Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022

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Recent advances in vitamin D implications in chronic respiratory diseases

Respir Res. 2022 Sep 19;23(1):252. doi:10.1186/s12931-022-02147-x
Mellissa Gaudet 1 , Maria Plesa 1 , Andrea Mogas 1 , Nour Jalaleddine 2 , Qutayba Hamid 3 4 , Saba Al Heialy 5 6

PDF Table of Contents

Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been shown to be highly prevalent in patients with chronic airway inflammatory and infectious diseases, correlated with increased disease severity. It has been established that vitamin D modulates ongoing abnormal immune responses in chronic respiratory diseases and is shown to restrict bacterial and viral colonization into the lungs. On the contrary, other studies revealed controversy findings regarding vitamin D efficacy in respiratory diseases. This review aims to update the current evidence regarding the role of vitamin D in airway inflammation and in various respiratory diseases. A comprehensive search of the last five years of literature was conducted using MEDLINE and non-MEDLINE PubMed databases, Ovid MEDLINE, SCOPUS-Elsevier, and data from in vitro and in vivo experiments, including clinical studies. This review highlights the importance of understanding the full range of implications that vitamin D may have on lung inflammation, infection, and disease severity in the context of chronic respiratory diseases.
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VitaminDWiki - 12 studies in both categories Breathing and Immunity

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VitaminDWiki - 6 studies in both categories Breathing and Magnesium

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VitaminDWiki - Breathing category contains

454 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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VitaminDWiki - Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • Probably need gut-friendly Vitamin D
• CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on the chart to see the study

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VitaminDWiki - Cystic Fibrosis category contains

52 Cystic Fibrosis items     Highlights

• Cystic Fibrosis patients have low vitamin D (need different dosing) – meta-analysis Jan 2024
• Cystic Fibrosis appears associated with poor Vitamin D genes (radioactive tracing) – May 2023
• Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022
• Cystic Fibrosis is safely treated by high-dose Vitamin D – Sept 2019
• Cystic Fibrosis patients need different forms of Vitamin D – Nov 2021
• Cystic Fibrosis probably treated by Vitamin D (if use enough of the right type ) – Oct 2019
• Cystic Fibrosis helped in many ways by Vitamin K – July 2019
• Cystic Fibrosis vitamin D recommendations are not enough - Dec 2021
• Half of Cystic Fibrosis patients have low Magnesium levels – April 2022
• Powder-based Vitamin D may be gut-friendly (Cystic Fibrosis) – RCT Aug 2017
• Inhaled Vitamin D looks like a possibility for CF - VitaminDWiki

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VitaminDWiki - COPD Overview contains

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VitaminDWiki - 5 related items

• Inhaled vitamin D help lungs - many studies
• Overview Lung cancer and vitamin D
• Overview Tuberculosis and Vitamin D
• Pneumonia and low vitamin D - many studies
• Inflammation

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Vitamin D meta-analyses of Virus 44 studies

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VitaminDWiki - 25 studies in both categories Breathing and Virus

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PDF references

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