96 percent of ear, nose, throat children had less than 30 ng of vitamin D – Jan 2013

Vitamin d deficiency in E.N.T. Patients.

Indian J Otolaryngol Head Neck Surg. 2013 Jan;65(1):57-60. doi: 10.1007/s12070-012-0603-9. Epub 2012 Dec 1.
Taneja MK 1 ijo_editor at rediffmail.com, Taneja V 2.

A prospective study to observe the prevalence of deficiency of vitamin D in out patients of otolaryngology clinic at Indian Institute of ear diseases, Muzaffarnagar. The patients attending outpatient of otolaryngology clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH)D] level in blood. The age, sex, occupation, colour of skin, chief complaints, obesity, provisional diagnosis, and incidence of sun exposure was noted in all cases. A total of 86 patients were examined, maximum patients were in the age group of 7-15 years.
The chief complaints in majority of the patients were sore throat with recurrent upper respiratory tract infection.
Only in three patient's vitamin D level was found to be with in normal limits.
In rest 83 (96.51 %) it was either deficient 57 (66.28 %) or insufficient 21 (24.42 %).
The incidence of vitamin D deficiency is extremely common in Ear Nose Throat disease (E.N.T.) patients.
The results of vitamin supplementation were promising in cases of benign paroxysmal positional vertigo with cervical spondylosis and URTI with asthma, empirical supplementation of vitamin D in all E.N.T. patients not responding to conventional treatment is worth trying. At place of sun screen, use of pomegranates and blueberries may be encouraged to prevent sunburn and eliminate Vitamin D deficiency.

KEYWORDS: B.P.P.V., Bronchial asthma, Cervical spondyliosis, E.N.T, URTI, Vitamin D deficiency
PMID: 24381922

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See also VitaminDWiki

• Middle ear infection (Otitis Media) and Vitamin D – many studies
• Hearing Loss appears to be prevented and treated with vitamin D
• Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012
• Additional 4 ng of vitamin D reduced chance of infection by 7 percent – June 2011
• Ear category listing has 17 items

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References

1. Muhe L, Lulseged S, Mason KE, Simoes EA (1997) Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 349:1801–1804 CrossRef
2. Bikle D (2009) Nonclassic actions of vitamin D. J Clin Endocrinol Metab 94:26–34 CrossRef
3. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G (2007) Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25–D3. J Cyst Fibros 6:403–410 CrossRef
4. Wayse W, Yousafzai A, Mogale K, Filteau S (2004) Association of subclinical dihydroxivitamin vitamin D deficiency with severe acute lower respiratory tract infections in Indian children under 5 years. Eur J Clin Nutr 58:563–567 CrossRef
5. Hughes DA, Norton R (2009) Vitamin D and respiratory health. Clin Exp Immunol 158:20–25 CrossRef
6. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086S
7. Ginde AA, Mansbach JM, Camargo CA Jr (2009) Association between serum 25-hydroxy vitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey. Arch Intern Med 169:384–390 CrossRef
8. Reichel H, Koeffler HP, Bishop JE, Norman AW (1987) 25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J Clin Endocrinol Metab 64:1–9 CrossRef
9. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770–1773 CrossRef
10. Webber G, Heilborn JD, Chamorro Jimenez Cl, Hammarsjo A, Torma H, Stahle M (2005) Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatal 124:1080–1082 CrossRef
11. Gombart AF, Borregaard N, Koeffler HP (2005) Human cathelicidin antimicrobial peptide (CAMP) is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxy vitamin D3. FASEB J 19(9):1067–1077 CrossRef
12. Liu PT, Stenger S, Tang DH, Modlin RL (2007) Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 179:2060–2063
13. Hansdottir S, Monick MM, Hinde SL, Lavan N, Look DC, Hunninghake GW (2008) Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol 181:7090–7099
14. Taneja MK, Vivek Taneja (2012) Role of vitamin D in prevention of deafness. Indian J otology 18(2):55–57 CrossRef
15. Cammargo CA, Rifas-Shiman SL, Liuonjua AA, Burris HH, Kleinman K, Huh SY (2006) Prospective study of maternal intake of vitamin D during pregnancy and risk of wheezing illeness in children at age 2 years. J Allergy Clin Immunol 117:721–722 CrossRef
16. Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S (2007) Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 85:853–859
17. Brookes GB (1985) Vitamin D deficiency and deafness: 1984 update. Am J Otology 6(1):102–107
18. Taneja MK (2012) Role of ENT surgeons in the national program for prevention and control of deafness. Indian J otology 3(18):119–121 CrossRef
19. Brookes GB, Morrrison AW (1981) Vitamin D deficiency and deafness. Br Med J Clin Res Ed 283:273–274 CrossRef
20. Bartley Jim, Reid David, Morton Randall P (2009) Prevalence of vitamin D deficiency among patients attending a general otolaryngology clinic in south auckland. Annals Otology Rhinology Laryngol 118(5):326–328
21. Rockell JEP, Skeaff CM, Williams SM, Green TJ (2006) Serum 25 hydroxyvitamin D concentrations of New Zealanders aged 15 and older. Osteoporos Int 17:1382–1389 CrossRef
22. Linday LA, Shindledecker RD, Dolitsky JN, Chen TC, Holick MF (2008) Plasma 25-Hydroxy vitamin D levels in young children undergoing placement of tympanostomy tubes. Annals Otology Rhinology Laryngol 117(10):740–744