Pigment genes not skin pigmentation affect UVB-induced vitamin D
Photochemical & Photobiological Sciences, DOI:10.1039/C8PP00320C
Pameli Datta, Peter Alshede Philipsen, Peter Olsen, Bibi Petersen, Jeppe Dyrberg Andersen, Niels Morling and Hans Christian Wulf
Items in both categories Dark Skin and UV are listed here:
Items in both categories Seniors and UV are listed here:
- Seniors get about 4X less vitamin D from the sun or UVB
- Response to UV varies more with pigment genes and age than skin color – Jan 2019
- Risks and benefits of UV radiation in older people: More of a friend than a foe - May 2015
- Weekly UV almost doubled elderly Vitamin D levels – Dec 2010
- Recommendations to elderly- avoid UV but take vitamin D – May 2010
UV weekly dose was not constant. increased during the winter trial – Clipped from PDF
“All participants received identical UVB doses gradually increasing over nine weeks from October to December. UVB treatments, each of 0.94 kJ m−2 (2 SEDs), were administered bi-weekly during the first two weeks. In the following five weeks, the frequency was increased to three sessions per week. During the last two weeks, 3 weekly sessions, each of 1.4 kJ m−2 (3 SEDs), were administered. The total UVB dose during the nine weeks was 26 kJ m−2 (56 SEDs)"
This small study of 40 people appears to ignore the differences due to things such sa
Weight,
Low Magnesium,
Low Omega-3%%%Vitamin D genes
Smoking
Low Cholesterol
Anemia
DDT
Poor Liver
Excessive Vitamin A
- Reasons for low response to vitamin D ~30 reasons for poor response to Vitamin D (or probably UV)
- 10 health problems associated with Dark Skin (low vitamin D)
- Half of US high school students will have dark skins by 2025
Overview Dark Skin and Vitamin D contains the following summary
FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D
African American Health Disparities are associated with low Vitamin D - Grant Feb 2021
Low Vitamin D increases health problems - independent of skin color
Blacks die more often than whites of many diseases (they have less vitamin D) – 2012 contains the following summary
Cancer Facts & Figures for African Americans Cancer.org
- “African Americans have the highest death rate and shortest survival of any racial and ethnic group in the US for most cancers”
- Has a huge number of tables and charts, Note: Vitamin D is not mentioned
Leading Causes of Death as of March 2018
| All Ages Death rate | Black | White | Ratio |
| Heart diseases | 217 | 171 | 1.27 |
| Cancer | 199 | 170 | 1.17 |
| Cerebrovascular diseases | 51 | 36 | 1.4 |
| Diabetes | 40 | 19 | 2.0 |
Rates per 100,000 Age adjusted Non-Hispanic
The more the African Ancestry, the lower the vitamin D level – July 2010
Download the PDF from Sci-Hub via VitaminDWiki
Vitamin D levels increased during the trial
Skin pigmentation is believed to contribute to the generally low serum 25-hydroxyvitamin D (25(OH)D) concentrations observed in darker-skinned persons. The influence of measured skin pigmentation on UVB-induced 25(OH)D increase was investigated together with 9 demographic and 13 genetic parameters (pigment SNPs).
Forty participants representing a wide range in measured skin pigmentation were exposed to identical UVB doses on identical body areas over nine weeks with weekly measurements of serum 25(OH)D.
This study took place in Denmark during winter, a period with negligible ambient UVB, so variation in 25(OH)D synthesis was not influenced by latitude, season, sun and clothing habits.
The increase in 25(OH)D concentration displayed considerable variation (range: 2.9 to 139 nmol L-1).
Constitutive and facultative skin pigmentation exerted separate influence on the variation of the UVB-induced linear 25(OH)D increase. However, this influence was statistically non-significant in the presence of separate significant pigment SNPs.
The variation in the 25(OH)D increase in the combined linear model was not explained by measured skin pigmentation but by sex, height, age and seven SNPs located in the ASIP, MTAP, MIR196A29 and Solute Carrier Family genes.
This linear model including individual intercepts and the 10 parameters influencing the slope explained 77.4% of the variation.
This study confirmed the influence of sex, age and height on 25(OH)D increase and found that pigment genes provided a better relation to UVB-induced 25(OH)D increase compared to the actual measured skin pigmentation. Therefore, only investigating skin pigmentation obscure other causal parameters for low 25(OH)D.
New title for this page March 2019. caused the visitor count to reset.There have actually been
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