Effect of vitamin D supplementation as a single dose on the nutritional status of vitamin D
Revista Chilena de Pediatría 2020, 91 (5): 684-690 (study is in Spanish)
Johanna Pacheco-Acosta, Fernando Pizarro
100K was better because more of them have vitamin D levels between 30 and 40 ng
Infant-Child category has 854 items and starts with
- No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
- 400 IU Vitamin D is no longer enough
Was OK in the past century, but D levels have been dropping for a great many reasons.
FDA doubles the amount of vitamin D permitted in milk – July 2016
- No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
- Review of 400 IU to 2000 IU daily and higher if non-daily
- Fewer pre-infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
- 1600 IU was the conclusion of three JAMA studies
1000 IU recommended in France and Finland – 2013 - appears to be a good level
- 5X less mite allergy after add vitamin D
- Child bone fractures with low vitamin D were 55X more likely to need surgery
- 75 % of SIDS had low vitamin D
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better – Feb 2022
- Preemies should have vitamin D supplements – reaching an agreement – April 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
Having a good level of vitamin D cuts in half the amount of:
- Asthma, Chronic illness, Doctor visits, Allergies, infection
Respiratory Tract Infection, Growing pains, Bed wetting
Need even more IUs of vitamin D to get a good level if;
- Have little vitamin D: premie, twin, mother did not get much sun access
- Get little vitamin D: dark skin, little access to sun
- Vitamin D is consumed faster than normal due to sickness
- Older (need at least 100 IU/kilogram, far more if obese)
- Not get any vitamin D from formula (breast fed) or (fortified) milk
Note – formula does not even provide 400 IU of vitamin D daily
Infants-Children need Vitamin D
- Sun is great – well known for 1,000’s of years.
US govt (1934) even said infants should be out in the sun
- One country recommended 2,000 IU daily for decades – with no known problems
- As with adults, infants and children can have loading doses and rarely need tests
- Daily dose appears to be best, but monthly seems OK
- Vitamin D is typically given to infants in the form of drops
big difference in taste between brands
can also use water-soluable form of vitamin D in milk, food, juice,
- Infants have evolved to get a big boost of vitamin D immediately after birth
Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
- 100 IU per kg of infant July 2011, Poland etc.
More than 100 IU/kg is probably better
854 items in the category Infant/Child See also
- 34 pages in VitaminDWiki had BREASTFE*in title as of Jan 2022
- "BIRTH DEFECTS" 172 items as of July 2016
- Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
- 153 VitaminDWiki pages contained PRETERM or PREEMIE in title as of Nov 2024
- "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
- Overview of Rickets and Vitamin D
- Youth category listing has
175 items along with related searches
- Down's syndrome and low vitamin D - several studies
- Rett syndrome associated with low vitamin D, treated by Omega-3
Better than Daily category listing has 33 items
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
Items in both categories Infant-Child and Intervention - non daily are listed here:
-
Children had a better response to Vitamin D given every 2 weeks than daily – RCT Aug 2024
-
Monthly vitamin D dosing better for children than daily (again) - Oct 2023
-
Bone fractures of children not reduced if given little vitamin D, no Calcium etc. – RCT May 2023
-
Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
-
Response to infant 2,000 IU Vitamin D daily was in 194 ng, monthly dosing was 20% less – RCT May 2023
-
Monthly 120,000 IU of Vitamin D while breastfeeding was good – RCT Jan 2022
-
Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
-
Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
-
Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
-
Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017
-
Vitamin D required for breastfed infants – daily or monthly, infant or mother – Jan 2017
-
Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016
-
Infant infection reduced by half with vitamin D supplementation – RCT May 2016
-
Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
-
Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
-
Growing pains reduced 60 percent by monthly Vitamin D – March 2014
-
Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
 Download the PDF from VitaminDWiki
INTRODUCTION: Infants are a group at risk of vitamin D (VD) deficiency. The administration of 400 IU of VD per day during the first year of life does not achieve 100% adherence. A single dose of 100,000 IU of oral VD is safe in newborns.
