Four Weeks of Preoperative Omega-3 Fatty Acids Reduce Liver Volume: a Randomised Controlled Trial
OBES SURG (2019). https://doi.org/10.1007/s11695-019-03814-7
Nathalie Bakker, Rick S. van den Helder Remy W. F. Geenen Michiel A. Hunfeld Huib A. Cense Ahmet Demirkiran Alexander P. J. Houdijk
- Vitamin D probably important for Bariatric Surgery – April 2018
- Bariatric surgery less than 30 ng of vitamin D – 82 pcnt teens, 100 pcnt of black teens – June 2012
- Prior to Bariatric Surgery 96 percent were vitamin D deficient – July 2014
- Hospital-Acquired Infections 3X more likely after Gastric Bypass if less than 30 ng vitamin D – Feb 2014
Founder of VitaminDWiki speculates that Omega-3 + Vitamin D would be great before Bariatric Surgery
Items in both categories Obesity and Omega-3 are listed here:
- Omega-3 added to father’s diet reduced offspring’s obesity (mice) – June 2024
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- 4 weeks of Omega-3 better than 2 week 800 calorie diet before Bariatric Surgery – RCT March 2019
- Omega-3 may reduce weight gain and maintain weight loss – Aug 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- How Omega-3 fights metabolic syndrome and weight – Feb 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Obese youths 2X less likely to develop Metabolic Syndrome if take Omega-3 – RCT April 2016
- Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016
- Huge increases in Omega-6 to Omega-3 ratio increase risk of obesity, etc. – March 2016
- Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
- Hypothesis – Omega-6 to Omega-3 ratio increases obesity – Nov 2015
- Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013
- Reasons for low response to vitamin D
Download the PDF from Sci-Hub via VitaminDWiki
Low Calorie Diet (LCD) was much harder on patients than Omgea-3
Purpose
Weight loss before bariatric surgery with a low-calorie diet (LCD) has several advantages, including reduction of liver volume and an improved access to the lesser sac. Disadvantages include performing surgery in a state of undernutrition, side effects, costs and patient compliance. Omega-3 fatty acids may serve as an alternative to reduce liver steatosis.
Materials and Methods
A randomised controlled open-label trial was done to compare the effects of a LCD with Modifast (800 kcal/day) during 2 weeks with 2 g of omega-3 fatty acids a day and a normal diet (2000 kcal/day) during 4 weeks. Total liver volume (TLV) and volume of the left liver lobe (LLL), visceral fat area (VFA) and muscle area (SMA) at the L3–L4 level were measured with MRI before and after preoperative treatment.
Results
Sixty-two morbidly obese women undergoing laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) were recruited. In both groups, there was a significant decrease in LLL, TLV and VFA. For LLL and TLV reduction, the LCD had a significantly larger effect (p < 0.05). Only in the LCD group was there a significant decrease in SMA with significantly more side effects and worse compliance.
Conclusion
Both the LCD and omega-3 diet reduced LLL, TLV and VFA. The LCD outperformed the omega-3 diet in LLL and TLV reduction, but induced significant loss of SMA and had worse compliance due to more side effects. Omega-3 fatty acids may provide a safe and more patient-friendly alternative for a LCD and further research is indicated.