- Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation)
- See also VitaminDWiki - Tonsillectomy, tonsollitis and Vitamin D - many studies
- See also VitaminDWiki - Better than Daily
- 229+ VitaminDWiki pages have 50,000 or 60,000 IU in their title
- 91+ VitaminDWiki Non-daily Intervention pages with 50,000 in the title
Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation)
Sci Rep . 2023 May 17;13(1):8014. doi: 10.1038/s41598-023-33970-x.
Ayat Abu-Elnasr Awwad 1, Rehab A Hasan 2, Mohamed Ghazy Attia Hablas 3, Osama Mohammad Mohammad Abdelhay 4, Yahia Mohmmed Ahmed Dawood 5, Bothina Ahmed Mohamed 1, Khadiga Abdallah Abd Rabou 1, Taghreed Mahmoud Mohamed Salem 1, Marwa Elhady 6, Gehad Nabil Abd El-Aal 6, Ahmed Helal Elsayed Ahmed 7, Ahmed Ibrahim Mostafa Hasan 7, Asmaa Abd Elsalam Elmadbouly 8, Mohamed Basiouny Yahia 9, Walaa Mohamed Omar Ashry 10, Said S M M El Sayed 4, Ashraf M M Algendy 4, Ahmad M F Alkot 4, Mohamed F Farag 11, Ashraf Abdel Aty El Shenawy Emara 4, Fayez Mohammed Abd Elfattah Elbayoumy 12, Hany Fawzy Ali 9, Mohamed Morshdy Aldesoky 13, Raafat Abd-Rabow Abd-Eltwab 13, Samia M Manawy 14, Eman Mohamed Faruk 15
Inflammatory processes are increasingly attributed to macrophage polarization. Proinflammatory macrophages promote T helper (Th) 1 response, tissue repair, and Th2 responses. Detection of macrophages in tissue sections is facilitated by CD68. Our study is focused on the expression of CD68 and the estimation of proinflammatory cytokines in children's patients with chronic tonsillitis secondary to vitamin D supplementation. This hospital-based Randomized prospective case-control study was conducted on 80 children with chronic tonsillitis associated with vitamin D deficiency where (40 received vitamin D 50,000 IU weekly for 3-6 months and 40 received 5 ml distilled water as placebo). The serum 25-hydroxyvitamin D [25(OH)D] was measured using an Enzyme-linked immunosorbent assay on all included children. Different histological and immunohistochemical studies for the detection of CD68 were done. There was a significantly lower serum level of 25(OH)D in the placebo group versus the vitamin D group (P < 0.001). The levels of pro-inflammatory cytokines, TNFα, and IL-2 significantly increased in the placebo group as compared to the vitamin D group (P < 0.001). The increased level of IL-4 and IL-10 in the placebo group as compared to the vitamin D group was insignificant (P = 0.32, 0.82) respectively. Vitamin D supplementation alleviated the deleterious effect of chronic tonsillitis on the histological structure of the tonsil. Tonsillar tissues of the children in the control and vitamin D groups demonstrated a highly statistically significantly lower number of CD68 immunoexpressing cells compared with those in the placebo group (P < 0.001). Low vitamin D may play a role in chronic tonsillitis. Vitamin D supplementation could help reduce the occurrence of chronic tonsillitis in susceptible children.
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See also VitaminDWiki - Tonsillectomy, tonsollitis and Vitamin D - many studies
See also VitaminDWiki - Better than Daily
50,000 IU weekly is far better than 7,000 IU daily
- Less likely to forget
- Gets more vitamin D into the cells
229+ VitaminDWiki pages have 50,000 or 60,000 IU in their title
Note: India uses 60,000 IU capsules
91+ VitaminDWiki Non-daily Intervention pages with 50,000 in the title
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