Metabolic Syndrome prevented by Vitamin D, Phytochemicals and improved gut bacteria - Feb 2023

---

Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D

Review Int J Mol Sci . 2023 Jan 30;24(3):2627. doi: 10.3390/ijms24032627.
Kazuki Santa 1, Yoshio Kumazawa 2 3, Isao Nagaoka 3 4

---

In recent years, attention has focused on the roles of phytochemicals in fruits and vegetables in maintaining and improving the intestinal environment and preventing metabolic syndrome. A high-fat and high-sugar diet, lack of exercise, and excess energy accumulation in the body can cause metabolic syndrome and induce obesity, diabetes, and disorders of the circulatory system and liver. Therefore, the prevention of metabolic syndrome is important. The current review shows that the simultaneous intake of phytochemicals contained in citruses and grapes together with vitamin D improves the state of gut microbiota and immunity, preventing metabolic syndrome and related diseases.

Phytochemicals contained in

• citruses include polyphenols such as hesperidin, rutin, and naringin; those in
• grapes include quercetin, procyanidin, and oleanolic acid.

The intake of these phytochemicals and vitamin D, along with prebiotics and probiotics, nurture good gut microbiota. In general,

Firmicutes are obese-prone gut microbiota and Bacteroidetes are lean-prone gut microbiota; good gut microbiota nurture regulatory T cells, which suppress inflammatory responses and upregulate immunity. Maintaining good gut microbiota suppresses TNF-α, an inflammatory cytokine that is also considered to be a pathogenic contributor adipokine, and prevents chronic inflammation, thereby helping to prevent metabolic syndrome. Maintaining good gut microbiota also enhances adiponectin, a protector adipokine that prevents metabolic syndrome. For the prevention of metabolic syndrome and the reduction of various disease risks, the intake of phytochemicals and vitamin D will be important for human health in the future.
 Download the PDF from VitaminDWiki

---

VitaminDwiki – Metabolic Syndrome contains

106 items

See also

• Overview Metabolic Syndrome and vitamin D
• Overview Diabetes and vitamin D
• Overview Obesity and Vitamin D
• Diabetes, Metabolic Syndrome and Magnesium - many studies
• Arteries and Atherosclerosis and Vitamin D - many studies
• Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
• Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
• Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
• Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
• Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
• Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
• Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
• Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
• Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
• Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
  

See also

• Gut Microbiota: improved by Vitamin D – narrative review – July 2021
• Gut microbiome altered by many nutrients – such as Vitamin D – Jan 2020
• Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018

---

Metabolic Syndrome Associations with other categories

 Obesity 19;  Diabetes 15;  Cardiovascular 12;  Magnesium 8;  Seniors 8;  Women 5; 5;  Hypertension 5;  Intervention 5;  Omega-3 4;  Youth 4;  Meta-analysis 4

---

VitaminDwiki – Microbiome contains

Some of the 41 Microbiome articles

• Nutrients, Microbiome, and Chronic Diseases - April 2023
• Fecal transplants - many studies
• Healthy microbiota might reduce COVID-19 – several studies
• Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020
• Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020
• Parkinson's Disease and gut microbiome - several studies
• Vitamin D levels change Gut Microbiota – 25 study review Sept 2021
• Gut Microbiota: improved by Vitamin D – narrative review – July 2021
• Gut microbiome massively changed by weekly vitamin D – July 2015
• Also: Google Scholar on Microbiome includes:The cancer microbiome - June 2019, The Healthy Microbiome—What Is the Definition of a Healthy Gut Microbiome? - Jan 2021, The gut microbiome in neurological disorders - Feb 2020, Understanding the role of the gut microbiome in gastrointestinal cancer: A review -Jan 2023, The human microbiome and COVID-19: A systematic review - June 2021, *Interaction between drugs and the gut microbiome - July 2020

---

VitaminDWiki - Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies