan is a safe tan (skin cancer can happen in just a few minutes)
    Myth If I sunburn easily I need to stay out of the sum ( No, being sunburned easily is often a sign of being very vitamin D deficient)
    Myth Should reduce cholesterol ( no, actually should increase cholesterol - to produce vitamin D)
    Myth Sunlight alone causes skin cancer (so why does melanoma often occur where the sun does not shine)
    Myth Can get enough vitamin D from the sun to last you thru the winter
    Myth Can get enough vitamin D even if wearing lots of sunscreen
    Myth You can be allergic to vitamin D (allergic reaction is often an indication of low Magnesium)
    Myth Vitamin D2 is almost as good as vitamin D3 (several studies have shown that vitamin D2 DECREASES serum levels of D3)
    See also Vitamin D - Facts and Myths

Risk Factors for Vitamin D Deficiency: has the following charts

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See also web

Hypovitaminosis D and severe hypocalcaemia: the rebirth of an old disease.
BMJ Case Rep. 2013 May 31;2013. pii: bcr2012007406. doi: 10.1136/bcr-2012-007406.
Pedrosa C, Ferraria N, Limbert C, Lopes L.
Pediatric Endocrinology Unit, Hospital de Dona Estefânia, Lisbon, Portugal.

Vitamin D deficiency, once thought to be eradicated, is becoming a frequent occurence in children, caused mainly by dietary insufficiency. The classical manifestation is rickets, but in infants severe hypocalcaemia may present as stridor, tetany, seizures or, rarely, heart disease. Here, we describe four infants who presented with complications of severe hypocalcaemia secondary to nutritional vitamin D deficiency. (1) Female, 4 months old, several spasms. (2) Male, 8 days old, generalised tonic-clonic seizure. (3) Male, 9 months old, tetany. (4) Male, 4 months old, cardiogenic shock.
The cases highlight the importance of child vitamin D supplementation from birth and throughout childhood.
We also note that the vitamin D state should be evaluated by the 25(OH)-D value and not the 1,25(OH)2-D.

PMID: 23729699

Short url = http://is.gd/VitDReductions