The clues for new roles of vitamin D and vitamin D receptor in neurodegeneration
Presented by E Dursan duygugezenak at gmail.com at Scientific Workshop
"Vitamin D, in the prevention of health disparities during adult life, mediterranean experts meeting"
Held on 30-31/8/2018, in Aristotle University Research Dissemination Center (KEDEA), in Thessaloniki, Greece,.
37 minute video
A few of the presented images
VDR Alz history
Subcellular location of VDR
Plaque and Vitamin D (arrows added by VitaminDWiki)
Hypothesis 1 and 2
Download the PDF from VitaminDWiki
Download the PowerPoint from VitaminDWiki
This is one of 19 videos from the workshop
Overview Alzheimer's-Cognition and Vitamin D in VitaminDWiki has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home. $75/month.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
Items in both VitaminDWiki categories Cognition and Vitamin D Receptor are listed here:
- Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022
- Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022
- 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
- Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- Resveratrol for Alzheimer's disease – Sept 2017
- Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Body may change gene activation if more Vitamin D is needed (Schizophrenia in this case) – Oct 2018
- Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012
See also VitaminDWiki
- The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
- Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013
- Alzheimer's disease – less risk if smarter, higher vitamin D, better genes or less coffee – Dec 2017
- Alzheimer's disease most likely will need more than monotherapy such as vitamin D – May 2013
- Poor Cognition and Alzheimer’s Disease both associated with low vitamin D – review May 2015
- Alzheimer disease 5X less likely with nonmelanoma skin cancer (lots of vitamin D) – May 2013
- Hypothesis – Alzheimer’s Disease results of hormone imbalance (vitamin D etc.) – Jan 2014
- Decrease of Alzheimer’s biomarker halted by Resveratrol (perhaps due to vitamin D) – RCT Sept 2015
- Note: Resveratrol is also important in several other vitamin D related diseases
- Why vitamin D in Alzheimer's disease - a hypothesis – Jan 2014 very interesting
- DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014
See VitaminDWiki DDT and other pesticides decrease vitamin D - Variety of evidence that Vitamin D helps the brain – July 2014 has the following chart
Presentations
- Molecular genetics and vitamin D action E. Kassi
- Vitamin D and human reproduction D. Goulis
- Effects of Vitamin D supplements and osteoporosis treatment on musculoskeletal system A. Bargiotta
- Optimizing Vitamin D status in children with pre - school wheeze or asthma: a pilot study (OptiVit) Ch. Stefanidis
- Molecular background of Vitamin D anticancer action: Impact on hypoxia inducible transcription factors (HIFs) A. Tsakalof
- Preoperative serum Vitamin D levels in patients with breast cancer is associated with histological characteristics of the tumor G. Panagiotou
- Prevalence of Vitamin D deficiency in a Greek and a Cypriot population sample S.-E. Xyda
- The relationship between Vitamin D and MTDNA encoded genes expression M. Alaylioglu
- Association of CUBN gene variants with type 2 diabetes mellitus and Vitamin D levels in an elderly Greek Population X. Tsekmekidou
- Vitamin D and cancer W. B. Grant
- Management of vitamin D deficiency: Guidelines of the Hellenic Endocrine Society K. Kotsa, S.-N. Karras
- The clues for new roles of vitamin D and vitamin D receptor in neurodegeneration E. Dursun, D. Gezen - Ak
- Vitamin D and Pregnancy A.-M. Michailidou
- Osteoporosis Markers Among Emirati Females Based on Vitamin D
- Receptor Variants and Biomechanical Parameters F. Al. Anouti
- Regulation of Parathyroid Hormone secretion in normal subjects S. Minisola
- Quantification of 25-Hydroxyvitamind3/D2 by UHPLC-DAD with online metabolites isolation and preconcentration A. Tsakalof
- Vitamin D and cognitive function in older adults: a review of the literature N. Syrmos
- The role of Vitamin D in Atopic Dermatitis V.-E. Pappa
- Anxiety and Depression is associated with decreased Vitamin D levels in an elderly population in Northern Greece D. Drivakou
- Measurement of vitamin D metabolites - Assays Naughton
- Vitamin D and Nutrition (Food fortification - Optimizing Vitamin D status in the Mediterranean region-a global perspective) Kotzakioulafi
- Vitamin D and obesity S. Tigas
- Vitamin D supplementation in clinical practice: a practical approach T. Koufakis, E. Rapti
On VitaminDWiki Vitamin D dosing - weekly may be better than daily – video Aug 2018