Guesses of Vitamin D response if poor gut
Bio | Form | Speed | Duration |
10 | Injection ($$$) or Calcidiol or Calcitriol | D - Slow C -Fast | Long |
10 | Sun/UVB | Slow | Long |
10 | Topical (skin patch/cream, vagina) | Slow Fast nano | Normal |
9 | Nanoemulsion -mucosal perhaps activates VDR | Fast | Normal |
9? | Inhaled (future) | Fast | Normal |
8 | Bio-D-Mulsion Forte | Normal | Normal |
6 | Water soluble (Bio-Tech) | Normal | Normal |
4 | Sublingual/spray (some goes into gut) | Fast | Normal |
3 | Coconut oil based | Slow | Normal |
2 | Food (salmon etc.) | Slow | Normal |
2 | Olive oil based (majority) | Slow | Normal |
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
Poor gut is associated with Gut diseases as well as Diabetes, Multiple Sclerosis, and many other diseases
Reminder - Vitamin D is absorbed in the first portion of the small intestine
Some gut problems which only occur in large intestine may not be a problem
On-going research at VitaminDWiki as of March 2017
Getting Vitamin D into your body has details on each thype of vitamin D and the following chart
Parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with type 2 diabetes mellitus
Diabetes & Metabolic Syndrome: Clinical Research & Reviews. online 6 March 2017, http://dx.doi.org/10.1016/j.dsx.2017.03.019
Awanindra Dwivedia, Balram Guptaa, Shalbha Tiwaria, d, Daliparthy D. Pratyusha, d, Saurabh Singhc, Surya Kumar Singha, sksendocrine at yahoo.com
Almost 2X higher vitamin D level @ 30 days with injection
- Injection category listing has
65 items along with related searches - Overview Gut and vitamin D
- Gut-Friendly forms of vitamin D include bio-emulsion, topical, injection
- Inhaled vitamin D might be as good as injected (future)
Items in both of the categories Diabetes and VitaminD Injection are listed here:
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Neuropathy - 5X more had a good Quality of Life after 600,000 IU of Vitamin D - 2017
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
Background/objectives
Oral vitamin D supplementation is better than parenteral in improving vitamin D deficiency in individuals with no systemic illness. Our aim was to compare the efficacy of oral and parenteral routes of vitamin D supplementation on circulating serum 25(OH) vitamin D level in patients with type 2 diabetes mellitus.Methods
Total 85 cases of with type 2 diabetes mellitus were screened for vitamin D status of which 71 patients were vitamin D insufficient/deficient. They were randomized into two intent to treat groups with different vitamin D supplementation protocols- (a) Oral-60000 IU per day for 5 days (group I; n = 40) and
- (b) injectable-300000 IU intramuscularly once (group II; n = 31).
Baseline and one-month post supplementation 25(OH) vitamin D levels were measured in both the groups.
Results
Baseline clinical characteristics and 25(OH) vitamin D levels were comparable in both the groups. Post treatment 25(OH) vitamin D level in- group I was 26.06 ± 9.06 ng/ml and in
- group II was 49.69 ± 18.92 ng/ml.
After one month of vitamin D supplementation, increment in 25(OH) vitamin D level from baseline was significantly higher in group II than group I (p < 0.001).
Interpretation & conclusions
Injectable method of supplementation was better than oral route in improving serum 25 (OH) vitamin D status in patients with type 2 diabetes. The study suggested impaired absorption of vitamin D from the gastrointestinal tract in patients with type 2 diabetes mellitus and a need for parenteral route of vitamin D supplementation in deficient patients with type 2 diabetes mellitus.Publisher wants $31.50 for the PDF
Purchased by VitaminDWiki
Injection references in the study
- Comparison of oral versus injectable vitamin-D for the treatment of nutritional vitamin-D deficiency rickets July 2009
"injectable form was shown to be statistically significant" Can request full text at ResearchGate - Treatment of Hypovitaminosis D With Pharmacologic Doses of Cholecalciferol, Oral vs Intramuscular Medscape 2013
full text online, RCT, no difference for people without digestive problems
 Download the PDF from VitaminDWiki - A Randomized controlled trial on safety and efficacy of single intramuscular versus staggered oral dose of 600 000IU Vitamin D in treatment of nutritional rickets. Jun 2014  Download the PDF from VitaminDWiki
Bone Mineral Density - oral vs injection -Oct 2015
- Full text online. 10 weeks of 60,000 IU vs 1 600,000 IU injection + daily 1 gram of Calcium
"Although, with intramuscular route the serum vitamin D levels are maintained for 12 months, there is no improvement in BMD byeither route."
Sufficiency (> 30 ng) at 12 month:s 85.7% injection, 22.9%. oral
Short URL = is.gd/BioFormsVitamin D injection is far better than oral for diabetics (poor gut) – RCT March 201721931 visitors, last modified 01 Sep, 2020, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 7835 BMD inection.jpg admin 15 Mar, 2017 52.53 Kb 8816 7834 Injection RCT 2013.pdf admin 15 Mar, 2017 270.75 Kb 1354 7833 Injection rickets 2014.pdf admin 15 Mar, 2017 205.30 Kb 1147 7832 Rickets Injection 2014.jpg admin 15 Mar, 2017 39.52 Kb 4793