Loading...
 
Toggle Health Problems and D

Some vitamin D is stored in skeletal muscles – multiple studies

Unfortunately, none of the studies appear to mention what % of 25(OH)D (Calcidiol) is stored in muscles

Vitamin D and Skeletal Muscle: Current Concepts From Preclinical Studies - Dec 2021

JBMR® Plus (WOA), Vol. 5, No. 12, December 2021, DOI: 10.1002/jbm4.10575
Christian M. Girgis1,2,3© and Tara C. Brennan-Speranza1,4,5
1 Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia 2Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia 3Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia 4School of Medical Sciences, University of Sydney, Sydney, NSW, Australia 5School of Public Health, University of Sydney, Sydney, NSW, Australia

Muscle weakness has been recognized as a hallmark feature of vitamin D deficiency for many years. Until recently, the direct biomo- lecular effects of vitamin Don skeletal muscle have been unclear. Although in the past, some reservations have been raised regarding the expression of the vitamin D receptor in muscle tissue, this special issue review article outlines the clear evidence from preclinical studies for not only the expression of the receptor in muscle but also the roles of vitamin D activity in muscle development, mass, and strength. Additionally, muscle may also serve as a dynamic storage site for vitamin D, and play a central role in the maintenance of circulating 25-hydroxy vitamin D levels during periods of low sun exposure.
 Download the PDF from VitaminDWiki