OBJECTIVE: To compare the effect of oral administration of VD between a single dose of 100,000 IU at one month of age vs daily doses of 400 IU on serum concentrations of VD, at 6 months of age.
SUBJECTS AND METHOD: Randomized clinical trial, without masking. 84 healthy infants were included at 1 month of age, randomized to the study group (SG) receiving a single oral dose of 100,000 IU or to the control group (CG), who received daily oral doses of VD of 400 IU from the 1st to the 6th month of life. At 6 months of life, the serum concentration of VD was determined.
RESULTS: 65 infants completed the study, 36 in SG and 29 in CG. No VD deficiency was found.
VD insufficient was 5.5% and 6.8% in the SG and CG, respectively.
The serum concentration of VD at six months of age was 38.8 ± 5.2 ng/ml and 39.7 ± 6.3 ng/ml for the SG and CG, respectively (NS).
CONCLUSIONS: Supplementation of 100,000 IU of VD at one month age achieves serum concentrations of VD at 6 months of life similar to the administration of daily doses of 400 IU of VD from the 1st to the 6th month.
- - - - - Clipped from PDF- - - - -
A randomized clinical trial was conducted, without blinding, which included 84 healthy infants (42 per group) between August 15, 2015, and July 15, 2016, who attend well-baby checkups at the Padre Vicente Irarrázaval Family Health Center (CESFAM), Santia go (Latitude 33°S). We included full-term newborns between 25 and 45 days of age, fed with exclusive or mainly breast milk, with the written informed consent of their parents or representative of legal age.
Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
4887 visitors, last modified 10 Jun, 2022,
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100K monthly.jpg
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100K English.pdf
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- No consensus on MINIMUM International Units (IU) for healthy infant of normal weight
- 400 IU Vitamin D is no longer enough
Was OK in the past century, but D levels have been dropping for a great many reasons.
FDA doubles the amount of vitamin D permitted in milk – July 2016 - No consensus: range is 600 to 1600 IU – based on many randomized controlled trials
- Review of 400 IU to 2000 IU daily and higher if non-daily
- Fewer pre-infants were vitamin D deficient when they got 800 IU – RCT Feb 2014
- 1600 IU was the conclusion of three JAMA studies
1000 IU recommended in France and Finland – 2013 - appears to be a good level - 5X less mite allergy after add vitamin D
- Child bone fractures with low vitamin D were 55X more likely to need surgery
- 75 % of SIDS had low vitamin D
- Children stayed in ICU 3.5 days longer if low vitamin D – Dec 2015
- 5 out of 6 children who died in pediatric critical care unit had low vitamin D – May 2014
- Infants have gotten free 400 IU of vitamin D in Turkey since 2005, More for longer would be even better – Feb 2022
- Preemies should have vitamin D supplements – reaching an agreement – April 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
Having a good level of vitamin D cuts in half the amount of:
- Asthma, Chronic illness, Doctor visits, Allergies, infection
Respiratory Tract Infection, Growing pains, Bed wetting
Need even more IUs of vitamin D to get a good level if;
- Have little vitamin D: premie, twin, mother did not get much sun access
- Get little vitamin D: dark skin, little access to sun
- Vitamin D is consumed faster than normal due to sickness
- Older (need at least 100 IU/kilogram, far more if obese)
- Not get any vitamin D from formula (breast fed) or (fortified) milk
Note – formula does not even provide 400 IU of vitamin D daily
Infants-Children need Vitamin D
- Sun is great – well known for 1,000’s of years.
US govt (1934) even said infants should be out in the sun - One country recommended 2,000 IU daily for decades – with no known problems
- As with adults, infants and children can have loading doses and rarely need tests
- Daily dose appears to be best, but monthly seems OK
- Vitamin D is typically given to infants in the form of drops
big difference in taste between brands
can also use water-soluable form of vitamin D in milk, food, juice, - Infants have evolved to get a big boost of vitamin D immediately after birth
Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare - 100 IU per kg of infant July 2011, Poland etc.
