Lung transplant survival 4X more likely if take 2,000 IU of vitamin D daily – Oct 2024

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Post-Transplant Vitamin D Deficiency in Lung Transplant Recipients: Impact on Outcomes and Prognosis

Transpl Int, 24 October 2024 Volume 37 - 2024 | https://doi.org/10.3389/ti.2024.13313
Min Seo Ki,Min Seo Ki1,2Nam Eun KimNam Eun Kim3Ala WooAla Woo1Song Yee KimSong Yee Kim1Young Sam KimYoung Sam Kim1Ha Eun KimHa Eun Kim4Jin Gu LeeJin Gu Lee4Hyo Chae Paik,Hyo Chae Paik4,5 Moo Suk Park, Moo Suk Park1*

Despite the recognized clinical significance of vitamin D deficiency in other solid organ transplant recipients, its specific relevance in lung transplantation remains to be fully understood. In this study, we performed a retrospective observational study on the impact of vitamin D deficiency on clinical outcomes and prognosis in 125 lung transplant recipients (LTRs) from October 2014 to March 2020 at a university hospital in Seoul, South Korea. Among 125 LTRs, 51 patients (40.8%) were vitamin D deficient. LTRs in the vitamin D-deficient group exhibited a higher incidence of post-transplant pneumonia and overall mortality than those with normal vitamin D levels during the follow-up period. This trend persisted when subjects were stratified into vitamin D tertiles. Furthermore, post-transplant vitamin D levels and C-reactive protein (CRP) significantly impacted pneumonia incidence and survival outcomes. Prognosis also varied based on cumulative vitamin D supplementation after transplantation, with patients receiving higher cumulative supplementation demonstrating improved prognosis. Our findings underscore the importance of assessing and maintaining optimal vitamin D levels post-transplantation, suggesting a potential avenue for improving outcomes in lung transplant recipients, especially in mitigating infection risk and enhancing long-term survival. Further research into optimal vitamin D levels and supplementation strategies in this population is warranted.
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VitaminDWiki - Vitamin D helps organ transplant - many studies 33+ studies

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Note: Response to 2,000 IU will get half of healthy people to 30 ng level

Dose/response from 36 studies

solid line = mean response (50% above, 50% below)
Lower dashed line = 97.5% will have achieved the level
Note: Would need to give 7,000 IU of Vitamin D daily to get 97% of participants >30 ng

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