Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women
PLoS ONE 8(3): e57967. doi:10.1371/journal.pone.0057967
Dhruva K. Mishra, Yanyuan Wu, Marianna Sarkissyan, Suren Sarkissyan, Zujian Chen, Xiying Shang, May Ong, David Heber, H. Phillip Koeffler, Jaydutt V. Vadgama
Background: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among African-Americans and Hispanics. This study examines whether VDR gene polymorphisms are associated with breast cancer in these cohorts.
Methods: Blood was collected from 232 breast cancer patients (Cases) and 349 non-cancer subjects (Controls).
Genotyping for four polymorphic variants of VDR (FokI, BsmI, TaqI and ApaI) was performed using the PCR-RFLP method.
Results: An increased association of the VDR-Fok1 f allele with breast cancer was observed in African-Americans (OR = 1.9, p = 0.07). Furthermore, the FbTA, FbtA and fbtA haplotypes were associated with breast cancer among African-Americans (p<0.05). Latinas were more likely to have the VDR-ApaI alleles (Aa or aa) (p = 0.008). The VDR-ApaI aa genotype was significantly associated with poorly-differentiated breast tumors (p = 0.04) in combined Cases. Kaplan-Meier survival analysis showed decreased 5-year disease-free-survival (DFS) in breast cancer patients who had the VDR-Fok1 FF genotype (p<0.05). The Cox regression with multivariate analysis revealed the independent predictor value of the VDR-FokI polymorphism for DFS. The other three variants of VDR (BsmI, TaqI and ApaI) were not associated with disease outcome.
Conclusions: VDR haplotypes are associated with breast cancer in African-Americans, but not in Hispanic/Latinas.
The VDR-FokI FF genotype is linked with poor prognosis in African-American women with breast cancer.
Received: November 5, 2012; Accepted: January 29, 2013; Published: March 12, 2013
Funding: This work was supported by National Institutes of Health(NIH)/NCI (Grant numbers U56CA101599-01; CA15083-25S3; U54CA14393); NIH/NIDDK (Grant number R25DK067015-01); Department of Defense (BCRP) (Grant number BC043180) – to JVV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Far more women died of breast cancer with these altered genes
Note: more graphs in the PDF
PDF is attached at the bottom of this page
Suspect that Caucasian women with these VDR genes would need more vitamin D in blood stream to prevent breast cancer.
See also VitaminDWiki
- Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- All items in category Breast Cancer and Vitamin D
259 items - Overview Breast Cancer and Vitamin D
Items in both categories Breast Cancer and Vitamin D Receptor are listed here:
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- Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022
- Some breast cancers may be treated RNA changes caused by Vitamin D – March 2022
- Breast Cancer, Vitamin D, and genes – Welsh Nov 2021
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021
- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Genes breast cancer and vitamin D receptor - Sept 2010
Vitamin D receptor in breasts and breast cancer vary with race – March 2013Printer Friendly Follow this page for updates9322 visitors, last modified 07 Dec, 2019, This page is in the following categories (# of items in each category)