Vitamin D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients
Clin Chem Lab Med. 2021 Jan 18. doi: 10.1515/cclm-2020-1567. Online ahead of print.
Laurence Orchard 1, Matthew Baldry 1, Myra Nasim-Mohi 1, Chantelle Monck 2, Kordo Saeed 3 4, Michael P W Grocott 1 4 5, Dushianthan Ahilanandan 1 4 5, University Hospital Southampton Critical Care Team and the REACT COVID Investigators
Note: It appears that Vitamin D levels must be >40 ng to fight COVID-19
Virtually no patient in this study had that level
This UK study compared >20 ng vs <20 ng
The UK still (mistakenly) thinks that vitamin D levels >20 ng fix all health problems
COVID-19 treated by Vitamin D - studies, reports, videos
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Objectives: The pattern of global COVID-19 has caused many to propose a possible link between susceptibility, severity and vitamin-D levels. Vitamin-D has known immune modulatory effects and deficiency has been linked to increased severity of viral infections.
Methods: We evaluated patients admitted with confirmed SARS-COV-2 to our hospital between March-June 2020. Demographics and outcomes were assessed for those admitted to the intensive care unit (ICU) with normal (>50 nmol/L) and low (<50 nmol/L) vitamin-D.
Results: There were 646 SARS-COV-2 PCR positive hospitalisations and 165 (25.5%) had plasma vitamin-D levels. Fifty patients were admitted to ICU. There was no difference in vitamin-D levels of those hospitalised (34, IQR 18.5-66 nmol/L) and those admitted to the ICU (31.5, IQR 21-42 nmol/L). Higher proportion of vitamin-D deficiency (<50 nmol/L) noted in the ICU group (82.0 vs. 65.2%). Among the ICU patients, low vitamin D level (<50 nmol/L) was associated with younger age (57 vs. 67 years, p=0.04) and lower Cycle Threshold (CT) real time polymerase chain reaction values (RT-PCR) (26.96 vs. 33.6, p=0.02) analogous to higher viral loads. However, there were no significant differences in ICU clinical outcomes (invasive and non-invasive mechanical ventilation, acute kidney injury and mechanical ventilation and hospital days) between patients with low and normal vitamin-D levels.
Conclusions: Despite the association of low vitamin-D levels with low CT values, there is no difference in clinical outcomes in this small cohort of critically ill COVID-19 patients. The complex relationship between vitamin-D levels and COVID-19 infection needs further exploration with large scale randomized controlled trials.