600,000 IU of vitamin D – 42 ng at 3 months for 1 inj, 3 inj, oral monthly, oral weekly - Oct 2017

600,000 IU ==> 42 ng/ml in 3 months

• Injection used if unsure if person will take follow-on doses, or if poor gut and a gut-friendly form is not available
• Quick oral loading is needed if vitamin D levels must be restored quickly Faster than 1 month)
• Oral can be a single time or spread over a week - if there is no emergency
• Study does not appear to indicate how close in time the timal dose was to the VitaminD test
  it should be a minimum of 3 days - 10 days is much better to see the average/steady state
• 600,000 vitamin D loading doses – good response to both oral and muscular – Oct 2015
  Different than current study - just a single dose given, no second dose
• Injection category listing has 65 items along with related searches
• Large dose of vitamin D (200,000 IU) lasts for less than 90 days – Feb 2015

Poor Gut

• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
• Osteoporosis 4X more likely if poor gut (probably poor vitamin D absorption) – Aug 2017

Emergencies - fast response required

• 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
• Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
• Vitamin D injection of 600,000 IU (response by 10 individuals)– Sept 2017 nice chart
• Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
• Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
• 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015

Overview Loading of vitamin D contains the following

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

• Loading = restore = quick replacement by 1 or more doses
• Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • = 2.5 to 25 milligrams
• The size of the loading dose is a function of body weight - see below
  • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
• Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
  • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
• Loading is typically oral, but can be Injection (I.M,) and Topical
• Loading dose is ~3X faster if done topically or swished inside of the mouth
  • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
• The loading dose persists in the body for 1 - 3 months
  • The loading dose should be followed up with on-going maintenance dosing
  • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
• About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
  • it appears prudent to test with a small amount of vitamin D before giving a loading dose
  • The causes of a mild allergic reaction appear to be: (in order of occurrence)
  • 1) lack of magnesium - which can be easily added
  • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
  • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
  • 4) allergy of the gut to Vitamin D - alternative = topical