Table of contents
- Association between serum 25 (OH) D levels and depression symptoms in adults with prediabetes
- Note: Diabetes lowers vitamin D; Depression is associated with low vitamin D
- Intervention of Vitamin D for Depression
- Meta-analyses of Vitamin D and Depression
- VitaminDWiki - Depression category contains
- VitaminDWiki -
12 studies in both categories Depression and Diabetes - VitaminDWiki -
28 studies in both categories Depression and Omega-3 - 3 related studies on the web
Association between serum 25 (OH) D levels and depression symptoms in adults with prediabetes
Diabetes Metab Syndr. 2022 Oct 13;16(11):102642. doi: 10.1016/j.dsx.2022.102642 pdf behind a paywell
Thi Quynh Chi Vu 1 , Quoc Kham Tran 2 , Kaijun Niu 3Background and aim: Depression symptoms are a significant risk factor for prediabetes-related diabetes, and low vitamin D levels are connected with depression symptoms. The goal of this study is to examine the association between vitamin D and depression symptoms in prediabetic persons.
Methods: This cross-sectional survey was conducted in Tianjin, China, among 4051 individuals. Symptoms of depression were assessed using the Self-Rating Depression Scale (SDS) (cut-off point SDS ≥45). Serum 25 (OH) D concentrations were determined using an enzyme immunoassay (OCTEIA 25-hydroxy Vitamin D, IDS Ltd, UK) and classified into three levels: 50 nmol/L, 50-75 nmol/L, and >75 nmol/L. The link between serum 25 (OH) D concentrations and depression symptoms in prediabetes was investigated using multiple logistic regression analysis. The models were adjusted for a variety of potential confounders.
Results: The prevalence of symptoms of depression in prediabetic adults was 14.2% (12.5% males and 16.4% females). After adjusting for potentially confounding variables, the odds ratios - ORs for symptoms of depression in women across serum 25 (OH) D levels were 1.00 (reference), 1.03 (0.57, 1.39), and 0.28 (0.12, 0.57), respectively (p = 0.0015). However, no statistically significant connection was discovered in males.
Conclusion: In women with prediabetes, we showed a substantial negative connection between serum 25 (OH) D levels and depressed symptoms. Vitamin D supplementation may be an effective way to decrease the risk of depression symptoms in women with prediabetes.
Note: Diabetes lowers vitamin D; Depression is associated with low vitamin D
Intervention of Vitamin D for Depression
- Depression cost-effectively reduced by 50,000 IU of Vitamin D monthly (Iranian teens) – July 2023
- Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023
- Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022
- Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case) – July 2021
- Depression in psychiatric youths reduced 28 percent after just 1 month of vitamin D – RCT Feb 2020
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D - no cure for depression (when you use only 1200 IU) – Aug 2019
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Women had better sexual desire, orgasm and satisfaction after Vitamin D supplementation – Feb 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013
- Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
Meta-analyses of Vitamin D and Depression
- Depression reduced by 8,000 IU of Vitamin D daily – meta-analysis Nov 2024
- Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
- Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Depression reduced if use more than 2,800 IU of vitamin D – meta-analysis Aug 2022
- Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses July 2022
- Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Depression is associated with low Magnesium – meta-analysis April 2015
- Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
- Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis – Nov 2014
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- Low vitamin D and depression - Study and meta-analysis, April 2013
- 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis Jan 2013
VitaminDWiki - Depression category contains
- Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
- Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
- Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
- Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Depression treated by Omega-3 (again) – meta-analysis Aug 2019
- Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
- Omega-3, Magnesium, and St. Johns' Wort also decrease depression
- Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
- Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
- Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
- There are
268 items in the Depression category in VitaminDWiki Some recent publications
- Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Post-partum depression and low Vitamin D - many studies
- Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
VitaminDWiki -
12 studies in both categories Depression and Diabetes This list is automatically updated
- Water-soluble form of vitamins are needed for some health problems
- Depression more likely if low vitamin D (3.5 X prediabetic women in this case) – Oct 2022
- Depression reduced in Diabetics with 3 months of 4,000 IU of vitamin D – RCT July 2019
- Depression twice as common in Diabetics (both have low vitamin D) – Aug 2018
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Depression 2X more common among diabetics, both associated with low vitamin D – 2014
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Hypothesis non-severe depression and diabetes related by low vitamin D – June 2011
- Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010
- Table of outcomes for seniors vs vitamin D level
VitaminDWiki -
28 studies in both categories Depression and Omega-3 This list is automatically updated
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021
- Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
- Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019
- Omega-3 helps treat Major Depression – International Consensus Sept 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018
- Depression treated by Omega-3 (again) – meta-analysis Aug 2019
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Occupational burnout reduced after 8 weeks of Omega-3 – RCT July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Psychotic disorders not treated by Omega-3 when patents take anti-depressants and get therapy – June 2018
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Omega-3 does not consistently treat depression if use small amounts for short time period – review Oct 2016
- How Omega-3 Fights Depression – LEF July 2016
- Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
- Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015
- Depression substantially decreased with Omega-3 – Sept 2015
- Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015
- Omega-3 prevents PTSD and some mood disorders - Aug 2015
- Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
3 related studies on the web
- Omega-3 supplementation and diabetes: A systematic review and meta-analysis - Jan 2021 https://doi.org/10.1080/10408398.2021.1875977 - $55 PDF
- Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial - Sept 2021 https://doi.org/10.1002/brb3.2342 FREE PDF
- The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review Dec 2018 https://doi.org/10.1016/j.jnim.2018.02.002 FREE PDF
Depression more likely if low vitamin D (3.5 X prediabetic women in this case) – Oct 2022Printer Friendly Follow this page for updates2176 visitors, last modified 25 Oct, 2022, This page is in the following categories (# of items in each category)
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