8X higher Osteoporosis risk if high level of vitamin A, vitamin D important too – Feb 2013

Vitamin D insufficiency together with high serum levels of vitamin A increases the risk for osteoporosis in postmenopausal women.

Arch Osteoporos. 2013 Dec;8(1-2):124. Epub 2013 Feb 16.
Mata-Granados JM, Cuenca-Acevedo JR, Luque de Castro MD, Holick MF, Quesada-Gómez JM.
Department of I+D+I, Sanyres Group, Córdoba, Spain.

Postmenopausal women who were vitamin D deficient and had high serum levels of retinol had an eight times higher risk of having osteoporosis.
A high retinol level together with vitamin D deficiency/insufficiency is an additional risk factor for osteoporosis.

PURPOSE: The aim of this study was to evaluate the association between vitamin D deficiency/insufficiency and excess of vitamin A intake as an osteoporosis risk factor in healthy postmenopausal women

DESIGN: The design is a cross-sectional study of 232 healthy postmenopausal women.

METHODS: Bone mass was evaluated by dual energy X-ray absorptiometry. Serum calcium, albumin phosphorus, creatinine, total high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides analyzed by standard methods and retinol and 25-hydroxyvitamin D [25(OH)D] measured by an online solid-phase extraction coupled with high-pressure liquid chromatography-ultraviolet detection.

RESULTS: Prevalence of vitamin D deficiency [25(OH)D < 20 ng/mL] was 70.1 %; 14.3 % had a 25(OH)D < 10 ng/mL, and 23.6 % had insufficiency [25(OH)D 21-29 ng/mL]. Prevalence of high serum levels of retinol (>80 μg/dL) was 36.4 %.
Among subjects with 25(OH)D <20 ng/mL (n = 152), 60.4 % (n = 92) had serum levels of retinol > 80 μg/dL.
Bone density measurements revealed that the risk of osteoporosis was ~8 times higher in women with the highest retinol levels, as compared with women with the lowest retinol levels.
In women with 25(OH)D < 20 ng/mL, the risk for osteoporosis increased substantially in women who had the highest blood levels of retinol compared to the women with lowest retinol levels.

CONCLUSIONS: Higher retinol levels together with vitamin D deficiency could be a significant additional risk factor for osteoporosis, underscoring the need for improved physician and public education regarding optimization of vitamin D status in postmenopausal women and developing policies to avoid high serum levels of vitamin A.

PMID: 23417776

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Comment by VitaminDWiki

Anticipate seeing vitamin A implicated in many future studies

See also VitaminDWiki

• Vitamin A may thwart the ability of vitamin D to reduce risk of osteoporosis – June 2010 previous study by same researchers
• All items in category Vitamin A 69 items
• Vitamin A (Cod Liver Oil) blocks vitamin D – 2008
• Excess vitamin A caused calcification of heart valves in mice – Dec 2012
• Vitamin D protects against lung cancer unless there is excess vitamin A – July 2012
• Vitamin D needs some vitamin A, but not too much