Loading...

Toggle Health Problems and D

Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019

VitaminDWiki Summary

Vitamin D may be able to treat many multidrug-resistant diseases
Cells which pump drugs out of them have the protein MRP1
Calcitriol kills cells with MRP1 (in Petrie dish)
This may be the reason that Vitamin D helps Chemo, etc.

How vitamin D helps fight treatment-resistant cancer Medical News Today

“The researchers showed that calcitriol and calcipotriol can selectively hone in on cancer cells that have too much MRP1 and destroy them”
“… multidrug resistance-associated protein 1 (MRP1). The protein sits in the cell wall and drives a pump that ejects cancer drugs out of the cell.”
“Cancer cells that develop resistance to chemotherapy drugs often overexpress, or overproduce, transporter proteins. This abundance is the primary cause of chemoresistance”
“MRP1 doesn't just reduce the effectiveness of cancer drugs, it can also weaken the effect of antibiotics, antivirals, anti-inflammatories, antidepressants, and drugs that treat HIV.”

Reference

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram
Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
Download the PDF from VitaminDWiki

VitaminDWiki

MRP1 connection may explain many of the following

Calcitriol in VitaminDWiki

Calcitriol category listing has 62 items along with related searches
Active vitamin D appears to treat cancer – more studies needed – June 2018

Quick Chemo look on the web

Known	Half of late-stage cancer patients get chemotherapy
Unknown	% of Cancers which are now Chemo resistant

Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019

5717 visitors, last modified 20 Jun, 2019,

Printer Friendly Follow this page for updates

Links to this page
- Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018 Chemotherapy might be augmented with Vitamin D – Jan 2017 Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017 Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018

This page is in the following categories (# of items in each category)

Cancer - after diagnosis 108 Top news 911

Edit Files 1

Attached files

ID	Name	Comment	Uploaded	Size	Downloads
12162	Calcitriol MRP1.pdf	PDF 2018	admin 19 Jun, 2019	1.13 Mb	648

“One pill every two weeks fights diabetes, cancers, heart failure, and 21 other diseases.”

Click for details

Health Problems and D

15,500+ pages in VitaminDWiki
Topic (# in topic)

Acne (20+ studies)

Attention Deficit Hyperactivity Disorder/ADHD (52+)

Alcohol (29+)

Allergy (120+) Overview

Amyotrophic Lateral Sclerosis/ALS (30+)

Alzheimer's (81+) Overview

Ankylosing Spondylitis (20+)

Antibiotics/Probiotics (92+) Overview

Asthma (145+) Overview

Atopic Dermatitis Overview (18+)

Autism (163) Overview

Vit. D Receptor (14+)

Transgender (19+)

Autoimmune (204+)

Systemic Sclerosis (10+)

Back Pain (44+)

Lumbar Degeneration (14+)

Bipolar Disorder (16+)

Bone - Health (313+)

BMD, Bone loss (55+)

Breathing (453+)

Hay Fever (20+)

Pneumonia (50+)

Respiratory (82+)

Burns/Wounds (30+)

Cancer (293+) Overview

After diagnosis (113+)

Bladder (28+)

Bone (8+)

Breast (259+) Overview

Child (16+)

Colon (145+) Overview

Endometrial (5+)

Gastric (9+)

Leukemia (19+)

Liver (17+)

Lung (55+) Overview

Lymphoma (26+)

Mg and Cancer (13+)

Melanoma (43+)

Multiple Myeloma (10+)

Metastatic (17+)

Other (66+)

Ovarian (26+)

Palliative Care (10+)

Pancreatic (58+)

Prostate (103+) Overview

Skin (121+) Overview

Survive (37+)

Thyroid (7+)

Cardiovascular (529+) Overview

Atherosclerosis (56+)

Atrial Fibrillation (20+)

Heart Failure (47+)

HRV (10+)

Omega-3 (38+)

Statins (80+)

