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Vitamin D may reduce autism by increasing nitric oxide – June 2022


A Probable Way Vitamin D Affects Autism Spectrum Disorder: The Nitric Oxide Signaling Pathway

Front Psychiatry. 2022 May 26;13:908895. doi: 10.3389/fpsyt.2022.908895
Bing Wang 1 2, HanYu Dong 2, HongHua Li 2, XiaoJing Yue 2, Lin Xie 1

Study Table of Contents

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Vitamin D (VD) deficiency during pregnancy and early brain development is an important environmental risk factor for autism spectrum disorder (ASD). Its specific mechanism of action is still unclear. However, one study on the correlation between metabolomics and VD levels in children with ASD has found that the whole-blood arginine (Arg) levels of children with ASD are significantly negatively correlated with serum VD levels, suggesting that the effect of VD on ASD may be related to the signaling pathway involving Arg. Arg is a precursor of nitric oxide (NO), and changes in its levels most directly affect NO levels and signal transduction pathways. NO, a biologically active free radical, is both a neurotransmitter and a neuromodulator in the central nervous system and is related to the pathogeneses of various neurological diseases. The NO signaling pathway is not only affected by VD levels but also closely related to ASD through a series of mechanisms, such as neurotransmitter imbalance, immune disorders, and oxidative stress. Therefore, the effect of VD on ASD may be achieved via regulation of the NO signaling pathway. The current review discusses the relationship among VD, NO, and ASD as suggested by a large body of evidence in the literature in an effort to provide clues for researchers on the pathogenesis of ASD and the mechanism of VD's impact on ASD.
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In addition, NO can inversely regulate 1,25(OH)2D levels. CYP27B1 is a 1a hydroxylase gene whose expression is bidirectionally regulated by NO levels. The transcription of CYP27B1 can be upregulated at low concentrations of NO but inhibited by high concentrations of NO, thereby further affecting the levels of 1,25(OH)2D (81). Therefore, VD levels are closely related to NO levels, and the two influence each other.
CONCLUSIONS
VD deficiency during pregnancy and early brain development is an important environmental risk factor for ASD, and highdose VD can improve the core symptoms of ASD. The serum VD levels in children with ASD are significantly negatively correlated with the levels of the raw material for NO synthesis, Arg. NO, one of the most important signaling molecules in the brain, is involved in the occurrence of various brain- related diseases and is an important pathological molecule in ASD, Its role in ASD is mediated by a series of mechanisms, such as neurotransmitter imbalance, immune disorders, and oxidative stress. VD can regulate the levels of molecules in the NO signaling pathway. This review hypothesizes a potential mechanism in which abnormal levels of NO during the critical period of brain development caused by various factors (including abnormalities in neurotransmitters, immune disorders, etc.) are important factors in the pathogenesis of ASD, and VD affects the pathogenesis and severity of ASD by regulating NO levels. If this hypothesis is verified, monitoring NO levels during pregnancy and early brain development may become an important strategy for ASD risk prediction, and NO levels may guide the timing and dosing of VD supplementation. Researches on this pathway could contribute to detect more objective criteria for the diagnosis of ASD. The combination of VD and NO- related issues might indicate possible subtype of ASD. Eventually this may lead to more effective prevention and treatment of ASD.


Nitric Oxide INCREASED Austism in mice - Israel May 2023

Trial Site News


VitaminDWiki - CYP27B1 category contains

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
Poor CYP27B1 is assocated with COVID, Miscarriage,   Lupus,   Alz, Parkinson, MSA,   Rickets

CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

What can be done if have a poor CYP27B1

  • Larger doses of Vitamin D
  • More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
  • Additional sources: UV
  • Increase Vitamin D metabolism: additional Magnesium, Omega-3
    • All cytochrome P450 enzymes require Mg++ as a cofactor
  • Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR

Vitamin D blood test misses CYP27B1 and other genes
in Visio for 2023


12+ VitaminDWiki pages with NITRIC OXIDE in the title

This list is automatically updated

Items found: 15
Title Modified
Plant Nitrates decrease mortality, other Nitrates increase mortality (Nitric Oxide) - May 2024 05 Aug, 2024
Embrace the Sun – benefits of the sun (Nitric Oxide etc.) – book June 2018 05 Aug, 2024
Sunlight and UVB provide a few more health benefits than Vitamin D (Nitric Oxide, etc.) – Weller April 2024 26 Apr, 2024
UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide – Sept 2023 21 Sep, 2023
Nitric oxide (from sun, Mg, Vit D, etc) reduces some health problems - many studies. 21 Oct, 2022
Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022 27 Jun, 2022
Vitamin D may reduce autism by increasing nitric oxide – June 2022 20 Jun, 2022
Inhaling Nitric Oxide 4 times a day (which increases Vitamin D) fights COVID - May 2022 13 May, 2022
Nitric oxide (from Sun, UVA, Vitamin D) reduces cardiovascular problems 30 Apr, 2022
Nitric oxide increased by UVA, Vitamin D, Magnesium, etc, 29 Apr, 2022
Off topic: Low Level Laser Therapy works - makes Nitric Oxide and ATP 25 Mar, 2022
Sweating (sunbathing, intense exercise, sauna) removes toxins and increases Nitric Oxide 28 Sep, 2018
Heart cells may be repaired by vitamin D (nanosensors observed nitric oxide in dish) - Jan 2018 01 Feb, 2018
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
UV (perhaps Nitric Oxide) better than vitamin D at preventing obesity in rats on a high-fat diet – Nov 2014 31 Dec, 2014

VitaminDWiki - Autism category contains

Autism category has 165 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

Autism TREATED by Vitamin D

Autism PREVENTED by vitamins before and during pregnancy

Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated

Autism - other risk factors

6 Autism and Virus/Vaccines

Dr. Cannell on Autism and Vitamin D in VitaminDWiki

7 studies: Autism reduced by Omega-3

Created by admin. Last Modification: Friday September 22, 2023 13:24:51 GMT-0000 by admin. (Version 9)
Vitamin D may reduce autism by increasing nitric oxide – June 2022        
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17920 NO and autism.jpg admin 20 Jun, 2022 28.63 Kb 429
17919 Nitric Oxide autism.pdf admin 20 Jun, 2022 424.52 Kb 165