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Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014

Vitamin D Status, Receptor Gene Polymorphisms, and Supplementation on Tuberculosis:
A Systematic Review of Case-Control Studies and Randomized Controlled Trials

Journal of Clinical & Translational Endocrinology, DOI: http://dx.doi.org/10.1016/j.jcte.2014.08.001
Nilay Sutariaemail, Ching-Ti Liuemail, Tai C. Chenemail
Received: May 23, 2014; Received in revised form: July 25, 2014; Accepted: August 7, 2014; Published Online: August 15, 2014

Highlights:

•Lower serum 25-hydroxyvitamin D increases susceptibility to tuberculosis.
•BsmI and FokI VDR gene polymorphisms may confer increased risk of acquiring tuberculosis.
•Vitamin D supplementation reduces tuberculosis incidence and increases recovery from tuberculosis.

Objective
To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB).

Methods
We conducted a systematic review of published studies pertaining to case-control and randomized-control trials from 2002 to 2014 using the PubMed database.

Results and conclusion:
Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.

PDF is attached at the bottom of this page

ALL random controlled trial showed reduction of TB when Vitamin D was added
unless there was a very long time between doses (5 months) or very small doses of vitamin D were used (800 IU/day)

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Overview Tuberculosis and Vitamin D
All items in category TB 125 items
All items in category Vitamin D Binding Protein 178 items
All items in category Genetics and Vitamin D 343 items

Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014

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- Health problems that run in families are often associated with low vitamin D Tuberculosis risk decreased by 6 percent for each 1 ng increase in Vitamin D – Oct 2014 Tuberculosis is controlled by Interleukin-32 when it has enough Vitamin D – patent applied for – Aug 2014

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Tuberculosis 109 Genetics 336 Vit D Binding Protein 174

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