References

Skeletal muscles references

  1. Mason RS, Sequeira VB, Gordon-Thomson C. Vitamin D: the light side of sunshine. EurJ Clin Nutr. 2011;65(9):986-993.
  2. Kutuzova GD, Deluca HF. Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties. Arch Bio- chem Biophys. 2004;432(2):152-166.
  3. Fujita H, Sugimoto K, Inatomi S, et al. Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell. 2008;19(5):1912-1921.
  4. Bouillon R, Van Schoor NM, Gielen E, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. JClin Endocrinol Metab. 2013;98(8):E1283-E1304.
  5. Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008; 29(6):726-776.
  6. Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34(1):33-83.
  7. Girgis CM, Clifton-Bligh RJ, Turner N,Lau SL, Gunton JE. Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf). 2014;80(2):169-181.
  8. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr. 2004;80(3):752-758.
  9. Girgis CM, Clifton-Bligh RJ, Mokbel N, Cheng K, Gunton JE. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology. 2014;155(2):347-357.
  10. Brumbaugh PF, Haussler MR. 1 Alpha,25-dihydroxycholecalciferol receptors in intestine. I. Association of 1 alpha,25--dihydroxycholecalciferol with intestinal mucosa chromatin. J Biol Chem. 1974;249(4):1251-1257.
  11. Girgis CM. Vitamin D and skeletal muscle. In Feldman DJ, Pike W, Bouillon R, Giovanucci E, Goltzman D, Hewison M, eds. Vitamin D. 4th ed. Elsevier; 2018 pp 597-613.
  12. Norman AW, Mizwicki MT, Norman DP. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov. 2004;3(1):27-41.
  13. Bischoff HA, Borchers M, Gudat F, et al. In situ detection of dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001;33(1):19-24.
  14. Buitrago C, Boland R. Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Bio- chem Mol Biol. 2010;121(1-2):169-175.
  15. Wang Y, DeLuca HF. Is the vitamin d receptor found in muscle? Endocrinology. 2011;152(2):354-363.
  16. Girgis CM, Mokbel N, Minn Cha K, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014;155(9):3227-3237.
  17. Olsson K, Saini A, Stromberg A, et al. Evidence for vitamin D receptor expression and direct effects of 1alpha,25(OH)2D3 in human skeletal muscle precursor cells. Endocrinology. 2016;157(1):98-111.
  18. Cheng C, Alexander R, Min R, et al. Understanding transcriptional regulation by integrative analysis of transcription factor binding data. Genome Res. 2012;22(9):1658-1667.
  19. Lee SM, Bishop KA, Goellner JJ, O'Brien CA, Pike JW. Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Endocrinology. 2014;155(6):2064-2076.
  20. Ceglia L, Niramitmahapanya S, Morais MD, et al. A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. JClin Endocrinol Metab. 2013;98(12):E1927-E1935.
  21. Pojednic RM, Ceglia L, Olsson K, et al. Effects of1-25 dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin d receptor in human skeletal muscle cells. Calcif Tissue Int. 2015;96(3):256-263.
  22. Brennan-Speranza TC, Mor D, Mason RS, et al. Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee. J Steroid Bio- chem Mol Biol. 2017;173:180-184.
  23. Johnson JA, Grande JP, Roche PC, Kumar R. Ontogeny of the1-25– dihydroxyvitamin D3 receptor in fetal rat bone. J Bone Miner Res. 1996;11(1):56-61.
  24. Makanae Y, Ogasawara R, Sato K, et al. Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle. Exp Physiol. 2015;100(10):1168-1176.
  25. Srikuea R, Zhang X, Park-Sarge OK, Esser KA. VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: potential role in suppression of myoblast proliferation. Am J Physiol Cell Physiol. 2012;303(4):C396-C405.
  26. Braga MSZ, Norris KC, Ferrini MG, Artaza JN. Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells. Endocr Connect. 2017;6(3):139-150.
  27. Yin H, Price F, Rudnicki MA. Satellite cells and the muscle stem cell niche. Physiol Rev. 2013;93(1):23-67.
  28. Garcia LA, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)(2)vitamin D (3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C (12) skeletal muscle cells. J Steroid Biochem Mol Biol. 2013;133:1-11.
  29. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011; 152(8):2976-2986.
  30. Romeu Montenegro K, Carlessi R, Cruzat V, Newsholme P. Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics. J Steroid Biochem Mol Biol. 2019;193:105423.
  31. van der Meijden K, Bravenboer N, Dirks NF, et al. Effects of 1,25(OH)2 D3 and 25(Oh)D3 on C2C12 myoblast proliferation, differentiation, and myotube hypertrophy. J Cell Physiol. 2016;231(11):2517-2528.
  32. Hayakawa N, Fukumura J, Yasuno H, Fujimoto-Ouchi K, Kitamura H. 1a,25(OH)2 D3 downregulates gene expression levels of muscle ubi- quitin ligases MAFbx and MuRF1 in human myotubes. Biomed Res. 2015;36(2):71-80.
  33. Tamilselvan B, Seshadri K, Venkatraman G. Role of vitamin D on the expression of glucose transporters in L6 myotubes. Indian J Endocrinol Metab. 2013;17(7):326-328.
  34. Salles J, Chanet A, Giraudet C, et al. 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res. 2013;57(12):2137-2146.
  35. Manna P, Achari AE, Jain SK. 1,25(OH)2-vitamin D3 upregulates glucose uptake mediated by SIRT1/IRS1/GLUT4 signaling cascade in C2C12 myotubes. Mol Cell Biochem. 2018;444(1):103-108.
  36. Chang E. 1,25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells. Molecules. 2019;24(21):3903.
  37. Chang E, Kim Y. Vitamin D ameliorates fat accumulation with AMPK/- SIRT1 activity in C2C12 skeletal muscle cells. Nutrients. 2019;11(11): 2806.
  38. Endo I, Inoue D, Mitsui T, et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. 2003;144(12):5138-5144.
  39. Tanaka M, Kishimoto KN, Okuno H, Saito H, Itoi E. Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines. Muscle Nerve. 2014;49(5):700-708.
