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Half as much blistering diseases (bullous) in portions of Chile with lots of sunshine – Feb 2025


Inverse association between regional solar radiation and hospital discharges due to bullous diseases in Chile: An ecological study

JAAD International - Letter to the editor
Ignacio Alarcón, BSca ∙ Javier Arellano, MD, MCE, MScb,c javierarlo at uchile.cl

To the Editor: Over the last years, multiple studies have sought to find associations between vitamin D levels and various diseases (eg, inflammatory and autoimmune diseases). Countless functions of vitamin D in immunity, different from the well-known osteometabolic functions, have been described.1,2 For this reason, there has been interest in evaluating the possible association between vitamin D and bullous diseases.
Bullous diseases have a wide range of manifestations and can be categorized according to the level of the skin where the blister occurs, either intraepidermal (pemphigus) or subepidermal (pemphigoid).3 Unlike its clinical and histopathological aspects, there is limited amount of literature regarding their epidemiological characteristics, and studies are generally small with a high risk of bias.
To date, studies have evaluated the possible association between individual vitamin D levels and the incidence of bullous diseases, with heterogeneous results.4 Moreover, studies have included patients from the same geographical location, lacking sufficient heterogeneity of exposure.
In this context, Chile's unique geography, located between latitudes 17° S and 56° S, is highly advantageous as it allows the population to have different levels of solar radiation exposure across various latitudes and regions. This, in turn, suggests different levels of vitamin D in the population, achieving a broad range of exposure heterogeneity. Previous works explore the association between dermatological pathologies and lower levels of vitamin D in Chile, correlated with latitude and exposure to UV radiation.5
We performed an ecological study to evaluate the association between regional solar radiation and hospital discharges due to bullous diseases in Chile between 2001 and 2015. Hospital discharge rates for bullous diseases were calculated per million inhabitants and analyzed concerning annual cumulative solar radiation, finding a statistically significant inverse relationship between these 2 variables.
Regions with higher levels of solar radiation had lower rates of hospital discharges for these conditions. This trend was consistent across different age groups, with a particularly notable effect in the population aged 50 years and older. The regression analysis showed a negative coefficient for annual cumulative solar radiation, indicating that as solar radiation increases, the rate of hospital discharges decreases (P < .05) (Fig 1). This can be observed in colorimetric maps that visually represent the regional variations in these figures (Fig 2).
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VitaminDWiki - 5 studies in both categories Autoimmune and Skin

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VitaminDWiki - Rare skin diseases (autoimmune bullous ) strongly associated with low vitamin D and is increasing – Feb 2015


VitaminDWiki – Noontime sun and D category contains

Noontime sun and D has 331 items

see also
No – 10 minutes per day of sun-UVB is NOT enough
Vitamin D Myths - SUN
Optimize vitamin D from the sun
Overview Suntan, melanoma and vitamin D
Overview UV and vitamin D
50 ng of Vitamin D - 100 hours of noon sunbathing OR 3 dollars of Vit D
3.3 X more likely to be Vitamin D deficient if wear long-sleeves – Oct 2022
Sun and UV
Avoiding the sun may be as bad as smoking - many studies
Vitamin D from the sun without the heat (silver-coated plexiglass)
Opinion: sun better than UV better than vitamin D
Fewer cognitive problems if more sun or Vitamin D
Which Is Worse - Avoiding Sunlight or Vitamin D Deficiency – April 2019
Have We Gotten Sunscreen Totally Wrong - Jan 2019
People who get little noon-day sun must supplement with Vitamin D – systematic review June 2017
The Greatest Public Health Mistake of the 20th Century (sunscreen block Vitamin D) - 2017
Does Less Sun mean More Disease 5 minute video
340,000 US deaths annually due to insufficient sun (some due to low vitamin D) – July 2020
Health benefit of Sunlight is more than Vitamin D in the blood - many studies
5 Amazing Properties of Sunlight You've Never Heard About
Vitamin D and Sun conference – Germany June 2017


15 Benefits of the Sun

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44+ VitaminDWiki pages have LATITUDE in the title

