Vitamin D in inflammatory bowel disease: from biology to clinical implications
Complementary Therapies in Medicine, https://doi.org/10.1016/j.ctim.2019.08.023
Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Seyed Mahdi Hassanian, Ali Mottaghi-Moghaddam, Anahita Ghazaghi, Maryam Ghandehari, Mohadese Alizade-Noghani, Majid Khazaei, Majid Ghayour-Mobarhan, Gordon A. Ferns, Seyed Mohammad Reza Parizadeh, Amir Avan
Most of the trials used
1) too little D3,
2) non gut-friendly D3, or
3) Vitamin D2
Overview Gut and vitamin D has the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019) - All items in category gut and vitamin D
208 items Overview Gut and vitamin D contains gut-friendly information
Gut-friendly, Sublingual, injection, topical, UV, sunshineGetting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gutBio Form Speed Duration 10 Injection ($$$)
or Calcidiol or CalcitriolD - Slow
C -FastLong 10 Sun/UVB Slow Long 10 Topical
(skin patch/cream, vagina)Slow
Fast nanoNormal 9 Nanoemulsion -mucosal
perhaps activates VDRFast Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 4 Sublingual/spray
(some goes into gut)Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal 10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 monthsGut category listing contains the following
208 items in GUT category - see also Overview Gut and vitamin D, - Ulcerative Colitis and Vitamin D - many studies 12+
- "celiac disease" OR CD 1830 items July 2019
- IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
- Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .
40 items along with related searches.
Inflammatory Bowel Disease – proposed Vitamin D protocol – Oct 2019Download the PDF from Sci-Hub via VitaminDWiki
Highlights:
- Vitamin D deficiency is a major concern in general population as well as in IBD patients.
- The main focus of most of present clinical studies are on the inflammatory state rather than evaluation clinical outcomes.
- The exact dose of vitamin D supplementation in IBD patients has not been studied systematically in clinical trials which requires further studies with greater sample size with more emphasizes on every vitamin D sources especially the sun exposure.
Inflammatory bowel disease (IBD) Is a chronic Immune-medlated Inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains unknown. Vitamin D Is an Important mlcronutrlent that plays a critical biological role In various processes In human tissues. However, the relationship between disruption of the gut mlcroblota and the development of IBD Is unclear. Some studies suggest that IBD Is the cause of disrupted gut mlcroblota while others propose that gut mlcroblota Itself can lead to development of IBD. Regardless of this complexity, It has emerged that vitamin D Is an Immunoregulatory factor that plays a significant role In the pathogenesis of IBD by affecting the gut mlcroblome and the Inflammatory response. It has been reported that 38.1% of CD patients and 31.6% of UC patients suffer from vitamin D deficiency (VDD). In this review, we aimed to evaluate the association between VDD and IBD, summarizing recent clinical studies examining the effect of low vitamin D and the role of vitamin D supplementation on IBD clinical outcomes.
Inflammatory Bowel Disease Inflammation and Vitamin D – scores of studies and trials – Aug 2019Printer Friendly Follow this page for updates8921 visitors, last modified 29 Oct, 2019, This page is in the following categories (# of items in each category)