Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial
Journal of Pediatrics – online first
Hina J. Talib, MDcorrespondenceemail, Tulasi Ponnapakkam, PhD, Robert Gensure, MD, PhD, Hillel W. Cohen, DrPH, MPH, Susan M. Coupey, MD
A short 8 week trial
| 30 ng | |
| 50,000 IU weekly | 72% |
| 5,000 IU daily | 56% |
| 1,000 IU daily | 2% |
Much better if non-obese
See also VitaminDWiki
- African-Americans need only 20 ng of vitamin, not 30 ng, based on iPTH – Sept 2012
- Extra 4,000 IU daily raised the vitamin D levels of blacks to that of whites – July 2012
- Overview Dark Skin and Vitamin D
- Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013
- Many healthy African Americans got above 33 ng with 4,000 IU of vitamin D – RCT March 2014
That 12 week trial was more successful than the 8 week trial on this page
Note - vitamin D levels are often still rising even at 12 weeks
Response times are 12-20 weeks
Intervention AND Skin - Dark in VitaminDWiki
- Immune systems of overweight black women improved by monthly 60,000 IU Vitamin D – RCT Oct 2022
- Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022
- Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018
- Physical performance of black senior women not improved with 30 ng of Vitamin D – RCT Nov 2018
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Less response to 800 IU of Vitamin D by Africans than natives in Finland – RCT March 2018
- Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Monthly vitamin D (120,000 IU) got most overweight African Americans about 35 ng – RCT July 2015
- Cardiovascular death reduction in dark skin migrants by just 1,000 IU of vitamin D – May 2015
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Many healthy African Americans got above 33 ng with 4,000 IU of vitamin D – RCT March 2014
- Inflammation in African Americans not reduced with 3 months of 4000 IU of vitamin D – RCT Dec 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
Download the PDF from VitaminDWiki
Objectives
To compare 3 different treatment regimens for vitamin D deficiency in minority adolescents and to explore factors that impact treatment efficacy.
Study design
We conducted an 8-week, prospective, open-label, randomized clinical trial in an urban, academic, children's hospital.
- A total of 183 vitamin D-deficient adolescents,
- mean 25-hydroxyvitamin D or 25(OH)D 13.7 ± 3.9 ng/mL;
- mean age 16.6 ± 2.2 years,
were randomized into 3 vitamin D3 (cholecalciferol) treatment arms: 50 000 IU/wk; 5000 IU/d; and 1000 IU/d. Serum 25(OH)D and vitamin D binding protein (VDBP) levels were measured pre-and posttreatment; 122 (67%) participants completed posttreatment measures. Complete-case and multiple-imputation, intention-to-treat analyses were performed.
Results
Mean change in 25(OH)D level posttreatment was significantly different among the 3 arms, 24.9 ± 15.1 vs 21.0 ± 15.2 vs 6.2 ± 6.5 ng/mL, for 50 000 IU, 5000 IU, and 1000 IU doses, respectively, P < .001. Both high-dose treatments were effective in increasing the 25(OH)D level out of deficiency range (≥20 ng/mL) in more than 80% of participants, and 60% remained deficient after low-dose treatment. Only 72%, 56%, and 2% achieved vitamin D sufficiency (>30 ng/mL) with 50 000 IU, 5000 IU, and 1000 IU doses, respectively, P < .001.
Obese participants had substantially less mean change in 25(OH)D level after treatment than normal-weight participants, 13.7 ± 10.7 vs 21.9 ± 16.9 ng/mL, P < .001.
Mean baseline VDBP level was almost twice as high in Hispanic compared with black participants (P < .001) and did not alter treatment response or change with treatment.
Conclusions
Adult-sized adolescents require 8 weeks of high-dose cholecalciferol, at least 5000 IU/d, to correct deficiency. Obese adolescents have poorer response to treatment and may need higher doses than nonobese youth. Hispanic and black adolescents have different VDBP levels but similar treatment responses.
Trial registration: ClinicalTrials.gov: NCT01784029.