The list is automatically updated

Items found: 44
Title Modified
Vitamin D varies with latitude - map of Chile 02 Dec, 2024
Serotonin related to season, light and perhaps latitude and vitamin D 21 Mar, 2022
2700 IU of vitamin D needed to get above 20 ng if dark-skinned and high latitude – Oct 2021 27 Oct, 2021
Multiple Sclerosis varies with latitude while young – March 2021 12 Mar, 2021
COVID-19 onset strongly associated with latitude in Europe (Vitamin D)– Jan 21, 2021 22 Jan, 2021
European COVID-19 2nd wave start dates were associated with latitude (vitamin D), not temperature – Oct 31, 2020 30 Oct, 2020
COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020 21 Apr, 2020
Multiple Sclerosis incidence is still associated with latitude – Nov 2019 19 Dec, 2019
Bones of white children not helped by 1,000 IU of vitamin D (Northern latitudes) – RCT Sept 2018 05 Nov, 2019
Many diseases increase with latitude (low UV, Vitamin D) 14 May, 2019
Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016 22 Feb, 2019
Multiple Sclerosis incidence varies with latitude (noted in Brazil too) – Nov 2015 08 Dec, 2018
Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017 23 May, 2017
Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 11 Dec, 2016
Headaches vary with latitude and season and perhaps vitamin D as well -May 2010 05 Nov, 2016
Environmental risk factors for MS include latitude and vitamin D – Sept 2012 05 Nov, 2016
Bariatric Surgery problems associated with season, latitude (low Vitamin D) – Dec 2015 25 Oct, 2016
Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016 21 Jun, 2016
MS is related to latitude – conclusion from 321 studies – April 2011 17 Mar, 2016
Why has the MS latitude gradient disappeared – Oct 2011 17 Mar, 2016
Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016 13 Jan, 2016
Multiple Sclerosis web survey: 82 percent take vitamin D (2000-5000 IU), strong association with latitude - Aug 2015 05 Aug, 2015
Headaches related to latitude and season – perhaps vitamin D - May 2010 03 Aug, 2015
Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013 20 Feb, 2015
Dementia risk increases with latitude (less vitamin D) - Feb 2015 20 Feb, 2015
20 cent vitamin D pill similar to 2 hours sunbathing at 60 degree latitude – RCT Aug 2013 16 Mar, 2014
2 cent vitamin D pill similar to 1 hour daily sunbathing at 60 degree latitude – RCT Aug 2013 15 Mar, 2014
Breast Cancer associated with low vitamin D in low latitudes only in white women – Jan 2014 13 Feb, 2014
Perhaps Italians have air conditioning too: lower latitudes have less vitamin D – July 2013 08 Aug, 2013
Air conditioning has not totally canceled the latitude effective in the US yet – July 2013 08 Aug, 2013
Migration to Northern Latitudes enabled by mutation of gene: DHCR7 resulting in more vitamin D – July 2013 11 Jul, 2013
Vitamin D deficiency varies with latitude in Asia, as it does elsewhere – Jan 2013 08 Apr, 2013
Schizophrenia and vitamin D have latitude-related genes – Nov 2010 28 Feb, 2013
Mortality varies with latitude in the UK – Feb 2011 12 Nov, 2012
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
Lack of health insurance varies with latitude - inversely with UV 01 Jan, 2012
Vitamin D levels in first trimester vary with latitude – April 2011 27 Sep, 2011
Hypothesis - 40 ng is enough vitamin D if high latitude or dark skin 02 Jul, 2011
Latitude may not be too associated with vitamin D – Masterjohn Dec 2010 13 Mar, 2011
Vitamin D and latitude Masterjohn - Dec 2010 24 Dec, 2010
Vitamin D not change with latitude unless caucasian - 2009 24 Dec, 2010
Increase in some childhood cancers with latitude – Nov 2010 26 Nov, 2010
MS onset 2 years earlier in northern latitudes – June 2010 20 Aug, 2010
Breast Cancer vs latitude 20 Aug, 2010

VitaminDWiki – Vitamin D Far from Equator category contains:

124 items in category Vitamin D Far from Equator
See also: High Risk
Vitamin D varies with latitude - map of Chile
Many diseases increase with latitude (low UV, Vitamin D)
Russia and Vitamin D - many studies
Iceland and Vitamin D - many studies
After years of adding vitamin D, Finland now has 38 ng levels - March 2022
2400 IU of vitamin D needed to get most Northern adults above 20 ng – June 2020

Attached files

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