Carpal Tunnel Syndrome (12+)

Cerebral Palsy (6+)

Cholesterol (52+) Overview

Chronic Fatigue (7) Overview

Cognitive (389+) Overview

Anesthesia ==> Cog

Brain (103+)

Delirium (9+)

Dementia (50+)

Mental Illness (300+)

Mental Stress (10+)

Colds/flu Overview

Concussions (25+)

Chronic obstructive pulmonary disease/COPD (17+)

COVID-19 (1300+)

Cystic Fibrosis (52+)

Dental (116+)

Fluoridation (16)

Periodontitis (32+)

Depression (268+)

Anxiety ( 11+)

Omega-3 (29)

SAD (9)

Diabetes (551+) Overview

Hemodialysis (41+)

Magnesium (27+)

Meta-analyses (39+)

Metabolic Syndrome + Mg

Neuropathy (15+)

Prediabetes (30+)

Red Meat (4+)

Retinopathy (8+)

Type 1 Diabetes (46+)

Vitamin D Receptor (23+)

Zinc (5+)

Diseases general (93+)

Ear (17+)

Otitis Media (10+)

Endometriosis (8+)

Falls/Fractures (258+) Overview

Fatigue, Chronic Overview

Fertility/Sperm (142+)

Erectile Dysfunction (12+)

In Vitro Fert. (18+)

Testosterone (14+)

Fibromyalgia Overview

Fractures Overview

Ankle (16+)

Bone & Stress Fractures

Bone Mineral Density (28+)

Children (16+)

Hip Fractures (68+)

Vertigo (22+)

Genetics (343+)

CYP24A1 (31+)

CYP24R1 (25+)

CYP27B1 (62+)

Epigenetics (18+)

Telomere (12+)

Vit D Binding (177+)

Vit D Receptor (517+)

Cancer in VDR (79+)

Gestational Diabetes (34+)

Gout (13+)

Gut (207+) Overview

Bariatric (15+)

Celiac (7+)

Clostridium difficile (9+)

Crohn's (38+)

IBD (28+)

IBS (18+)

Ulcerative Colitis (12+)

Hair (20+)

Alopecia Areata (8+)

Health - general (109+)

Human Immunodeficiency Virus/HIV (45+) Overview

Hives (10+)

Hypertension (165+) Overview

Pregnancy (41+)

Hyperparathyroid Overview

Immunity (273+)

Inflammation (175+)

CRP (19+)

Infection (141+)

Influenza Overview

Kidney (230+) Overview

Chronic Kidney (63+)

Dialysis (39+)

Kidney Stones (29+) Overview

Leprosy (16+)

Liver (102+) Overview

Hepatitis-B (12+)

Hepatitis-C (13+)

NAFLD (27+)

Lyme Disease (9+)

Lupus (78+)

Mental Illness (20+)

Mental Stress (5+)

Metabolic Syndrome (106+) Overview

Mortality (296+)

Multiple Sclerosis (412+) Overview

Genetics and Receptor (32+)

Virus (16+)

Muscle (113+)

Handgrip (12+)

Sarcopenia (30+)

Muscular Dystrophy (9+)

Myopia (17+)

Obesity (442+)Overview

Child & Youth (60+)

Vitamin D Receptor (16+)

Virus and Obesity (25+)

Weight Loss (31+)

Osteoarthritis (61+) Overview

Knee (26+)

Osteoporosis (220+) Overview

BMD (26+)

Pain - chronic (167+) Overview

Magnesium (13+)

Pancreatitis (20+)

Parkinson's (117+) Overview

Pneumonia (22+)

Pollution (31+)

Pregnancy (920+) Overview

Breastfed (38+)

Caesarean (15+)

Depression (21+)

Dark Skin (30+)

Gestational Diabetes (41+)

In Vitro Fert. (20+)

Iodine (28+)

Low Birth Weight (23+)

Magnesium (30+)

Miscarriage (38+)

