The effects of vitamin D3 supplementation on some metabolic and inflammatory markers in diabetic nephropathy patients with marginal status of vitamin D: A randomized double blind placebo controlled clinical trial
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Vol13, Issue 1, Jan–Feb 2019, Pages 278-283, https://doi.org/10.1016/j.dsx.2018.09.013
Note: The trial lasted only 8 weeks
Can anticipate even better results for trials lasting 12-24 weeks
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
which also includes Diabetic Epidemic- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Kidney
- Every child with kidney problems (ideopathic nephrotic syndrome) had low vitamin D – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Diabetic Nephropathy – active vitamin D helps – Dec 2014
- Blacks have 4X more Kidney disease than whites – probably due to low vitamin D – March 2015
- Diabetic neuropathy least likely if have 30-40 ng of vitamin D – Oct 2015
Items in both categories Diabetes and Kidney are listed here
- DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D) – Feb 2024
- Magnesium Depletion Score predicts increased risk of various health problems
- Diabetics 5X more-likely to get CKD if have very low Vitamin D – June 2022
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Vitamin D deficiency associated with increased risk of many health problems in 58,000,000 Americans - Nov 2020
- Diabetic kidney problems in children last longer if low vitamin D – May 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Psoriasis is associated with kidney disease, heart problems, diabetes, etc – Nov 2015
- Diabetic Nephropathy – active vitamin D helps – Dec 2014
- Fructose reduces blood levels of active vitamin D
- Table of outcomes for seniors vs vitamin D level
- Vitamin D decreases incidence of disease
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetes category starts with the following
553 items In Diabetes category 34+ Prediabetes studies 64+ Type 1 Diabetes studies see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has204 items along with related searches
Images from the web
Download the PDF from VitaminDWiki
Metabolic and Inflammatory parameters.
Aims
Diabetic nephropathy is known to be an independent risk factor in the progression of renal and cardiovascular disorders. Due to the association between vitamin D deficiency and diabetic nephropathy, vitamin D deficiency in the diabetic nephropathy population, this study conducted to examine the effects of Vitamin D3 on metabolic and inflammatory parameters in patients with diabetic nephropathy.Methods
This eight-week, randomized, double-blind, placebo-controlled trial was carried out on 50 diabetic nephropathy patients with marginal status of vitamin D. Participants were randomly assigned to two groups: control and intervention. Participants received a vitamin D3 (50000 IU) supplement weekly on a specific day. Fasting blood samples were collected from all patients at their entry to the study, and eight weeks after intervention.Results
Analyses showed significance differences in physical activity between the intervention and placebo groups (P = 0.018). There were no significant differences between the percentage changes of HbA1c, insulin and, inflammatory parameters such as TNF-α and IL-6 (P > 0.05), while the percentage change of FBS was significantly higher in the placebo group compared to the treatment one (P < 0.0001). Lower levels of FBS (P < 0.0001), insulin (P < 0.069), HOMA-IR (P < 0.001), TNF-α (P< 0.002) and IL-6 (P < 0.037) were found after supplementation in treatment group. However, the phosphorous and protein percentage change in urine were lower (P = 0.07) and higher (P = 0.003) between groups.Conclusions
This page was renamed on Nov 2018. There have actually been
It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-α and IL-6.11450 visitors to this page since it was originally made
Study was cited by 23 later studies as of Aug 2022
Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019(Cached) Printer Friendly Follow this page for updates10948 visitors, last modified 20 Aug, 2022, This page is in the following categories (# of items in each category)Attached files
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