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Heart Failure and Vitamin D meta-analyses - many studies


CVD mortality 1.5X higher if <20 ng of vitamin D (China) - meta-analysis Aug 2019

Low serum vitamin D levels increase the mortality of cardiovascular disease in older adults: A dose-response meta-analysis of prospective studies
Medicine (Baltimore). 2019 Aug;98(34):e16733. doi: 10.1097/MD.0000000000016733.
Yang J1, Ou-Yang J2, Huang J3.
1 Department of Medical College, Tianmen Vocational College.
2 Department of Laboratory.
3 Department of Neurology, Tianmen First People's Hospital, Tianmen, Hubei Province, China.
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Lower circulating vitamin D is common in older adults and may be a potential reversible risk factor for cardiovascular disease (CVD) in older adults, however, presented controversial results.Database was searched update to February 2018. Key data were extracted from eligible studies. Dose-response meta-analysis were conducted for synthesizing data from eligible studies.A total of 13 eligible studies involving 21,079 participants were included in this meta-analysis.
Person with lower 25-hydroxyvitamin D status (25 (OH)D level <50 nmol/L) appeared to have higher mortality of CVD in older adults (RR = 1.54, 95% CI 1.24-1.91).
Furthermore, a significantly higher mortality of CVD in older adults was observed for the

  • deficient (<25 nmol/L; RR = 1.47, 95% CI 1.15-1.81) and
  • nsufficient (25-50 nmol/L; RR = 1.16, 95% CI 1.04-1.27) categories of 25 (OH)D,

compared to the reference category of >75 nmol/L.
Additionally, decrease of 10 nmol/L 25-hydroxyvitamin D was associated with a 7% incremental in the risk of CVD mortality in older adults.Considering these promising results, circulating vitamin D is associated with CVD mortality increment in older adults.


Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – meta-analysis Nov 2019

Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019 Iran


Vitamin D is as good as conventional drugs at treating Chronic Heart Failure Meta-analysis Jan 2016

Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta-analysis of Randomized Controlled Trials
Clin Cardiol. 2016 Jan;39(1):56-61. doi: 10.1002/clc.22473. Epub 2015 Sep 28.
Jiang WL1, Gu HB2, Zhang YF1, Xia QQ1, Qi J3, Chen JC2.

BACKGROUND: In recent years, there has been growing evidence that vitamin D deficiency is associated with the development and progression of chronic heart failure (CHF).

HYPOTHESIS: Additional supplementation of vitamin D may have protective effects in patients with CHF.

METHODS:
We searched PubMed, Embase, and Cochrane databases through June 2015 and included 7 randomized controlled trials that investigated the effects of vitamin D on cardiovascular outcomes in patients with CHF. Then, we performed a meta-analysis of clinical trials to confirm whether vitamin D supplementation is beneficial in CHF patients. The weighted mean difference (WMD) and 95% confidence interval (CI) were calculated using fixed- or random-effects models.

RESULTS:
Our pooled results indicated that additional supplementation of vitamin D was not superior to conventional treatment in terms of left ventricular ejection fraction, N-terminal pro-B-type natriuretic peptide, and 6-minute walk distance. Moreover, vitamin D supplementation was associated with significant decreases in the levels of tumor necrosis factor-α (WMD: -2.42 pg/mL, 95% CI: -4.26 to -0.57, P < 0.05), C-reactive protein (WMD: -0.72 mg/L, 95% CI: -1.42 to -0.02, P < 0.05), and parathyroid hormone (WMD: -13.44 pg/mL, 95% CI: -21.22 to -5.67, P < 0.05).

CONCLUSIONS: Vitamin D supplementation may decrease serum levels of parathyroid hormone and inflammatory mediators in CHF patients, whereas it has no beneficial effects on improvement of left ventricular function and exercise tolerance.
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Vitamin D helps remodeling after HF - meta-analysis Aug 2018

Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.
BMJ Open. 2018 Aug 30;8(8):e020545. doi: 10.1136/bmjopen-2017-020545.
Zhao JD1, Jia JJ1, Dong PS1, Zhao D1, Yang XM1, Li DL1, Zhang HF1.

OBJECTIVES: The level of vitamin D is considered to be associated with the development and progression of heart failure (HF). However, it is still unclear whether supplementation of vitamin D could improve ventricular remodelling in patients with HF. This study aimed to systematically evaluate the influence and safety of additional vitamin D supplementation on ventricular remodelling in patients with HF.

DESIGN: This study is a meta-analysis of randomised controlled trials (RCTs).

SETTING: The PubMed, EMBASE, CNKI, Cochrane library, Web of Science databases and grey literature were searched for RCTs regarding the effect of vitamin D on ventricular remodelling in patients with HF (from database creation to October 2017). RevMan V.5.3 software was employed for data analysis.

PARTICIPANTS: Seven RCTs with a total of 465 patients, including 235 cases in the vitamin D group and 230 cases in the control group, were included.

PRIMARY AND SECONDARY OUTCOME MEASURES: Left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF) and the incidence of adverse reactions.

RESULTS:
Compared with the control group, a decrease in the LVEDD (mean difference (MD)=-2.31 mm, 95% CI -4.15 to -0.47, p=0.01) and an increase in the LVEF (MD=4.18%, 95% CI 0.36 to 7.99, p=0.03) were observed in the vitamin D group. Subgroup analysis also revealed a reduced LVEDD in adults (>18 years) and adolescents (<18 years) of the vitamin D group relative to that in those of the control group. High-dose vitamin D (>4000 IU/day) was more effective at reducing the LVEDD than low-dose vitamin D (<4000 IU/day). Moreover, vitamin D supplementation was more effective at reducing the LVEDD and increasing the LVEF in patients with reduced ejection fraction than in patients without reduced ejection fraction.

CONCLUSION: Vitamin D supplementation inhibits ventricular remodelling and improves cardiac function in patients with HF.

TRIAL REGISTRATION NUMBER: CRD42017073893.
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ID Name Comment Uploaded Size Downloads
12549 CVD death.jpg admin 27 Aug, 2019 91.16 Kb 785
12540 CVD Meta 2019.jpg admin 24 Aug, 2019 38.81 Kb 1047
12539 CVD Meta 2019.pdf admin 24 Aug, 2019 576.46 Kb 502
11203 CoQ10 treats heart failure - Review July 2018.pdf admin 14 Jan, 2019 516.10 Kb 601
11202 Chronic Heart Failure 2016.pdf admin 14 Jan, 2019 1.16 Mb 578