The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females.
Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784
Imga NN1, Berker D1, Can B1, Guler S1.
This study: Daily vs. Weekly 50,000 IU oral Vitamin D for 8 weeks
Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs
- One pill every two weeks gives you all the vitamin D most adults need
- Which includes "32 health problems fought by 50,000 Vitamin D weekly "
A sampling of the many RCT which found weekly to work well (often 50,000 IU was used)
- 50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018
- Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
- Athletes helped by weekly 50,000 IU Vitamin D – RCT Aug 2019
Weekly may be BETTER than daily
- Vitamin D dosing - weekly may be better than daily – video Aug 2018
- Weekly Vitamin D to mother after birth much better than daily - RCT Aug 2018
Non weekly
- Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
- Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017
272 items in category Intervention - non daily 1 or 2 per month may be BETTER than daily
- 50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
- 50,000 every two weeks is slightly better than 100,000 once a month
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing had higher response than 3 per month – RCT Jan 2018
Take vitamin D3 daily, weekly, or bi-weekly has the following
- Notional chart for Vitamin D supplementation for levels < 30 nanograms
- Notional chart of Vitamin D benefit vs dosing frequency for > 50 nanograms
Notional chart for Vitamin D supplementation for levels < 30 nanograms
Download the PDF from VitaminDWiki
Note: vitamin D levels dropped by the 6th month asthere was no dosing after the 8th weekVitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.
MATERIAL AND METHODS:
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups:- daily continuous oral,
- loading dose of weekly oral
- and monthly intramuscular.
All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.
RESULTS:
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p < 0.001), but between the third and sixth months it was not changed (p = 0.783).CONCLUSIONS:
- Oral daily regimen in non-obese patients and
- loading weekly oral regimen in obese patients
were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.
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