  40. Antinozzi C, Corinaldesi C, Giordano C, et al. Potential role for the VDR agonist elocalcitol in metabolic control: evidences in human skeletal muscle cells. J Steroid Biochem Mol Biol. 2017;167:169-181.
  41. Ryan ZC, Craig TA, Folmes CD, et al. 1alpha,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells. J Biol Chem. 2016;291(3):1514-1528.
  42. Capiati DA, Vazquez G, Tellez Inön MT, Boland RL. Role of protein kinase C in 1,25(OH)(2)-vitamin D(3) modulation of intracellular calcium during development of skeletal muscle cells in culture. J Cell Biochem. 2000;77(2):200-212.
  43. Vazquez G, Boland R, de Boland AR. Modulation by 1,25(OH) 2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts. Biochim Biophys Acta. 1995;1269(1):91-97.
  44. Artaza JN, Norris KC. Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol. 2009;200(2):207-221.
  45. Girgis CM, Cha KM, Houweling PJ, et al. Vitamin D receptor ablation and vitamin D deficiency result in reduced grip strength, altered muscle fibers, and increased myostatin in mice. Calcif Tissue Int. 2015;97(6):602-610.
  46. Chen S, Villalta SA, Agrawal DK. FOXO1 mediates vitamin D deficiency-induced insulin resistance in skeletal muscle. J Bone Miner Res. 2016;31(3):585-595.
  47. Girgis CM, Cha KM, So B, et al. Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function. J Cachexia Sarcopenia Muscle. 2019;10(6):1228-1240.
  48. Bass JJ, Nakhuda A, Deane CS, et al. Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy. Mol Metab. 2020;42:101059.
  49. Gifondorwa DJ, Thompson TD, Wiley J, et al. Vitamin D and/or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation. Muscle Nerve. 2016;54(6):1120-1132.
  50. Bhat M, Kalam R, Qadri SS, Madabushi S, Ismail A. Vitamin D deficiency induced muscle wasting occurs through the ubiquitin protea- some pathway and is partially corrected by calcium in male rats. Endocrinology. 2013;154(11):4018-4029.
  51. Choi M, ParkH,ChoS, Lee M. Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high- intensity exercise in SD rats. Cytokine. 2013;63(1):27-35.
  52. Stratos I, Li Z, Herlyn P, et al. Vitamin D increases cellular turnover and functionally restores the skeletal muscle after crush injury in rats. Am J Pathol. 2013;182(3):895-904.
  53. Ke CY, Yang FL, Wu WT, et al. Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int J Med Sci. 2016; 13(2):147-153.
  54. Akagawa M, Miyakoshi N, Kasukawa Y, et al. Effects of activated vitamin D, alfacalcidol, and low-intensity aerobic exercise on osteopenia and muscle atrophy in type 2 diabetes mellitus model rats. PLoS One. 2018;13(10):e0204857.
  55. Nadimi H, Djazayery A, Javanbakht MH, et al.The effect of vitamin D supplementation on serum and muscle Irisin levels, and FNDC5 expression in diabetic rats. Rep Biochem Mol Biol. 2019;8(3):236-243.
  56. Benetti E, Mastrocola R, Chiazza F, et al. Effects of vitamin Don insulin resistance and myosteatosis in diet-induced obese mice. PLoS One. 2018;13(1):e0189707.
  57. Hayes A, Rybalka E, Debruin DA, Hanson ED, Scott D, Sanders K. The effect of yearly-dose vitamin D supplementation on muscle function in mice. Nutrients. 2019;11(5):1097.
  58. Sanders KM, Stuart AL, Williamson EJ, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815-1822.
  59. Pojednic RM, Ceglia L, Lichtenstein AH, Dawson-Hughes B, Fielding RA. Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle. Endocrine. 2015;49(2):512-520.
  60. Barker T, Henriksen VT, Martins TB, et al. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 2013;5(4):1253- 1275.
  61. Barker T, Martins TB, Hill HR, et al. Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans. Cytokine. 2014;65(2):134-137.
  62. Hassan-Smith ZK, Jenkinson C, Hernandez I, et al. 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLoS One. 2017; 12(2):e0170665. https://doi.org/10.1371/journal.pone.0170665.
  63. Clements MR, Davies M, Fraser DR, Lumb GA, Mawer EB, Adams PH. Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism. Clin Sci (Lond). 1987;73(6):659-664.
  64. Datta P, Philipsen PA, Olsen P, et al. The half-life of 25(OH)D after UVB exposure depends on gender and vitamin D receptor polymorphism but mainly on the start level. Photochem Photobiol Sci. 2017;16(6): 985-995.
  65. Mason RS, Lissner D, Posen S, Norman AW. Blood concentrations of dihydroxylated vitamin D metabolites after an oral dose. Br Med J. 1980;280(6212):449-450.
  66. Haddad JG, Fraser DR, Lawson DE. Vitamin D plasma binding protein. Turnover and fate in the rabbit. J Clin Invest. 1981;67(5):1550-1560.
  67. Mason RS, Rybchyn MS, Abboud M, Brennan-Speranza TC, Fraser DR. The role of skeletal muscle in maintaining vitamin D status in winter. Curr Dev Nutr. 2019;3(10):nzz087.
  68. Abboud M, Gordon-Thomson C, Hoy AJ, et al. Uptake of 25-hydroxyvitamin D by muscle and fat cells. J Steroid Biochem Mol Biol. 2014;144:232-236.
  69. Clements MR, Fraser DR. Vitamin D supply to the rat fetus and neonate. J Clin Invest. 1988;81 (6):1768-1773.
  70. Abboud M, Puglisi DA, Davies BN, et al. Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology. 2013;154(9):3022-3030.
  71. Gressner OA, Lahme B, Gressner AM. Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor. Clin Chim Acta. 2008; 390(1-2):28-37.
  72. Abboud M, Rybchyn MS, Liu J, et al. The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells. J Steroid Biochem Mol Biol. 2017;173:173-179.
  73. Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology. 2006;147(12):5542-5548.
  74. Capiati DA, Vazquez G, Boland RL. Protein kinase C alpha modulates the Ca2+ influx phase of the Ca2+ response to 1alpha,25-dihydroxy- vitamin-D3 in skeletal muscle cells. Horm Metab Res. 2001;33(4): 201-206.
  75. Boland RL. VDR activation of intracellular signaling pathways in skeletal muscle. Mol Cell Endocrinol. 2011;347(1-2):11-16

