Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor – March 2022

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Vitamin D and Its Target Genes

Nutrients 2022, 14(7), 1354; https://doi.org/10.3390/nu14071354
by Carsten Carlberg 1,2 ORCID

1 Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, PL-10-748 Olsztyn, Poland
2 Institute of Biomedicine, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland

The vitamin D metabolite 1α,25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the transcription factor vitamin D receptor (VDR). In many tissues and cell types, VDR binds in a ligand-dependent fashion to thousands of genomic loci and modulates, via local chromatin changes, the expression of hundreds of primary target genes. Thus, the epigenome and transcriptome of VDR-expressing cells is directly affected by vitamin D. Vitamin D target genes encode for proteins with a large variety of physiological functions, ranging from the control of calcium homeostasis, innate and adaptive immunity, to cellular differentiation. This review will discuss VDR’s binding to genomic DNA, as well as its genome-wide locations and interaction with partner proteins, in the context of chromatin. This information will be integrated into a model of vitamin D signaling, explaining the regulation of vitamin D target genes.
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VitaminDWiki - Genetics category starts:

343 articles in the Genetics category

see also

• Vitamin D Receptor has 530 items
• Vitamin D Binding Protein = GC has 178 items
• CYP27B1 has 63 items
• CYP24A1 in title of 39+ items
• CYP2R1 25+ items
• Calcidiol has 48 items
• Calcitriol has 62 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
      especially if it is one of 51+ diseases related to Vitamin D Receptor
  2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
  3) DNA and VDR tests - 100 to 200 dollars $100 to $250
  4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
     Genes are good, have enough Magnesium, etc.
  5) Back Pain
     probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
  • The founder of VitaminDWiki took action with clues #3&5

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Gene	# of pages	Location
CYP27A1	449 (Sept 2019)	Liver
*CYP2R1	826 (Sept 2019)	Liver & Tissue
CYP27B1	1430   (Sept 2019)	Kidney & Tissue
CYP24A1	28 in title - May 2022]	excrete excess

• Vitamins regulate some human genes – Feb 2020
• The genetics of vitamin D – Oct 2018
• Does survival of the less fit mean less health (poor genes may be inherited)
  • genes getting worse over generations
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019

Sample of studies

• Vitamin D genes – Review June 2022
• Vitamin D effects on over 300 genes varies with genetics and levels – Dec 2020
• Vitamin D genes are important, update – Sept 2020
• Low Vitamin D in blood is associated with 69 genes, only 6 of which are reported on - Feb 2020
• Does survival of the less fit mean less health (poor genes may be inherited)
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• Vitamin D affects at least 3,023 DNA locations – July 2018
• 2,776 vitamin D receptor binding sites - April 2014
• 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016
• Genes which regulate active vitamin D worsen with age – Oct 2016
• Health problems that run in families are often associated with low vitamin D
• Genes and Vitamin D – literature review – Dec 2015

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VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation