Vitamin D and clinical cancer outcomes: a review of meta analyses
John D Sluyter1, JoAnn E Manson2 3, Robert Scragg1
- 1 School of Population Health, University of Auckland, Private Bag,Auckland, New Zealand.
- 2 department of Medicine, Brigham and Womens Hospital, and Harvard Medical School, Boston, MA, USA.
- 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA USA
- Correspondence: Dr John Sluyter, School of Population Health, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. i.sluvter at auckland.ac.nz
Overview Breast Cancer and Vitamin D contains the following summary and sections
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25 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
259 items along with related searches - Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Vitamin D both prevents and treats Breast Cancer – 2019
Cancer category starts with the following- Cancer
295 items Overview Cancer and vitamin D - Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 items - Bladder Cancer
28 items - Breast Cancer
259 items Overview Breast Cancer and Vitamin D - Colon Cancer
145 items Overview Cancer-Colon and vitamin D - Leukemia
19 items - Liver Cancer
17 items - Lung Cancer
55 items Overview Lung cancer and vitamin D - Lymphoma Cancer
26 items - Other Cancer
66 items - Ovarian Cancer
26 items - Pancreatic Cancer
58 items - Prostate Cancer
103 items Overview Prostate Cancer and Vitamin D - Skin Cancer
121 items Overview Suntan, melanoma and vitamin D - Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
24 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
Cancer - Colon category starts with the following- Cancer - Colon category listing has
145 items - 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- 25+ Colon Cancer meta-analyses
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Cancer - After diagnosis category listing has
113 items along with related searches - see also:
Overview Cancer-Colon and vitamin D. Overview Cancer and vitamin D Overview Gut and vitamin D Cancer and Vitamin D - many studies
Pancreatic Cancer trials using Vitamin D and viral therapy – Nov 2018 contains the following- Pancreatic Cancer Survival 40 percent more likely if had adequate vitamin D (30 ng) – June 2016
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017
- Pancreatic Cancer stabilized by a woman taking 50,000 IU of vitamin D daily - 2016
Omega-3 helps
- Pancreatic Cancer is increasing – Vitamin D and Omega-3 should reduce the risk
- Severe acute pancreatitis treated in 11 ways by Omega-3 in just 7 days – RCT April 2018
- Omega-3 should help Pancreatic Cancer in 5 ways – June 2017
Other supplements of interest
- Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015
- Pancreatic cancer prevention and treatment by alternates – Vitamin D, Vitamin C, Curcumin, etc – July 2018
Note: The current study ignores the importance of Vitamin D Genes to Cancer
Cancers might alter CYP24A1 gene
Vitamin D Receptor and Cancers
89+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updatedItems found: 90
 Download the PDF from VitaminDWiki
Intervention
The relationship between vitamin D status or supplementation and cancer outcomes has been examined in several meta-analyses. To address remaining knowledge gaps, we conducted a systematic overview and critical appraisal of pertinent meta-analyses. For meta-analyses of trials, we assessed their quality using AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews), strength of associations using umbrella review methodology and credibility of evidence using GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria. Meta-analyses of observational studies reported inverse associations of 25-hydroxyvitamin D with risk of cancer incidence and cancer mortality and, particularly for colorectal cancer, fulfilled some of Bradford-HilFs causation criteria. In meta-analyses of trials, vitamin D supplementation did not affect cancer incidence. However, we found credible evidence that vitamin D supplementation reduced total cancer mortality risk, with 5 out of 6 meta-analyses reporting a relative risk (RR) reduction of up to 16%: RR=0.84 (95% confidence interval: 0.74-0.95). The strength of the association, however, was classified as weak. This was true among meta-analyses of high, moderate and lower quality (AMSTAR-2-rated). Trials did not include large numbers of vitamin D-deficient participants, many tested relatively low doses and lacked sufficiently powered data on site- specific cancers. In conclusion, meta-analyses show that, while observational evidence indicates that low vitamin D status is associated with a higher risk of cancer outcomes, randomized trials demonstrate that vitamin D supplementation reduces total cancer mortality but not cancer incidence. However, trials with larger proportions of vitamin D-insufficient participants and longer durations of follow-up, plus adequately powered data on site-specific common cancers, would provide further insight into the evidence base
Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 20208020 visitors, last modified 06 Oct, 2020, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 14397 Meta intervention.jpg admin 06 Oct, 2020 139.87 Kb 429 14396 Meta-4.jpg admin 06 Oct, 2020 148.98 Kb 425 14395 Meta-3.jpg admin 06 Oct, 2020 166.27 Kb 391 14394 Meta-2.jpg admin 06 Oct, 2020 177.33 Kb 416 14392 Cancer metanalysis.pdf admin 06 Oct, 2020 399.58 Kb 336 - see also:
- Breast Cancer and VDR
- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer