Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019

Vitamin D fails to prevent type 2 diabetes in large study

The actual study $40 million

Note: Diabetes and pre-diabetes are associated with poor guts

Since the start of this trial (2013) there have been many proven ways to deal with the restrictions of a poor gut
1) Use the same total amount of Vitamin D, but less frequently - the higher gradient gets thru better
2) Use more vitamin D daily
3) Use a probiotic to deal with the gut problem
4) Use a gut-friendly form of Vitamin D - there are more than a dozen types
5) Increase the response to Vitamin D by using Omega-3 and/or Magnesium
Avoid the poor gut
6) Use an injection
7) Use UV or sun
8) Use topical Vitamin D

The current failed trial was probably unaware of any of the above proven solutions
4,000 IU orally daily, no probiotic, no Magnesium, no Omega-3

Note: The pre-diabetic subgroup which started with < 12 ng of Vitamin D were 62% less likely to get diabetes

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See also VitaminDWiki

Non daily

• Prediabetes both prevented and treated by monthly Vitamin D, etc.
• Insulin resistance helped with 50000 IU of vitamin D weekly – Feb 2013
• Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
• Better than Daily category listing has 33 items along with related searches

Probiotic

• Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018

Not oral

• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
• Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017

Omega-3, Mg, etc

• Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
• Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body has a section on poor digestion
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio	Form	Speed	Duration
10	Injection ($$$) or Calcidiol or Calcitriol	D - Slow C -Fast	Long
10	Sun/UVB	Slow	Long
10	Topical (skin patch/cream, vagina)	Slow Fast nano	Normal
9	Nanoemulsion -mucosal perhaps activates VDR	Fast	Normal
9?	Inhaled (future)	Fast	Normal
8	Bio-D-Mulsion Forte	Normal	Normal
6	Water soluble (Bio-Tech)	Normal	Normal
4	Sublingual/spray (some goes into gut)	Fast	Normal
3	Coconut oil based	Slow	Normal
2	Food (salmon etc.)	Slow	Normal
2	Olive oil based (majority)	Slow	Normal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

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Titles of some of the web reports of this study

NIH-Funded Trial Finds Vitamin D Does Not Prevent Type 2 Diabetes In People At High Risk
Vitamin D3 Supplementation Fails to Significantly Lower Diabetes Risk in Patients with Pre-diabetes
D2d — No Defense against Diabetes
NIH-funded trial finds vitamin D does not prevent type 2 diabetes in people at high risk
D2d: Vitamin D Doesn't Stop Diabetes in Those With Prediabetes
Maine Researcher: ‘Excess Enthusiasm’ For Vitamin D Tamped Down By New Study
Vitamin D Supplements Don't Lower Type 2 Diabetes Risk, Study Suggests
Vitamin D Doesn't Halts The Progression Of Type 2 Diabetes In Patients With Prediabetes
Vitamin D Supplements Do Not Reduce Type 2 Diabetes Risk Significantly
Vitamin D Supplementation Did Not Prevent Type 2 Diabetes in Large Trial
Vitamin D does not prevent type 2 diabetes in people at high risk