Vitamin D Plasma Levels and In-Hospital and 1-Year Outcomes in Acute Coronary Syndromes A Prospective Study
(Medicine 94(19):e857), DOI: 10.1097/MD.0000000000000857
Monica De Metrio, MD, Valentina Milazzo, MD, Mara Rubino, MD, Angelo Cabiati, MD,
Marco Moltrasio, MD, Ivana Marana, MD, Jeness Campodonico, MD, Nicola Cosentino, MD,
Fabrizio Veglia, PhD, Alice Bonomi, PhD, Marina Camera, PhD,
Elena Tremoli, PhD, and Giancarlo Marenzi, MD
Deficiency in 25-hydroxyvitamin D (25[OH]D), the main circulating form of vitamin D in blood, could be involved in the pathogenesis of acute coronary syndromes (ACS). To date, however, the possible prognostic relevance of 25 (OH)D deficiency in ACS patients remains poorly defined. The purpose of this prospective study was to assess the association between 25 (OH)D levels, at hospital admission, with in-hospital and 1-year morbidity and mortality in an unselected cohort of ACS patients.
We measured 25 (OH)D in 814 ACS patients at hospital presentation. Vitamin D serum levels >30ng/mL were considered as normal; levels between 29 and 21ng/mL were classified as insufficiency, and levels < 20ng/mL as deficiency. In-hospital and 1-year outcomes were evaluated according to 25 (OH)D level quartiles, using the lowest quartile as a reference.
Ninety-three (11%) patients had normal 25 (OH)D levels, whereas 155 (19%) and 566 (70%) had vitamin D insufficiency and deficiency, respectively. The median 25 (OH)D level was similar in ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) patients (14.1 [IQR 9.0-21.9] ng/mL and 14.05 [IQR 9.1-22.05] ng/mL, respectively; P — .88).The lowest quar- tile of 25 (OH)D was associated with a higher risk for several in-hospital complications, including mortality. At a median follow-up of 366 (IQR 364-379) days, the lowest quartile of 25 (OH)D, after adjustment for the main confounding factors, remained significantly associated to 1-year mortality (P < .01). Similar results were obtained when STEMI and NSTEMI patients were considered separately.
In ACS patients, severe vitamin D deficiency is independently associated with poor in-hospital and 1-year outcomes. Whether low vitamin D levels represent a risk marker or a risk factor in ACS remains to be elucidated.
 Download the PDF from VitaminDWiki
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
7961 visitors, last modified 27 Feb, 2017, |
ID | Name | Uploaded | Size | Downloads | |
---|---|---|---|---|---|
5800 | Event free survival.jpg | admin 13 Aug, 2015 | 14.99 Kb | 936 | |
5799 | ACS 1 year.jpg | admin 13 Aug, 2015 | 93.07 Kb | 1127 | |
5798 | ACS in hospital.jpg | admin 13 Aug, 2015 | 121.18 Kb | 1511 | |
5797 | ACS.pdf | admin 13 Aug, 2015 | 796.95 Kb | 782 |