Early puberty during pandemic (low vitamin D) - several studies

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Increase in early puberty during COVID: Italy 2.2X, China 6.2X, Brazil 1.5X - 2023

FROM PLAYGROUND TO PRECOCIOUS PUBERTY: HOW COVID-19 TURNED PUBERTY INTO A PANDEMIC, A MULTI-COUNTRY STUDY
 Download the PDF from VitaminDWiki

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Surges in Early Puberty Reported During COVID-19 Pandemic: Verified in Multiple Observational Studies - Sept 2022

TrialSiteNews
4 studies. Rate doubled in 2 of the studies

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Early puberty cases among girls surged during pandemic - April 2022

MDEdge no mention of lockdown ==> lower level of vitamin D

• "In another study, a Turkish pediatric endocrinology clinic reported 58 cases during the first year of the pandemic, as compared with 66 total cases during the 3 previous years."
• "Doctors have tied the current uptick to the stress of the pandemic and lockdowns, including reduced physical activity and increased consumption of unhealthy food, which are things linked to a higher risk of early puberty."

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Precocious Puberty and Covid-19 Into Perspective: Potential Increased Frequency, - Sept 2021

Possible Causes, and a Potential Emergency to Be Addressed
Front. Pediatr., 20 September 2021 https://doi.org/10.3389/fped.2021.734899
Maria E. Street1*, Chiara Sartori1, Cecilia Catellani1,2 and Beatrice Righi1
1Division of Pediatric Endocrinology and Diabetology, Unit of Pediatrics, Department of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
2PhD Program in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy

PDF Table of Contents

A significant increase in precocious puberty, rapidly progressive puberty and precocious menarche has been reported in Italy since the initial lockdown because of the pandemic, and this could represent a new emergency to be addressed during this pandemic. There is a need, therefore, for further understanding and research. Many causes could account for this. Initially, it was thought that the changes in life-style, in screen time, and sleeping habits could be the cause but if considered individually these are insufficient to explain this phenomenon. Likely, changes in central nervous mediators, and an increase in catecholamines could contribute as a trigger, however, these aspects are poorly studied and understood as well as the real perceptions of these children. Finally, staying more indoors has certainly exposed these children to specific contaminants working as endocrine disruptors which could also have had an effect. It would be of utmost importance to compare this phenomenon worldwide with appropriate studies in order to verify what is happening, and gain a new insight into the consequences of the covid-19 pandemic and into precocious puberty and for future prevention.
 Download the PDF from VitaminDWiki

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Note: COVID infection reduces both vitamin D in blood and Vitamin D in getting to the cells

• COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
• COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021

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VitaminDWiki - Early Puberty if low vitamin D - many studies

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Note: Vitamin D is reduced when outdoors less (during pandemic)

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VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

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VitaminDwiki COVID infections and vaccinations decrease Vitamin D – many studies

Vaccination

• COVID vaccinations resulted in big increase in metabolic disorders - Nov 2023
• COVID vaccination health problems - Campbell, Yale Nov 2023
• Hypothesis: Multiple COVID vaccinations reduce Vitamin D, resulting in Excess Deaths, etc. - Oct 2023
• Following COVID vaccination 31% had neurological problems (Italy) – Oct 2023
• Autoimmune diseases caused in first day after COVID Vaccination - Oct 2023
• Immune System tolerance is inversely related to the number of COVID vaccinations (PubMed analysis) - Oct 2023
• Hospital utilization Australia (NSW) 1415 Vaccinated, 0 unvaccinated - Dec 2022
• Vaccinated children have more health problems – any vaccination, not just COVID
• Multiple COVID vaccinations might increase Cancer Incidence - many studies
• Vaccine Clinical Trial - cardiovascular death 3.7X more likely if vaccinated - preprint Sept 2023
• Myocarditis, Pericarditis 2X more likely if had COVID vaccination in previous 30 days - meta-analysis June 2023
• COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
• 800x Higher Incidence of Myocardial Injury After Booster Vaccination - July 2023
• 74% of autopsies were found to be related to COVID vaccination (from 44 studies) – Lancet July 2023
• More psoriasis flares following second COVID vaccination if lowish Vitamin D – May 2023
• Long-COVID 2.2X more-likely if had 2 COVID vaccinations - Dec 2022

Vaccination and/or Infection

• COVID infections or vaccinations may increase Multiple Sclerosis (if low D) - several studies
• 50% increase in Cancer deaths (age 15-44) since before COVID - Nov 2023
• Early puberty during pandemic (low vitamin D) - several studies
• Excess deaths - 5 possible reasons - many studies
• Low heart rate variability (bad) is associated with low Vitamin D and COVID – many studies
• T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
• Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
• Increased risk of many neuro problems after COVID (1.4 X youths, 1.2X seniors) – Aug 2022
• COVID increased seniors risk of Alzheimer's by 1.7X in the next year- Sept 2022
• Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
• Athletes who had been COVID infected had lower Vitamin D levels – July 2023
• COVID, Vitamin D, Drs. Grimes and Campbell - Jan 2024 has the following chart

Hypothesis: The body consumes Vitamin D each time the immune system is activated

The "GREEN" person started with a high level of Vitamin D
This assumes no vitamin D supplementation by supplements, sun, etc.

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