More than 100 IU/kg is probably better 854 items in the category Infant/Child See also - 34 pages in VitaminDWiki had BREASTFE*in title as of Jan 2022
- "BIRTH DEFECTS" 172 items as of July 2016
- Stunting OR “low birth weight” OR LBW OR preemie OR preemies OR preterm 1940 items as of Oct 2018
- 153 VitaminDWiki pages contained PRETERM or PREEMIE in title as of Nov 2024
- "SUDDEN INFANT DEATH" OR SIDS 214 items as of Dec 2020
- Overview of Rickets and Vitamin D
- Youth category listing has
175 items along with related searches - Down's syndrome and low vitamin D - several studies
- Rett syndrome associated with low vitamin D, treated by Omega-3
33 items - 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
Items in both categories Infant-Child and Intervention - non daily are listed here:- Children had a better response to Vitamin D given every 2 weeks than daily – RCT Aug 2024
- Monthly vitamin D dosing better for children than daily (again) - Oct 2023
- Bone fractures of children not reduced if given little vitamin D, no Calcium etc. – RCT May 2023
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- Response to infant 2,000 IU Vitamin D daily was in 194 ng, monthly dosing was 20% less – RCT May 2023
- Monthly 120,000 IU of Vitamin D while breastfeeding was good – RCT Jan 2022
- Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- Breastfeeding mothers and Vitamin D: supplement only themselves usually, 4 out of 10 used monthly rather than daily – Jan 2017
- Vitamin D required for breastfed infants – daily or monthly, infant or mother – Jan 2017
- Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016
- Infant infection reduced by half with vitamin D supplementation – RCT May 2016
- Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013
 Download the PDF from VitaminDWiki
INTRODUCTION: Infants are a group at risk of vitamin D (VD) deficiency. The administration of 400 IU of VD per day during the first year of life does not achieve 100% adherence. A single dose of 100,000 IU of oral VD is safe in newborns.
OBJECTIVE: To compare the effect of oral administration of VD between a single dose of 100,000 IU at one month of age vs daily doses of 400 IU on serum concentrations of VD, at 6 months of age.
SUBJECTS AND METHOD: Randomized clinical trial, without masking. 84 healthy infants were included at 1 month of age, randomized to the study group (SG) receiving a single oral dose of 100,000 IU or to the control group (CG), who received daily oral doses of VD of 400 IU from the 1st to the 6th month of life. At 6 months of life, the serum concentration of VD was determined.
RESULTS: 65 infants completed the study, 36 in SG and 29 in CG. No VD deficiency was found.
VD insufficient was 5.5% and 6.8% in the SG and CG, respectively.
The serum concentration of VD at six months of age was 38.8 ± 5.2 ng/ml and 39.7 ± 6.3 ng/ml for the SG and CG, respectively (NS).CONCLUSIONS: Supplementation of 100,000 IU of VD at one month age achieves serum concentrations of VD at 6 months of life similar to the administration of daily doses of 400 IU of VD from the 1st to the 6th month.
- - - - - Clipped from PDF- - - - -
A randomized clinical trial was conducted, without blinding, which included 84 healthy infants (42 per group) between August 15, 2015, and July 15, 2016, who attend well-baby checkups at the Padre Vicente Irarrázaval Family Health Center (CESFAM), Santia go (Latitude 33°S). We included full-term newborns between 25 and 45 days of age, fed with exclusive or mainly breast milk, with the written informed consent of their parents or representative of legal age.Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 20204887 visitors, last modified 10 Jun, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 14840 100K monthly.jpg admin 10 Jan, 2021 28.64 Kb 401 14839 100K English.pdf admin 10 Jan, 2021 511.59 Kb 365