Association between magnesium and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency
European Journal of Nutrition Volume 64, article number 48, (2025) https://doi.org/10.1007/s00394-024-03559-9
Armin Zittermann, Sieglinde Zelzer, Markus Herrmann, Marcus Kleber, Winfried Maerz & Sefan Pilz
Purpose
It has been assumed that magnesium (Mg) status may interact with vitamin D status. We therefore aimed at investigating the association between Mg and vitamin D status in a large cohort of adult individuals with a high prevalence of deficient/insufficient vitamin D and Mg status.
Methods
We used data from the Ludwigshafen Risk and Cardiovascular Health Study (n = 2,286) to analyze differences according to serum Mg status in circulating 25-hydroxyvitamin D [25(OH)D] (primary endpoint), 24,25-dihydroxyvitamin D3 [24,25(OH)2D3], vitamin D metabolite ratio and calcitriol, and odds ratios for deficient or insufficient 25(OH)D (secondary endpoints). We performed unadjusted and risk score (RS) adjusted and matched analyses.
Results
Of the study cohort (average age > 60 years), one third was 25(OH)D deficient (< 12 ng/mL), one third 25(OH)D insufficient (12 to < 20 ng/mL), about 10% Mg deficient (< 0.75 mmol/L) and additional 40% potentially Mg deficient (0.75 to 0.85 mmol/L).
In adjusted/matched analyses, 25(OH)D was only non-significantly lower in Mg deficient or insufficient groups versus their respective control group (P > 0.05).
Only the RS-adjusted, but not the RS-matched odds ratio of 25(OH)D deficiency was significantly lower for the group with adequate versus deficient/potentially deficient Mg status (0.83; 95%CI: 0.69–0.99), and only the RS-matched, but not the RS-adjusted odds ratio of 25(OH)D insufficiency was significantly lower for non-deficient versus deficient Mg status (0.69; 95%CI: 0.48–0.99). Other adjusted or matched secondary endpoints did not differ significantly between subgroups of Mg status.
Conclusions
Our data indicate only little effect between Mg and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency.
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VitaminDWiki – Magnesium and Vitamin D contains
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Magnesium and Vitamin D
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- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
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12+ VitaminDWiki Magnesium pages have MANY STUDIES in the title
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Associations between Magnesium and other categories
Omega-3 33, Diabetes 27, Vitamin K 27, Calcium 26, Virus 25, Zinc 24, Cardiovascular 17, Bone - Health 15, Vitamin B12 15, Iron 14, Depression 14, Supplement 12, Vitamin C 11, Obesity 11, Hypertension 11, Headache 10, Boron 10, Pregnancy 10, Metabolic Syndrome 9, Intervention 9, Mortality and D 8, Iodine 8, Seniors 8, Deficiency of Vitamin D 8, Books, videos on Vitamin D 7, Pain - chronic 7, Resveratrol 7, Interactions with Vitamin D 6, Vitamin D and Vitamin A 6, Cognitive 6, Falls and Fractures 5, Trauma and surgery 5, Kidney 5, Women 5, Osteoporosis 4, Breathing 4, Infant-Child 4, ADHD 4, Cancer - Breast 4, Cancer - Colon 4, Predict Vitamin D 4, Associations 4, Off Topic 4, Curcumin 4 (Nov 2023)
VitaminDWiki – Overview Magnesium and vitamin D has a venn diagram
| Magnesium | not Magnesium | |
| Vitamin D | Magnesium or Vitamin D Aging, Amyotrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder, Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis, Peripheral vascular disease; Pregnancy-related problems, Rheumatoid Arthritis, Sports-related problems, | Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports |
| Not Vitamin D | Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity, Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapse, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence | Neither ALL OTHER DISEASES |
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