The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter - July 2019

Current Developments in Nutrition, Volume 3, Issue 10, October 2019, nzz087, https://doi.org/10.1093/cdn/nzz087
Rebecca S Mason, Mark S Rybchyn, Myriam Abboud, Tara C Brennan-Speranza, David R Fraser

The status of vitamin D is determined mainly by its formation in skin by the photochemical action of solar UVB light (wavelength 290–320 nm) on the precursor 7-dehydrocholesterol. Because of seasonal variation in intensity of solar UV light, vitamin D status falls in winter and rises in summer. It has been presumed that there is no functional store of vitamin D. Thus, to avoid deficiency, a nutritional supply would be required in winter. However, there is now evidence that the main circulating metabolite of vitamin D, 25-hydroxyvitamin D, accumulates in skeletal muscle cells, which provide a functional store during the winter months. The mechanism is mediated by muscle cell uptake of circulating vitamin D–binding protein (DBP) through a megalin-cubilin membrane transport process. DBP then binds to cytoplasmic actin to provide an array of high-affinity binding sites for 25-hydroxyvitamin D [25(OH)D]. The repeated passage of 25(OH)D into and out of muscle cells would account for its long residence time in blood.
 Download the PDF from VitaminDWiki

Skeletal Muscle and the Maintenance of Vitamin D Status - 2020

Nutrients 2020, 12(11), 3270; https://doi.org/10.3390/nu12113270
by Mark S. Rybchyn 1ORCID,Myriam Abboud 1,2ORCID,David A. Puglisi 1,Clare Gordon-Thomson 1,Tara C. Brennan-Speranza 1,3,Rebecca S. Mason 1ORCID andDavid R. Fraser 4,*ORCID

Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cytoplasm where it binds to cytoplasmic actin. This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. This uptake and release of 25(OH)D by muscle accounts for the very long half-life of this metabolite in the circulation. Since 25(OH)D concentration in the blood declines in winter, its cycling in and out of muscle cells appears to be upregulated. Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. This mechanism appears to have evolved to maintain an adequate vitamin D status in winter.
 Download the PDF from VitaminDWiki

VitaminDWiki - Getting Vitamin D into your body chart

Image

142+ VitaminDWiki pages with MUSCLE, etc in the title

This list is automatically updated

Created by admin. Last Modification: Thursday February 29, 2024 16:50:47 GMT-0000 by admin. (Version 16)
Some vitamin D is stored in skeletal muscles – multiple studies        
3387 visitors, last modified 29 Feb, 2024,
(Cached) Printer Friendly Follow this page for updates
Page actions
Refresh Print
Edit Files 3