Multiple Sclerosis (13+)

Omega-3 before and during (49+)

PCOS (15+)

Preeclampsia (63+)

Preterm (156+)

Preterm - Omega-3 (13+)

Stillbirth (12+)

Prostate - BPH (16+)

Psoriasis (72+)

Respiratory Tract Infection/RTI (8+)

Restless Legs Syndrome (15+)

Rheumatoid Arthritis (117+) Overview

Juvenile RA (9+)

Rickets (127+) Overview

Sarcopenia (28+)

Schizophrenia Overview

Sepsis (201+)

Sickle Cell (20+) Overview

Skin (122+) Overview

Aging

Atopic Dermatitis(27+)

Hives

Vitiligo (8+)

Sleep (101+)

Sleep Apnea(12+)

Smoking (83+)

Spinal Cord (21+)

Spinal Surgery (13+)

Statins (40+)

Stroke (131+) Overview

Cognitive Impairment (15+)

Depression (9+)

Ischemic (21+)

Thyroid/Parath. (82+) Overview

PTH (34+)

Trauma/Surgery (352+)

Bariatric surgery (12+)

Bone surgery (23+)

ICU & Loading Dose (69+)

Need Vit D (69+)

Ortho. & Hip (69+)

Sepsis (41+)

Transplant (31+)

Traumatic Brain Injury (24+)

Tuberculosis (125+) Overview

Urinary Tract Infection (15+)

Virus (1400+)

All studies

Bird Flu

Cardiovascular (19+)

Cancers after VAX (17+)

Child - years after VAX (11+)

Cognitive (10+)

Dengue (27+)

Epstein-Barr Virus (20+)

Excess Deaths (23+)

Hepatitis (29+)

Herpes or Shingles (13+)

Ivermectin (35+)

Long-COVID (72+)

Magnesium (60+)

Masks (11+)

Meta-analyses (40+)

Omega-3 (14+)

Pfizer (20+)

RSV (12+)

Ultraviolet light (16+)

Vaccination (198+)

Vitamin D (650+)

Vitamin D Receptor (31+)

Vitamin K

Zinc (32+)

Vision (112+)

Cataracts (13+)

Diabetic Retinopathy (8+)

Dry Eye (12+)

Glaucoma (8+)

Macular Degeneration (20+)

Myopia (20+)

Uveitis (10+)

People and Low Vitamin D

Infant/Child (854+)

Allergy (36+)

Cancer (13+)

Cerebral Palsy (15+)

Down Syndrome (5+)

Fracture, low energy (10+)

Growing Pains (10+)

Pneumonia (25+)

Preemie (25+)

Puberty early if low D (9+)

Respiratory (21+)

RSV (25+)

Tonsils (9+)

Vaccination (10+)

Virus (42+)

Military (27+)

Veterans (17+)

Prisoners (14+)

Seniors (430+) Overview

Aging (38+)

Essential Tremor (4+)

Frailty (20+)

Longevity (47+)

Nursing Homes (19+)

Sarcopenia (25+)

Urinary incontinence (15+)

Vertigo (22+)

Skin - Dark (460+) Overview

Pregnancies (30+)

Sports (277+) Overview

Exercise (68+)

Muscle (138+)

Traumatic Brain Inj. (24+)

Women (196+) Overview

Endometriosis (25+)

Incontinence (16+)

Menopause (17+)

PCOS

Premenstrual Syndrome (20+)

Uterine Fibroid (13+)

Yeast Infection

Youth (175+)

Early Puberty (15+)

Locations

World (14+)

Aust NZ (68+)

Africa (28+)

Europe (233+)

India (65+)

Iceland (40+)

Middle East (154+)

Orient (77+)

Russia (12+)

Scotland (20+)

Far from Equator (124+)

Click here to search the site
A list includes 290+ pages having many studies
# of studies as of Dec 11, 2024
short URL for this page = is.gd/dhealth