Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial
Experimental and Theraputic Medicine, September 2016, Volume 12 Issue 3, DOI: 10.3892/etm.2016.3515
Qingying Zhang Yan Cheng Mulan He Tingting Li Ziwen Ma Haidong Cheng
Insulin
HOMA-IR
TAC (antioxident)
GSH (antioxident)
GDM detected before week 12
Dosing from week 24-28 of pregnancy to women not getting any other treatment
| Control | Low dose | Medium Dose | High dose | |
| Dose | 0 | 200 IU daily | 50,000 IU every 4 weeks | 50,000 IU every 2 weeks |
| Avg daily | 0 IU | 200 IU | 1,800 IU | 3,600 IU |
See also VitaminDWiki
- One pill every two weeks gives you all the vitamin D most adults need 50.000 IU every 2 weeks
- 4000 IU Vitamin D Safe and Effective For Healthy Pregnant Women – RCT June 2011
- Women taking 4,000 IU reduced pregnancy risks in half RCT May 2010
Pages listed in BOTH the categories Diabetes and Pregnancy
- Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023
- Diabetes 30% more likely in those with low birth weight - June 2023
- Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022
- Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017
- Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016
- Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007
- Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015
- Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013
- Vitamin D protects against many types of health problems – review May 2013
- Dr. Holick video on vitamin D - March 2013
- Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for details
Problem | Vit. D Reduces | Evidence | ||
| 0. Chance of not conceiving | 3.4 times | Observe | ||
| 1. Miscarriage | 2.5 times | Observe | ||
| 2. Pre-eclampsia | 3.6 times | RCT | ||
| 3. Gestational Diabetes | 3 times | RCT | ||
| 4. Good 2nd trimester sleep quality | 3.5 times | Observe | ||
| 5. Premature birth | 2 times | RCT | ||
| 6. C-section - unplanned | 1.6 times | Observe | ||
| Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 | ||
| 7. Depression AFTER pregnancy | 1.4 times | RCT | ||
| 8. Small for Gestational Age | 1.6 times | meta-analysis | ||
| 9. Infant height, weight, head size within normal limits | RCT | |||
| 10. Childhood Wheezing | 1.3 times | RCT | ||
| 11. Additional child is Autistic | 4 times | Intervention | ||
| 12.Young adult Multiple Sclerosis | 1.9 times | Observe | ||
| 13. Preeclampsia in young adult | 3.5 times | RCT | ||
| 14. Good motor skills @ age 3 | 1.4 times | Observe | ||
| 15. Childhood Mite allergy | 5 times | RCT | ||
| 16. Childhood Respiratory Tract visits | 2.5 times | RCT | ||
RCT = Randomized Controlled Trial
Download the PDF from VitaminDWiki
It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM). The present randomized, double-blind placebo-controlled clinical trial was conducted on 133 pregnant women with GDM during weeks 24-28 of pregnancy. The patients were randomly divided into four groups. The control group (n=20) received a placebo (sucrose; one granule/day), the low dosage group (n=38) received the daily recommended intake of 200 IU vitamin D (calciferol) daily, the medium dosage group (n=38) received 50,000 IU monthly (2,000 IU daily for 25 days) and the high dosage group (n=37) received 50,000 IU every 2 weeks (4,000 IU daily for 12.5 days). The general characteristics and dietary intakes of the patients with GDM were similar between each group. Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P<0.05). Total antioxidant capacity and total glutathione levels were significantly elevated as a result of high dosage vitamin D supplementation (P<0.01). In conclusion, high-dose vitamin D supplementation (50,000 IU every 2 weeks) significantly improved insulin resistance in pregnant women with GDM.